Browsing by Subject "Chagas disease"

Now showing items 1-7 of 7

    • Effect of ruthenium complexation on trypanocidal activity of 5-nitrofuryl containing thiosemicarbazones 
      Pagano, Mariana; Demoro, Bruno; Toloza, Jeannette; Boiani, Lucía; González, Mercedes; Cerecetto, Hugo; Olea Azar, Claudio; Norambuena, Ester; Gambino, Dinorah; Otero, Lucía (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2009-12)
      In the search of new therapeutic tools for the treatment of American Trypanosomiasis, the largest parasitic disease burden in the American continent, three series of novel ruthenium complexes of the formula [RuCl2(HL)(2)], ...
    • Facing Chagas' Disease: Trypanocidal Properties of New Coumarin-chalcone Scaffolds 
      Vázquez Rodríguez, Saleta; Guinez, Roberto; Matos, María; Olea Azar, Claudio; Maya Arango, Juan; Uriarte, Eugenio; Santana, Lourdes (Bentham Science, 2016)
      With the aim of finding new chemical entities based on coumarin and chalcone scaffolds, new hybrid compounds 2-5 were designed and synthesized. The trypanocidal activity of these compounds was tested against the epimastigote, ...
    • Ferrocenyl and cyrhetrenyl azines containing a 5-nitroheterocyclic moiety: Synthesis, structural characterization, ... 
      Gómez, Johana; Klahn, A. Hugo; Fuentealba, Mauricio; Sierra, Diego; Olea Azar, Claudio; Maya Arango, Juan; Medina, Manuela E. (Elsevier, 2017)
      The synthesis of unsymmetrical ferrocenyl and cyrhetrenyl azines [(h5-C5H4)-CR¼N-N¼CH-2-C4H2X-5-NO2]M (M¼Re(CO)3, Fe(h5-C5H5); R¼H, CH3,X¼O, S) has led to the development of new derivativesof 5-nitroheterocycles as potential ...
    • Platinum-based complexes of bioactive 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-Trypanosoma ... 
      Vieites, Marisol; Otero, Lucía; Santos, Diego; Olea Azar, Claudio; Norambuena, Ester; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Kemmerling Weis, Ulrike; Morello Casté, Antonio; Maya Arango, Juan; Gambino, Dinorah (2009)
      Eight new platinum(II) complexes with 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-trypanosomal activity were synthesized, characterized and in vitro evaluated. Most of the complexes showed IC50 values in the ...
    • Rhenium(I) tricarbonyl compounds of bioactive thiosemicarbazones: Synthesis, characterization and activity ... 
      Rodríguez Arce, Esteban; Machado, Ignacio; Rodríguez, Belén; Lapier, Michel; Zúñiga, María Carolina; Maya Arango, Juan; Olea Azar, Claudio; Otero, Lucía; Gambino, Dinorah (Elsevier Inc., 2017)
      © 2017 Elsevier Inc. American Trypanosomiasis is a chronic infection discovered and described in 1909 by the Brazilian scientist Carlos Chagas. It is caused by the protozoan parasite Trypanosoma cruzi. Although it affects ...
    • Synthesis and Biological in vitro and in vivo Evaluation of 2-(5-Nitroindazol-1-yl)ethylamines and Related ... 
      Martín-Escolano, Rubén; Aguilera-Venegas, Benjamín; Marín, Clotilde; Martín-Montes, Álvaro; Martín-Escolano, Javier; Medina-Carmona, Encarnación; Arán, Vicente J.; Sánchez-Moreno, Manuel (John Wiley and Sons Ltd, 2018)
      © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Chagas disease, a neglected tropical disease caused by infection with the protozoan parasite Trypanosoma cruzi, is a potentially life-threatening illness that affects 5–8 ...
    • Synthesis and study of the trypanocidal activity of catechol-containing 3-arylcoumarins, inclusion in ... 
      Pozo Martínez, Josué Santiago; Salgado Valdés, Francisco Javier; Liempi Manquel, Ana Isabel; Kemmerling Weis, Ulrike; Mera Adasme, Raúl; Olea Azar, Claudio Alberto; Moncada Basualto, Mauricio Javier; Borges, Fernanda; Uriarte, Eugenio; Matos, María Joao (Elsevier, 2022)
      American trypanosomiasis or Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and is considered a neglected disease, being an important problem for public health. Benznidazole (BZN) is the drug used to ...