Browsing by Subject "High-fat diet"

Now showing items 1-2 of 2

    • Central ceramide signaling mediates obesity-induced precocious puberty 
      Heras, Violeta; Castellano, Juan Manuel; Fernandois, Daniela; Velasco, Inmaculada; Rodríguez Vázquez, Elvira; Roa, Juan; Vázquez, María Jesús; Ruiz Pino, Francisco; Rubio, Matías; Pineda, Rafael; Torres, Encarnación; Avendaño, María Soledad; Paredes Vargas, Alfonso; Pinilla, Leonor; Belsham, Denise; Dieguez, Carlos; Gaytan, Francisco; Casals, Nuria; López, Miguel; Tena Sempere, Manuel (Cell, 2020)
      Childhood obesity, especially in girls, is frequently bound to earlier puberty, which is linked to higher disease burden later in life. The mechanisms underlying this association remain elusive. Here we show that brain ...
    • Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion ... 
      Hernández Cáceres, María Paz; Cereceda, Karina; Hernández, Sergio; Li, Ying; Narro, Carla; Rivera, Patricia; Silva, Patricio; Ávalos, Yenniffer; Jara, Claudia; Burgos, Paulina; Toledo Valenzuela, Lilian; Lagos, Pablo; Cifuentes Araneda, Flavia; Pérez Leighton, Claudio; Bertocchi, Cristina; Clegg, Deborah J.; Criollo Céspedes, Alfredo; Tapia Rojas, Cheril; Burgos, Patricia V.; Morselli, Eugenia (Taylor & Francis, 2020)
      High-fat diet (HFD)-induced obesity is associated with increased cancer risk. Long-term feeding with HFD increases the concentration of the saturated fatty acid palmitic acid (PA) in the hypothalamus. We previously showed ...