Browsing by Subject "Central nervous system"

Now showing items 1-5 of 5

    • Intranasal administration of gold nanoparticles designed to target the central nervous system: Fabrication ... 
      Gallardo Toledo, Eduardo; Tapia Arellano, Andreas; Celis, Freddy; Sinai, Tomer; Campos, Marcelo; Kogan, Marcelo J.; Sintov, Amnon C. (Elsevier, 2020)
      The presence of the blood-brain barrier (BBB) limit gold nanoparticles (GNP) accumulation in central nervous system (CNS) after intravenous (IV) administration. The intranasal (IN) route has been suggested as a good strategy ...
    • Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion ... 
      Hernández Cáceres, María Paz; Cereceda, Karina; Hernández, Sergio; Li, Ying; Narro, Carla; Rivera, Patricia; Silva, Patricio; Ávalos, Yenniffer; Jara, Claudia; Burgos, Paulina; Toledo Valenzuela, Lilian; Lagos, Pablo; Cifuentes Araneda, Flavia; Pérez Leighton, Claudio; Bertocchi, Cristina; Clegg, Deborah J.; Criollo Céspedes, Alfredo; Tapia Rojas, Cheril; Burgos, Patricia V.; Morselli, Eugenia (Taylor & Francis, 2020)
      High-fat diet (HFD)-induced obesity is associated with increased cancer risk. Long-term feeding with HFD increases the concentration of the saturated fatty acid palmitic acid (PA) in the hypothalamus. We previously showed ...
    • Peptides and proteins used to enhance gold nanoparticle delivery to the brain: preclinical approaches 
      Velasco Aguirre, Carolina; Morales, Francisco; Gallardo Toledo, Eduardo; Guerrero, Simón; Giralt, Ernest; Araya, Eyleen; Kogan Bocian, Marcelo (Dove Medical Press, 2015)
      An exciting and emerging field in nanomedicine involves the use of gold nanoparticles (AuNPs) in the preclinical development of new strategies for the treatment and diagnosis of brain-related diseases such as neurodegeneration ...
    • Segmental demyelination induced by cerebrospinal fluid of progressive spastic paraparesis: Correlation with ... 
      Schmidt, Jimena; Nien, Jyh Kae; Scherson, Alicia; Campos, Eliseo O.; Cartier Rovirosa, Luis; Alvarez, Jaime (Elsevier Ireland Ltd, 1996)
      Progressive spastic paraparesis (PSP) is a demyelinating disease of the central nervous system. We studied the ability of the cerebrospinal fluid (CSF) of patients to induce alterations in rat peroneal nerves, and to modify ...
    • The influence of size and chemical composition of silver and gold nanoparticles on in vivo toxicity with ... 
      Báez, Daniela F.; Gallardo Toledo, Eduardo Ignacio; Oyarzun, María Paz; Araya, Eyleen; Kogan, Marcelo Javier (Dovepress, 2021)
      The physicochemical and optical properties of silver nanoparticles (SNPs) and gold nanoparticles (GNPs) have allowed them to be employed for various biomedical applications, including delivery, therapy, imaging, and as ...