Browsing by Subject "Mitochondria"

Now showing items 1-13 of 13

    • Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes 
      Gutiérrez, Tomás; Parra, Valentina; Troncoso, Rodrigo; Pennanen, Christian; Contreras Ferrat, Ariel Eduardo; Vásquez Trincado, César Alonso; Morales, Pablo E.; López Crisosto, Camila; Sotomayor Flores, Cristian Alejandro; Chiong Lay, Mario; Rothermel, Beverly A.; Lavandero González, Sergio (BioMed Central Ltd., 2014)
      © 2014 Gutierrez et al.; licensee BioMed Central Ltd. Background: Cardiac hypertrophy is characterized by alterations in both cardiac bioenergetics and insulin sensitivity. Insulin promotes glucose uptake by cardiomyocytes ...
    • Differential effects of oleic and palmitic acids on lipid droplet-mitochondria interaction in the hepatic ... 
      Eynaudi Cáceres, Andrea Patricia; Díaz Castro, Francisco; Bórquez, Juan Carlos; Bravo Sagua, Roberto Francisco; Parra Ortiz, Valentina María; Troncoso Cotal, Rodrigo Hernán (Frontiers Media, 2021)
      Fatty acid overload, either of the saturated palmitic acid (PA) or the unsaturated oleic acid (OA), causes triglyceride accumulation into specialized organelles termed lipid droplets (LD). However, only PA overload leads ...
    • Down syndrome critical region 1 gene, Rcan1, helps maintain a more fused Mitochondrial Network 
      Parra Ortíz, María Valentina; Altamirano, Francisco; Hernández Fuentes, Carolina; Tong, Dan; Kyrychenko, Victoriia; Rotter, David; Pedrozo Cibils, Zully; Hill, Joseph A.; Eisner, Verónica; Lavandero González, Sergio; Schneider, Jay W.; Rothermel, Beverly A. (Lippincott Williams & Wilkins, 2018)
      Rationale: The regulator of calcineurin 1 (RCAN1) inhibits CN (calcineurin), a Ca2+-activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is located on chromosome 21 in proximity to the Down ...
    • Editorial: Mitochondrial remodeling and dynamic inter-organellar contacts in cardiovascular physiopathology 
      Santulli, Gaetano; Monaco, Giovanni; Parra Ortiz, Valentina Maria; Morciano, Giampaolo (Frontiers Media, 2021)
    • Epigenetic Reader BRD4 (Bromodomain-Containing Protein 4) Governs Nucleus-Encoded Mitochondrial Transcriptome ... 
      Kim, Soo Young; Zhang, Xin; Schiattarella, Gabriele G.; Altamirano, Francisco; Ramos, Thais; French, Kristin M.; Jiang, Nan; Szweda, Pamela A.; Evers, Bret M.; May, Herman; Luo, Xiang; Li, Hongliang; Szweda, Luke; Maracajá Coutinho, Vinicius; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Lippincott Williams & Wilkins, 2020)
      BACKGROUND: BET (bromodomain and extraterminal) epigenetic reader proteins, in particular BRD4 (bromodomain-containing protein 4), have emerged as potential therapeutic targets in a number of pathological conditions, ...
    • Is mitochondrial dysfunction a common root of noncommunicable chronic diseases? 
      Díaz Vegas, Alexis; Sánchez Aguilera, Pablo; Krycer, James R; Morales, Pablo E.; Monsalves Álvarez, Matías; Cifuentes Koster, Mariana; Rothermel, Beverly A.; Lavandero González, Sergio (Endocrine Society, 2020)
      Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. Here, we discuss ...
    • Mitochondria fine-tune the slow Ca2+ transients induced by electrical stimulation of skeletal myotubes 
      Eisner, Verónica; Parra, Valentina; Lavandero González, Sergio; Hidalgo Tapia, María Cecilia; Jaimovich Pérez, Enrique (Elsevier Ltd, 2010)
      Mitochondria sense cytoplasmic Ca2+ signals in many cell types. In mammalian skeletal myotubes, depolarizing stimuli induce two independent cytoplasmic Ca2+ signals: a fast signal associated with contraction and a slow ...
    • Mitochondria, myocardial remodeling, and cardiovascular disease 
      Verdejo, Hugo; Campo, Andrea del; Troncoso, Rodrigo; Gutiérrez, Tomás; Toro, Barbra; Quiroga, Clara; Pedrozo Cibils, Zully; Muñoz, Juan; García Nannig, Lorena; Castro, Pablo; Lavandero González, Sergio (2012)
      The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
    • New molecular and organelle alterations linked to down syndrome heart disease 
      Venegas Zamora, Leslye Paola; Bravo Acuña, Francisco Javier; Sigcho Garrido, Francisco Javier; Gómez Calderón, Wileidy; Bustamante Salazar, José Brayan; Pedrozo Cibils, Zully; Parra Ortiz, Valentina María (Frontiers Media, 2022)
      Down syndrome (DS) is a genetic disorder caused by a trisomy of the human chromosome 21 (Hsa21). Overexpression of Hsa21 genes that encode proteins and non-coding RNAs (ncRNAs) can disrupt several cellular functions and ...
    • Novel insights into the pathogenesis of diabetic cardiomyopathy and pharmacological strategies 
      Muñoz Córdova, Felipe Andrés; Hernández Fuentes, Carolina; López Crisosto, Camila; Troncoso, Mayarling; Calle Chalco, Ximena Elena; Guerrero Moncayo, Alejandra; Gabrielli, Luigi; Chiong Lay, Mario; Castro, Pablo F.; Lavandero González, Sergio (Frontiers Media, 2021)
      Diabetic cardiomyopathy (DCM) is a severe complication of diabetes developed mainly in poorly controlled patients. In DCM, several clinical manifestations as well as cellular and molecular mechanisms contribute to its ...
    • Parkin Gone Wild Unbridled Ubiquitination 
      Cao, Dian J.; Lavandero González, Sergio; Hill, Joseph A. (Lippicott Williams & Wilkins, 2015)
    • Parkin gone wild: Unbridled ubiquitination 
      Cao, Dian J.; Lavandero González, Sergio; Hill, Joseph A. (Lippincott Williams and Wilkins, 2015)
    • The aging of ER-mitochondria communication: a journey from undifferentiated to aged cells 
      Morgado Cáceres, Pablo Andrés; Liabeuf Altamirano, Gianella Alejandra; Calle Chalco, Ximena Elena; Briones Suárez, Lautaro Rigoberto Nabi; Riquelme Meléndez, Jaime Andrés; Bravo Sagua, Roberto Francisco; Parra Ortiz, Valentina María (Frontiers Media, 2022)
      The complex physiology of eukaryotic cells requires that a variety of subcellular organelles perform unique tasks, even though they form highly dynamic communication networks. In the case of the endoplasmic reticulum (ER) ...