Browsing by Subject "CoMSIA"

Now showing items 1-2 of 2

    • Novel N-arylsulfonylindoles targeted as ligands of the 5-HT6 receptor. Insights on the influence of C-5 ... 
      Arrieta Rodríguez, Loreto; Espinoza Rosales, Daniela; Vera, Gonzalo; Cho, Young Hwa; Cabezas, David; Vásquez Velásquez, David Reinaldo; Mella Raipán, Jaime; Lagos, Carlos F.; Recabarren Gajardo, Gonzalo (MDPI, 2021)
      A new series of twenty-two C-5 substituted N-arylsulfonylindoles was prepared with the aim of exploring the influence of C-5 substitution on 5-HT6 receptor affinity. Eleven compounds showed moderate to high affinity at the ...
    • Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists ... 
      Lorca, Marcos; Morales Verdejo, César; Vásquez Velásquez, David; Andrades Lagos, Juan Andrés; Campanini Salinas, Javier; Soto Delgado, Jorge; Recabarren Gajardo, Gonzalo; Mella, Jaime (MDPI, 2018)
      The wide tissue distribution of the adrenergic 3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there ...