Browsing by Subject "Hypertension"

Now showing items 1-11 of 11

    • Angiotensin-(1-9) reduces cardiovascular and renal inflammation in experimental renin-independent hypertension 
      González, Leticia; Novoa, Ulises; Moya, Jackeline; Gabrielli, Luigi; Jalil Milad, Jorge; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio; Ocaranza, María Paz (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Hypertension-induced cardiovascular and renal damage can be mediated by activation of the renin-angiotensin-aldosterone system. There are different factors beyond renin-angiotensin-aldosterone system ...
    • Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin ... 
      Ocaranza, Maria Paz; Moya, Jackeline; Barrientos, Victor; Alzamora, Rodrigo; Hevia, Daniel; Morales, Cristobal; Pinto, Melissa; Escudero, Nicolás; García Nannig, Lorena; Novoa, Ulises; Ayala, Pedro; Díaz Araya, Guillermo; Godoy, Ivan; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (Lippincott Williams and Wilkins, 2014)
      BACKGROUND:: Little is known about the biological effects of angiotensin-(1-9), but available evidence shows that angiotensin-(1-9) has beneficial effects in preventing/ameliorating cardiovascular remodeling. OBJECTIVE:: ...
    • Association of the intronic polymorphism rs891512 (G24943A) of the endothelial nitric oxide synthase gene ... 
      Seelenfreund, D.; Lobos, S. R.; Quesada, A.; Saavedra, J. M.; Wolff, C.; López-Stewart, G.; Araya, A. V.; Durruty, P. (2012)
      We investigated two single nucleotide polymorphisms of the NOS3 gene in type 2 diabetic patients (n= 93) and healthy non-diabetic controls (n= 76) and their relationship with smoking habits, body mass index, hypertension ...
    • Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension 
      Martínez Aguayo, Alejandro; Campino, Carmen; Baudrand, René; Carvajal, Cristian; Garcia, Hernán; Aglony, Marlene; Bancalari, Rodrigo; García Nannig, Lorena; Loureiro, Carolina; Vecchiola, Andrea; Tapia Castillo, Alejandra; Valdivia, Carolina; Sanhueza, Sebastián; Fuentes, Cristóbal; Lagos, Carlos F.; Solari, Sandra; Allende, Fidel; Kalergis, Alexis; Fardella, Carlos E. (Lippincott Williams & Wilkins, 2016)
      Objective: To identify novel biomarkers associated with pediatric primary hypertension. Methods: We recruited 350 participants (4-16 years). Anthropometric parameters and aldosterone, plasma renin activity, cortisol, ...
    • Manipulation of ACE2 expression in COVID-19 
      Chaudhry, Farhan; Lavandero González, Sergio; Xie, Xiang; Sabharwal, Basera; Zheng, Ying-Ying; Correa, Ashish; Narula, Jagat; Levy, Phillip (BMJ, 2020)
      SARS-CoV-2 is the virus responsible for the ongoing COVID-19 outbreak. The virus uses ACE2 receptor for viral entry. ACE2 is part of the counter-regulatory renin-angiotensin-aldosterone system and is also expressed in the ...
    • Mitochondria, myocardial remodeling, and cardiovascular disease 
      Verdejo, Hugo; Campo, Andrea del; Troncoso, Rodrigo; Gutiérrez, Tomás; Toro, Barbra; Quiroga, Clara; Pedrozo Cibils, Zully; Muñoz, Juan; García Nannig, Lorena; Castro, Pablo; Lavandero González, Sergio (2012)
      The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
    • Mitochondrial fission and autophagy in the normal and diseased heart 
      Iglewski, Myriam; Hill, Joseph A.; Lavandero González, Sergio; Rothermel, Beverly A. (2010)
      Sustained hypertension promotes structural, functional and metabolic remodeling of cardiomyocyte mitochondria. As long-lived, postmitotic cells, cardiomyocytes turn over mitochondria continuously to compensate for changes ...
    • Novel Nanostructured Polymeric Carriers to Enable Drug Delivery for Cardiovascular Diseases 
      Morales Montecinos, Javier; Sepúlveda Rivas, Sabrina; Oyarzún Ampuero, Felipe; Lavandero González, Sergio; Kogan Bocian, Marcelo (Bentham, 2015)
      Applications of polymeric nanotechnologies for enabling therapies for cardiovascular diseases have shown recent success. Both intravenous and oral administration have been investigated and achieved different degrees of ...
    • Selective increase in cardiac IGF-1 in a rat model of ventricular hypertrophy 
      Ebensperger González, Roberto; Acevedo, Erika; Meléndez, Jaime; Corbalán, Ramón; Acevedo, Mónica; Sapag Hagar, Mario; Jalil Milad, Jorge; Lavandero González, Sergio (Academic Press Inc., 1998)
      There is evidence that insulin-like growth factor-1 (IGF-1) plays a role in the development of left ventricular hypertrophy, but it is uncertain whether cardiac IGP-1 changes before or after hypertension is established, ...
    • Sodium intake is associated with endothelial damage biomarkers and metabolic dysregulation 
      Campino, Carmen; Baudrand, Rene; Valdivia, Carolina; Carvajal, Cristian; Vecchiola, Andrea; Tapia Castillo, Alejandra; Martínez Aguayo, Alejandro; Garcia, Hernán; García Nannig, Lorena; Allende, Fidel; Solari, Sandra; Fuentes, Cristóbal; Lagos, Carlos; Rojas, Maria; Muñoz, Doris; Fardella, Carlos E. (Oxford University Press, 2018)
      BACKGROUND : Mounting evidence has associated high sodium (HS) intake with hypertension, cardiovascular disease, and stroke. We investigated whether HS intake modulates the parameters of endothelial damage, inflammation, ...
    • Vaccines against components of the renin-angiotensin system 
      Garay Gutiérrez, Noé Francisco; Hernández Fuentes, Carolina; García Rivas, Gerardo; Lavandero González, Sergio; Guerrero Beltrán, Carlos Enrique (Springer, 2020)
      Even though effective drugs for treating hypertension are available, a great percentage of patients have inadequate control of their blood pressure. Unwanted side effects and inappropriate oral drug adherence are important ...