Browsing by Subject "Trypanosoma cruzi"

Now showing items 1-14 of 14

    • Chemical and biological analysis of 4-acyloxy-3-nitrocoumarins as trypanocidal agents 
      Salgado, Francisco; Moncada Basualto, Mauricio Javier; Pozo Martínez, Josué Santiago; Liempi, Ana; Kemmerling Weis, Ulrike; Maya Arango, Juan Diego; Jaque Olmedo, Pablo César; Borges, Fernanda; Uriarte, Eugenio; Matos, María J.; Olea Azar, Claudio Alberto (Elsevier, 2021)
      Chagas disease is the most widespread contagious tropical disease in Latin America, being an important public health problem. Treatments against this disease are still very ineffective, presenting several side effects. ...
    • Effect of the metal ion on the anti T. cruzi activity and mechanism of action of 5-nitrofuryl-containing ... 
      Cipriani, Micaella; Toloza, Jeannette; Bradford, Lara; Putzu, Eugenia; Vieites, Marisol; Curbelo, Estela; Tomaz, Ana; Garat, Beatriz; Guerrero, Juan; Gancheff, Jorge; Maya Arango, Juan; Olea Azar, Claudio; Gambino, Dinorah; Otero, Lucía (Wiley-VCH Verlag, 2014)
      Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major health problem worldwide. In this work, we report the development of palladium and platinum metal complexes with 5-nitrofuryl-containing ...
    • Evaluation of the novel antichagasic activity of [1,2,3]triazolo[1,5-a]pyridine derivatives 
      Lapier, Michel; Zúñiga López, María C.; Aguilera Venegas, Benjamín; Adam, Rosa; Abarca, Belén; Ballesteros, Rafael; López Muñoz, Rodrigo; Maya Arango, Juan; Olea Azar, Claudio (Bentham Science Publishers B.V., 2017)
      © 2017 Bentham Science Publishers. Trypanosoma cruzi is the causative agent of Chagas disease. This parasite is vulnerable to the effects of ROS as its main defense mechanism against exogenous agents trypanothione is also ...
    • Facing Chagas' Disease: Trypanocidal Properties of New Coumarin-chalcone Scaffolds 
      Vázquez Rodríguez, Saleta; Guinez, Roberto; Matos, María; Olea Azar, Claudio; Maya Arango, Juan; Uriarte, Eugenio; Santana, Lourdes (Bentham Science, 2016)
      With the aim of finding new chemical entities based on coumarin and chalcone scaffolds, new hybrid compounds 2-5 were designed and synthesized. The trypanocidal activity of these compounds was tested against the epimastigote, ...
    • Ferrocenyl and cyrhetrenyl azines containing a 5-nitroheterocyclic moiety: Synthesis, structural characterization, ... 
      Gómez, Johana; Klahn, A. Hugo; Fuentealba, Mauricio; Sierra, Diego; Olea Azar, Claudio; Maya Arango, Juan; Medina, Manuela E. (Elsevier, 2017)
      The synthesis of unsymmetrical ferrocenyl and cyrhetrenyl azines [(h5-C5H4)-CR¼N-N¼CH-2-C4H2X-5-NO2]M (M¼Re(CO)3, Fe(h5-C5H5); R¼H, CH3,X¼O, S) has led to the development of new derivativesof 5-nitroheterocycles as potential ...
    • Ibandronate metal complexes: solution behavior and antiparasitic activity 
      Demoro, Bruno; Rostan, Santiago; Moncada, Mauricio; Li, Zhu Hong; Docampo, Roberto; Olea Azar, Claudio; Maya Arango, Juan; Torres, Julia; Gambino, Dinorah; Otero, Lucia (Springer, 2018)
      To face the high costs of developing new drugs, researchers in both industry and academy are looking for ways to repurpose old drugs for new uses. In this sense, bisphosphonates that are clinically used for bone diseases ...
    • Isradipine and lacidipine: Effects in vivo and in vitro on Trypanosoma cruzi epimastigotes 
      Núñez Vergara, Luis; Squella Serrano, Juan; Bollo Dragnic, Soledad; Marín Catalán, Rigoberto; Pino, L.; Díaz Araya, Guillermo; Letelier Muñoz, María Eugenia (PERGAMON-ELSEVIER SCIENCE LTD, 1998-01)
      1. Isradipine and lacidipine, two new drugs that are members of the nitro-aryl-1,4-dihydropyridine family, produced inhibition of both growth cultures and oxygen consumption on epimastigotes of Trypanosoma cruzi Tulahuen ...
    • Nitro aryl 1,4-dihydropyridine derivatives: Effects of Trypanosoma cruzi 
      Núñez Vergara, Luis; Squella Serrano, Juan; Bollo Dragnic, Soledad; Morello Casté, Antonio; Repetto Scaramelli, Yolanda; Aldunate, Jorge; Letelier, María E. (1997)
      A series of nitro aryl 1,4-dihydropyridine derivatives produced inhibition of both cell growth and oxygen consumption on Tulahuen and LQ strains, and clone Dm 28c of epimastigotes of Trypanosoma cruzi. Nicardipine was found ...
    • Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic ... 
      Fernández, Mariana; Rodríguez Arce, Esteban; Sarniguet, Cynthia; Morais, Tânia S.; Tomaz, Ana Isabel; Olea Azar, Claudio; Figueroa, Roberto; Maya Arango, Juan; Medeiros, Andrea; Comini, Marcelo; Garcia, M. Helena; Otero, Lucía; Gambino, Dinorah (Elsevier, 2015)
      Searching for new prospective antitrypanosomal agents, three novel Ru(II)-cyclopentadienyl compounds, [Ru(eta(5)-C5H5)(PPh3)L], with HL = bioactive 5-nitrofuryl containing thiosemicarbazones were synthesized and characterized ...
    • Platinum-based complexes of bioactive 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-Trypanosoma ... 
      Vieites, Marisol; Otero, Lucía; Santos, Diego; Olea Azar, Claudio; Norambuena, Ester; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Kemmerling Weis, Ulrike; Morello Casté, Antonio; Maya Arango, Juan; Gambino, Dinorah (2009)
      Eight new platinum(II) complexes with 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-trypanosomal activity were synthesized, characterized and in vitro evaluated. Most of the complexes showed IC50 values in the ...
    • Rhenium(I) tricarbonyl compounds of bioactive thiosemicarbazones: Synthesis, characterization and activity ... 
      Rodríguez Arce, Esteban; Machado, Ignacio; Rodríguez, Belén; Lapier, Michel; Zúñiga, María Carolina; Maya Arango, Juan; Olea Azar, Claudio; Otero, Lucía; Gambino, Dinorah (Elsevier Inc., 2017)
      © 2017 Elsevier Inc. American Trypanosomiasis is a chronic infection discovered and described in 1909 by the Brazilian scientist Carlos Chagas. It is caused by the protozoan parasite Trypanosoma cruzi. Although it affects ...
    • Synthesis and Biological in vitro and in vivo Evaluation of 2-(5-Nitroindazol-1-yl)ethylamines and Related ... 
      Martín-Escolano, Rubén; Aguilera-Venegas, Benjamín; Marín, Clotilde; Martín-Montes, Álvaro; Martín-Escolano, Javier; Medina-Carmona, Encarnación; Arán, Vicente J.; Sánchez-Moreno, Manuel (John Wiley and Sons Ltd, 2018)
      © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Chagas disease, a neglected tropical disease caused by infection with the protozoan parasite Trypanosoma cruzi, is a potentially life-threatening illness that affects 5–8 ...
    • Synthesis and study of the trypanocidal activity of catechol-containing 3-arylcoumarins, inclusion in ... 
      Pozo Martínez, Josué Santiago; Salgado Valdés, Francisco Javier; Liempi Manquel, Ana Isabel; Kemmerling Weis, Ulrike; Mera Adasme, Raúl; Olea Azar, Claudio Alberto; Moncada Basualto, Mauricio Javier; Borges, Fernanda; Uriarte, Eugenio; Matos, María Joao (Elsevier, 2022)
      American trypanosomiasis or Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and is considered a neglected disease, being an important problem for public health. Benznidazole (BZN) is the drug used to ...
    • Water-Soluble Ruthenium Complexes Bearing Activity Against Protozoan Parasites 
      Sarniguet, Cynthia; Toloza, Jeannette; Cipriani, Micaella; Lapier, Michel; Vieites, Marisol; Toledano Magaña, Yanis; García Ramos, Juan Carlos; Ruiz Azuara, Lena; Moreno, Virtudes; Maya Arango, Juan; Olea Azar, Claudio; Gambino, Dinorah; Otero, Lucía (Springer, 2014)
      Parasitic illnesses are major causes of human disease and misery worldwide. Among them, both amebiasis and Chagas disease, caused by the protozoan parasites, Entamoeba histolytica and Trypanosoma cruzi, are responsible ...