Browsing by Subject "Toxicology"
Now showing items 1-11 of 11
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(1986)The absorption and disposition kinetics of lithium carbonate administered to eight healthy volunteers in two dosage forms were studied. A conventional immediate release tablet and a controlled release preparation, developed ...
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(1984)Adverse drug reactions (ADRs) may be more frequent in patients who present some diseases. By means of an intensive prospective drug surveillance work, 492 patients with heart diseases, hospitalized at the Department of ...
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(1993)Modification of cardiac β-adrenergic receptors (β-AR), resulting from the stimulation of the sympathetic nervous system, is one of the most important factors in the generation of cardiac hypertrophy and heart failure. In ...
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(1997)Food-induced changes on bioavailability of 2 sustained release theophylline matrix tablets, which uses an hydrophilic matrix of Carbopol 974P and lipid matrix of hydrogenated castor oil (Cutina HR) as sustaining agents, ...
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(1990)The effect of ethyl alcohol ingestion on erythromycin kinetics was studied. Nine healthy volunteers, four males and five females, participated in the study. They received, in two separate occasions, 500 mg of erythromycin ...
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(1989)Nifurtimox disposition was evaluated in 7 healthy volunteers. Each subject received an oral dose of 15 mg/kg of nifurtimox and blood sample was obtained 11 h after the drug administration. We used an analytical method ...
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(1982)The pharmacokinetics of amoxicillin was investigated in 4 healthy volunteers and in 16 patients with varying degrees of renal impairment, 4 of whom were on regular hemodialysis. Amoxicillin was administered both in a 1-g ...
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(1986)The diposition of gentamicin was studied in five children with nephrotic syndrome and five control children to observe the effect of nephrotic syndrome on the distribution and elimination of the antibiotic. After a single ...
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(1980)Sex-related variations in the clinical effects of drugs may be observed. In an intensive prospective drug surveillance study of 1920 patients hospitalized at the Department of Medicine of the J.J. Aguirre Hospital in ...