Now showing items 601-620 of 2801

    • Hassan, Natalia; Oyarzún Ampuero, Felipe; Muñoz Lara, Pablo; Guerrero, Simón; Cabuil, Valérie; Abou-Hassan, Ali; Kogan Bocian, Marcelo (Bentham Science Publishers B.V., 2014)
      In this article we review the flow chemistry methodologies for the controlled synthesis of different kind of nano and microparticles for biomedical applications. Injection mechanism has emerged as new alternative for the ...
    • Jara, José A.; Castro Castillo, Vicente; Saavedra-Olavarría, Jorge; Peredo, Liliana; Pavanni, Mario; Jaña, Fabián; Letelier, María Eugenia; Parra, Eduardo; Becker, María Inés; Morello Casté, Antonio; Kemmerling Weis, Ulrike; Maya Arango, Juan; Ferreira, Jorge (American Chemical Society, 2014)
      Tumor cells principally exhibit increased mitochondrial transmembrane potential (Δψm) and altered metabolic pathways. The therapeutic targeting and delivery of anticancer drugs to the mitochondria might improve treatment ...
    • Morales, Pablo E.; Torres, Gloria; Sotomayor Flores, Cristian Alejandro; Peña Oyarzún, Daniel; Rivera Mejías, Pablo; Paredes, Felipe; Chiong Lay, Mario (Academic Press Inc., 2014)
      Incretin GLP-1 has important metabolic effects on several tissues, mainly through the regulation of glucose uptake and usage. One mechanism for increasing cell metabolism is modulating endoplasmic reticulum (ER)-mitochondria ...
    • Nassif, Melissa; Valenzuela, Vicente; Rojas Rivera, Diego; Vidal, René; Matus, Soledad; Castillo, Karen; Fuentealba, Yerko; Kroemer, Guido; Levine, Beth; Hetz Flores, Claudio (Taylor and Francis Inc., 2014)
      Pharmacological activation of autophagy is becoming an attractive strategy to induce the selective degradation of aggregate-prone proteins. Recent evidence also suggests that autophagy impairment may underlie the pathogenesis ...
    • Pardo Jiménez, Viviana Gladys; Barrientos, C.; Pérez Cruz, Karina Angélica; Navarrete Encina, Patricio; Olea Azar, Claudio; Núñez Vergara, Luis; Squella Serrano, Juan (2014)
      In this paper, a series of six dihydropyridine-fused coumarins were synthesized and electrochemically characterized in dimethylformamide (DMF). Dihydropyridine ring oxidation on glassy carbon electrode (GCE) for condensed ...
    • Acuña Rougier, C.; Jullian,; Olea Azar, Claudio (2012)
      Complexes formed by (±)-4′-hydroxyflavanone (OHFL) and the cyclodextrins β-cyclodextrin and (2-hydroxypropyl)-β-CD were obtained using the racemic mixture of the OHFL. These complexes were able to be studied due to their ...
    • Ocaranza, Maria Paz; Moya, Jackeline; Barrientos, Victor; Alzamora, Rodrigo; Hevia, Daniel; Morales, Cristobal; Pinto, Melissa; Escudero, Nicolás; García Nannig, Lorena; Novoa, Ulises; Ayala, Pedro; Díaz Araya, Guillermo; Godoy, Ivan; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (Lippincott Williams and Wilkins, 2014)
      BACKGROUND:: Little is known about the biological effects of angiotensin-(1-9), but available evidence shows that angiotensin-(1-9) has beneficial effects in preventing/ameliorating cardiovascular remodeling. OBJECTIVE:: ...
    • Parada, Mirtha; Valenzuela Barra, Gabriela; Delporte, Carla; Lara Peñaloza, Hernán (Universidad de Santiago de Chile, 2014)
      The estrous cycle disruptor effect of an ethanolic extract (EMATst) from Buddleja globosa leaves and standardized in its main component (verbascoside) was determined in rats after the subcutaneous administration of EMATst. ...
    • Riveros, Ana; Dadlani, Komal; Salas, Edison; Caballero, Leonardo; Melo, Francisco; Kogan Bocian, Marcelo (American Scientific Publishers, 2013)
      There has been an increase in the research towards the use of nanoparticles as a promising tool for nanomedicine, from imagenology, drug and gene delivery, to phototherapy. Little is known regarding the interaction between ...
    • Mena, Juan F.; Neira Carrillo, Andrónico; Yazdani-Pedram Zobeiri, Mehrdad; Kogan Bocian, Marcelo (American Scientific Publishers, 2013)
      With the purpose of obtaining stable and non-toxic nanocomposites with potential biomedical applications we coated gold nanoparticles (AuNP) with chitosan (CHI) and CHI grafted with poly(Nisopropilacrylamide) (PNIPAAm) and ...
    • Pérez, M. De Los A.Arada; Yazdani-Pedram Zobeiri, Mehrdad (2013)
      ABSTRACT Chloride selective polymeric liquid membrane electrode has been developed by using Bis-(2-ethylhexyl) Sebacate (DOS) as plasticizer and 2-[5-(4-nitrophenyl) furyl]-4,5-diphenyl imidazole (FFDFIN) as ionophore. ...
    • Folch Cano, Christian; Guerrero, Juan; Speisky Cosoy, Hernán; Jullian Matthaei, Carolina; Olea Azar, Claudio (2014)
      The present study is focused on the characterization of the interaction between (-)-epigallocatechingallate (EGCG) and cyclodextrins like β-cyclodextrin (βCD), heptakis(2,6 di-O-methyl)-β-cyclodextrin (DMβCD), and ...
    • Gamboa, J.; Cornejo, L.; Acarapi, J.; Squella Serrano, Juan (Sociedad Chilena de Quimica, 2013)
      As (III) was determined by differential pulse polarography (DPP) in 1 mol L-1 HCl as supporting electrolyte. For quantification, the -0.35 V peak (versus Ag/AgCl) was chosen. The obtained detection and quantification limits ...
    • Pedreschi, Franco; Bunger Timmermann, Andrea; Skurtys, Olivier; Allen, Paula; Rojas, Ximena (2012)
      Potato chips were classified in quality categories according to their color after frying at oil temperatures (120, 140, 160, and 180 ± 1 °C) and undergoing some pre-treatments (control or unblanching, blanching, and blanching ...
    • Cancino, Patricio; Spodine Spiridonova, Evgenia; Paredes García, Verónica; Venegas Yazigi, Diego; Vega, Andrés (2013)
      In the structure of the title compound, {[Cu-2(C10H2O8)-(H2O)(6)]center dot 4H(2)O}(n), the benzene-1,2,4,5-tetracarboxylate ligand, (btec)(4-), is located on a crystallographic inversion centre in a 4-coordination mode. ...
    • Jara Ulloa, Paola Andrea; Salgado Figueroa, Paola; Yañez,; Núñez Vergara, Luis; Squella Serrano, Juan (2012)
      We report the adsorptive voltammetric determination of nifedipine on multiwalled carbon nanotubes (MWCNT)-modified glassy carbon electrode (GCE). Nifedipine was adsorbed on the MWCNT and then reduced using linear sweep and ...
    • Lavandero González, Sergio; Troncoso Cotal, Rodrigo; Rotherme, Beverly; Martinet, Wim; Sadoshima, Junichi; Hill, Joseph (Taylor and Francis Inc., 2013)
      Despite recent scientific and technological advances, cardiovascular disease remains the leading cause of morbidity and mortality worldwide. Autophagy, an evolutionarily ancient response to cellular stress, has been ...
    • Cañete Rosales, Paulina; Álvarez Lueje, Alejandro; Bollo Dragnic, Soledad (2014)
      In this paper, for the first time, an electro-analytical method based on the direct adsorption of double-stranded deoxyribonucleic acid (dsDNA) at glassy carbon electrode modified with ethylendiamine (eda)functionalized ...
    • Atala, E.; Aspée, Alexis; Speisky Cosoy, Hernán; Lissi Gervaso, Eduardo A.; López Alarcón, Camilo (2013)
      A novel ORAC (oxygen radical absorbance capacity) assay to assess antioxidant capacity of phenolic compounds in near-gastric conditions (pH 2.0) is presented. AAPH (2,2'-azo-bis(2-amidinopropane)dihydrochloride) was used ...
    • Garrido Reyes, Tatiana; Mendoza Crisosto, Jorge; Velásquez Vergara, Yaris (2013)
      O objetivo deste estudo foi utilizar a técnica de difusão em filmes finos por gradiente de concentração (DGT) para a avaliação da disponibilidade de cobre em solos com elevados níveis do metal, que foi alterado com ...