Browsing by Subject "Diabetes"

Now showing items 1-4 of 4

    • Advanced glycation and ROS: A link between diabetes and heart failure 
      Rojas, Armando; Mercadal, Enrique; Figueroa, Hector; Morales, Miguel A. (2008)
      Despite many advances achieved to date, heart failure (HF) remains a leading cause of morbidity and mortality. There is a widely-accepted consensus that HF and diabetes are strongly linked by at least 3 mechanisms: associated ...
    • Novel insights into the pathogenesis of diabetic cardiomyopathy and pharmacological strategies 
      Muñoz Córdova, Felipe Andrés; Hernández Fuentes, Carolina; López Crisosto, Camila; Troncoso, Mayarling; Calle Chalco, Ximena Elena; Guerrero Moncayo, Alejandra; Gabrielli, Luigi; Chiong Lay, Mario; Castro, Pablo F.; Lavandero González, Sergio (Frontiers Media, 2021)
      Diabetic cardiomyopathy (DCM) is a severe complication of diabetes developed mainly in poorly controlled patients. In DCM, several clinical manifestations as well as cellular and molecular mechanisms contribute to its ...
    • Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2 
      Ocaranza, María Paz; Valderas, Patricio; Moya, Jackeline; Gabrielli, Luigi; Godoy, Iván; Córdava, Samuel; Mac Nab, Paul; García Nannig, Lorena; Farías, Luis; Jalil, Jorge E. (BMC, 2020)
      BackgroundThe intracellular ROCK signaling pathway is an important modulator of blood pressure and of cardiovascular and renal remodeling when Rho-kinase activity is increased. Besides, in preclinical models of diabetes, ...
    • Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists ... 
      Lorca, Marcos; Morales Verdejo, César; Vásquez Velásquez, David; Andrades Lagos, Juan Andrés; Campanini Salinas, Javier; Soto Delgado, Jorge; Recabarren Gajardo, Gonzalo; Mella, Jaime (MDPI, 2018)
      The wide tissue distribution of the adrenergic 3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there ...