Now showing items 1-20 of 21

    • Araya, Magdalena; Núñez, Héctor; Pavez, Leonardo; Arredondo Olguín, Miguel Armando; Méndez, Marco; Cisternas, Felipe; Pizarro Aguirre, Fernando; Sierralta, Walter; Uauy Dagach-Imbarack, Ricardo; González Canales, Mauricio (American Society for Nutrition, 2012)
      Liver cells respond to copper loading upregulating protective mechanisms. However, to date, except for liver content, there are no good indicators that identify individuals with excess liver copper. We hypothesized that ...
    • Arredondo Olguín, Miguel; Weisstaub Nuta, Sergio; Medina, Marcos; Suazo Romo, Miriam; Guzmán, Miguel; Araya, Magdalena (Elsevier, 2014)
      It is not clear how frequent is copper deficiency in humans. Current copper markers are not sensitive enough to detect early copper deficiency and new markers are needed. CCS is a candidate to become a copper ...
    • Luque, Cecilia; Cisternas, Felipe A.; Araya, Magdalena (2006)
      Background: During the twentieth century there was a change in the pattern of diseases in Europe, with an increase in the incidence of allergies and autoimmune disorders, that paralleled a decrease of infectious conditions. ...
    • Araya, Magdalena; Gutiérrez, Ricardo; Arredondo Olguín, Miguel (Springer, 2014)
      The chaperone to Zn–Cu superoxide dismutase (CCS) has been postulated as a candidate copper indicator, changing in a consistent manner in induced and recovered copper deficiency, in experimental cell and animal models. ...
    • Araya, Magdalena; Andrews, Mónica; Pizarro Aguirre, Fernando; Arredondo Olguín, Miguel Armando (Springer, 2012-04)
      Assessment of proteins in blood and other tissues has failed to identify markers of early copper effects on health. Studies in animal models show that chaperone of SOD (CCS) respond to changes of copper status. Evidence ...
    • Araya, Magdalena; Olivares Grohnert, Manuel; Pizarro Aguirre, Fernando; Llanos, Adolfo; Figueroa, Guillermo; Uauy Dagach-Imbarack, Ricardo (US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE, 2004-07)
      We assessed gastrointestinal effects in 1,365 adults exposed to either < 0.01 (controls), 2, 4, or 6 mg copper/L of drinking water for 2 months in a randomized, double-blind community-based study. The risk of symptoms ...
    • Araya, Magdalena; Chen, Bingheng; Klevay, Leslie M.; Strain, J. J.; Johnson, Luann; Robson, Paula; Shi, Wei; Nielsen, Forrest; Zhu, Huigang; Olivares Grohnert, Manuel; Pizarro Aguirre, Fernando; Haber, Lynne T. (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2003-12)
      In a double blind, 3 x 3 factorial (volume x dose) study, 70 adult females (18-60 years of age) at four different international sites (total pooled n = 269) were given 100, 150, or 200 ml of bottled drinking water with ...
    • Rojas Sobarzo, Loreto; Olivares Grohnert, Manuel; Brito, Alex; Suazo Romo, Miriam; Araya, Magdalena; Pizarro Aguirre, Fernando (Springer, 2013)
      Copper (Cu) deficiency has been reported to influence lipid metabolism, but the effects in humans are controversial. To evaluate the effects of 8 mg Cu/day supplementation (as copper sulfate) for 6 months on the lipid ...
    • Muñoz, Carlos; López, Marcelo; Olivares Grohnert, Manuel; Pizarro Aguirre, Fernando; Arredondo Olguín, Miguel Armando; Araya, Magdalena (EUROPEAN CYTOKINE NETWORK, 2005-12)
      Backgound. Copper (Cu) is an essential trace element for many biological processes including maintenance of both innate and acquired branches of immunity. Objective. To measure the effect of copper supplementation on IL-2 ...
    • Araya, Magdalena; Oyarzún, Amaya; Lucero Álvarez, Yalda; Espinosa, Nelly; Pérez Bravo, Francisco (MDPI AG, 2015)
      HLA-linked genes are relevant to celiac disease (CD); the potential genetic differences present worldwide are not fully understood. Previous results suggest that the distribution of HLA-DQ2/DQ7/DQ8 in Chile may differ from ...
    • Araya, Magdalena; Kelleher, Shannon; Arredondo Olguín, Miguel; Sierralta, Walter; Vial, María Teresa; Uauy Dagach-Imbarack, Ricardo; Lonnerdal, Bo (AMER SOC CLINICAL NUTRITION, 2005-05)
      Background: Whether infants regulate copper absorption and the potential effects of excess copper in early life remain poorly defined. Objective: The objective of the study was to assess copper retention, liver copper ...
    • Canales, Paulina; Araya, Magdalena; Alliende G., Francisco; Hunter, Bessie; Alarcón Orellana, Teresa; Chávez S., Eduardo (SOC MEDICA SANTIAGO, 2008-03)
      Background: Ample use of serological markets of high sensitivity and specificity led to relevant changes in the epidemiology of celiac disease. The impact of these changes in our country is poorly known. Aim: To assess the ...
    • Tapia S., Alexis; Araya, Magdalena (2006)
      The frequency of Crohn disease shows a significant increase in the last century. Affected patients show a misbalance between production of free radicals and anti oxidant defenses. Thus, one of the increasingly accepted ...
    • Parada, Alejandra; Araya, Magdalena (SOC MEDICA SANTIAGO, 2010-10)
      The global prevalence of celiac disease is of one person per 250 inhabitants. The disease is induced by gluten, a peptide contained in wheat, rye and barley that during small intestinal digestion generates smaller peptides. ...
    • Araya, Magdalena (2006)
      Anti endomysial and anti transglutaminase (EMA/TTG) antibodies measurements in large population groups, show that celiac disease is significantly more common than previously thought and 0.5-1% of the population suffer ...
    • Olguín, F.; Araya, Magdalena; Hirsch Birn, Sandra; Brunser, O.; Ayala, V.; Rivera, R.; Gotteland, Martín (ELSEVIER, 2005-06)
      Prebiotics increase intestinal levels of health-promoting bacteria implicated in decreasing pathogen colonization, stimulating immune functions and stabilizing gut barrier functions, parameters which are altered in burn ...
    • Olivares, Manuel; Lera Marques, Lydia; Albala Brevis, Cecilia; Pizarro Aguirre, Fernando; Araya, Magdalena (SOC MEDICA SANTIAGO, 2011-03)
      Background: Older subjects have a high risk of developing zinc and copper deficiencies. Aim: To determine the prevalence of copper and zinc deficiencies in adults aged over 60 years, living in Metropolitan Santiago. Subjects ...
    • Navarro, Elizabeth; Araya, Magdalena (Sociedad Médica de Santiago, 2015)
      Remission of gastrointestinal and general symptoms after gluten withdrawal has been described in some non-celiac individuals for nearly 30 years. Only recently, efforts have been made to define this entity, now referred ...
    • Méndez, Marco; Araya, Magdalena; Ordóñez Pizarro, Fernando; Pizarro Aguirre, Fernando; González Canales, Mauricio (US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE, NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, 2004-12)
      Previous studies indicated that sex might influence the response to copper exposure. Cenaloplasmin (Cp) is an indicator of Cu status, but it is not clear whether and how it reflects changes of Cu status among healthy ...
    • Araya, Magdalena; Olivares Grohnert, Manuel; Pizarro Aguirre, Fernando; Méndez, Marco; González Canales, Mauricio; Uauy Dagach-Imbarack, Ricardo (The Journal of Nutrition, 2005-10)
      The health consequences of mild copper excess in humans are unknown. In a previous study, 2 mo of supplementation with up to 6 mg Cu/L in drinking water did not induce detectable changes. Here we assessed a copper ...