Browsing by Subject "Hippocampus"

Now showing items 1-6 of 6

    • Antidepressant-relevant behavioral and synaptic molecular effects of long-term fasudil treatment in chronically ... 
      Román Albasini, Luciano; Díaz Véliz, Gabriela; Olave, Felipe Antonio; Aguayo, Felipe Ignacio; García Rojo, Gonzalo; Corrales, Wladimir Antonio; Silva, Juan Pablo; Ávalos, Ana María; Rojas, Paulina S.; Aliaga, Esteban; Fiedler, Jenny Lucy (Elsevier, 2020)
      Several lines of evidence suggest that antidepressant drugs may act by modulating neuroplasticity pathways in key brain areas like the hippocampus. We have reported that chronic treatment with fasudil, a Rho-associated protein ...
    • Chronic restraint stress produces sex-specific behavioral and molecular outcomes in the dorsal and ventral ... 
      Olave Olave, Felipe; Aguayo, Felipe; Román Albasini, Luciano; Corrales Ibañez, Wladimir; Silva, Juan P.; González, Pablo I.; Lagos, Sara; García, María Alexandra; Alarcón Mardones, Matías; Rojas, Paulina S.; Xu, Xiaojiang; Cidlowski, John A.; Aliaga, Esteban; Fiedler Temer, Jenny (Elsevier, 2022)
      Stress-related disorders display differences at multiple levels according to sex. While most studies have been conducted in male rodents, less is known about comparable outcomes in females. In this study, we found that the ...
    • Corticosterone differentially regulates bax, bcl-2 and bcl-x mRNA levels in the rat hippocampus 
      Cárdenas Muñoz, Sergio Patricio; Parra, C.; Bravo, Jaime F.; Morales, P.; Lara Peñaloza, Hernán; Herrera-Marschitz Muller, Mario; Fiedler Temer, Jenny (ELSEVIER SCI IRELAND LTD, 2002-10-04)
      It has previously been shown that adrenalectomy (ADX) produces apoptosis in the granule cell of the dentate gyrus (DG), and that this effect is prevented by corticosterone replacement. Thus, we have investigated how this ...
    • Deletion of hippocampal glucocorticoid receptors unveils sex-biased microRNA expression and neuronal ... 
      Tejos Bravo, Macarena Verónica Monserrat; Oakley, Robert H.; Whirledge, Shannon D.; Corrales Ibáñez, Wladimir Antonio; Silva, Juan Pablo; García Rojo, Gonzalo Javier; Toledo, Jorge; Sánchez, Wendy; Román Albasini, Luciano Paolo; Aliaga, Esteban; Aguayo Abarca, Felipe Ignacio; Olave Olave, Felipe Antonio; Maracaja Coutinho, Vinicius; Cidlowski b, John A.; Fiedler Temer, Jenny Lucy (Elsevier, 2021)
      Sex differences in the brain have prompted many researchers to investigate the underlying molecular actors, such as the glucocorticoid receptor (GR). This nuclear receptor controls gene expression, including microRNAs ...
    • Hippocampal Memory Recovery After Acute Stress: A Behavioral, Morphological and Molecular Study 
      Aguayo, Felipe Ignacio; Tejos Bravo, Macarena; Díaz Véliz, Gabriela; Pacheco Zapata, Aníbal; García Rojo, Gonzalo; Corrales, Wladimir; Olave, Felipe Antonio; Aliaga, Esteban; Ulloa, José L.; Avalos, Ana M.; Román Albasini, Luciano; Rojas, Paulina S.; Fiedler Temer, Jenny (Frontiers Media S.A., 2018)
      © 2018 Aguayo, Tejos-Bravo, Díaz-Véliz, Pacheco, García-Rojo, Corrales, Olave, Aliaga, Ulloa, Avalos, Román-Albasini, Rojas and Fiedler. Several studies have shown that a single exposure to stress may improve or impair ...
    • Matrix metalloproteinase 9 displays a particular time response to acute stress: variation in its levels and ... 
      Aguayo, Felipe I.; Pacheco Zapata, Aníbal; García Rojo, Gonzalo; Pizarro Bauerle, Javier; Doberti Martínez, Ana Valentina; Tejos Bravo, Macarena; García-Pérez, María A.; Rojas, Paulina S.; Fiedler Temer, Jenny (ACS Publications, 2018-05)
      A single stress exposure facilitates memory formation through neuroplastic processes that reshape excitatory synapses in the hippocampus, probably requiring changes in extracellular matrix components. We tested the hypothesis ...