Browsing by Author "Ronco Macchiavello, Ana María"

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    • Cardiac Tissue Injury Resistance During Myocardial Infarction at Adulthood by Developmental Exposure to Cadmium 
      Zepeda Iriarte, Ramiro; Castillo, Paula; Sáez, Daniel; Llanos Silva, Miguel; Ronco Macchiavello, Ana María (Springer, 2012)
      It has been suggested that prenatal exposure to cadmium may alter the cardiovascular function during adulthood. Using the left coronary artery ligation model of acute myocardial infarction, we studied the cardiac ...
    • Effect of cadmium on cortisol production and 11 beta-hydroxysteroid dehydrogenase 2 expression by cultured ... 
      Ronco Macchiavello, Ana María; Llaguno, Emanuel; Epuñán, María José; Llanos Silva, Miguel (PERGAMON-ELSEVIER SCIENCE LTD, 2010-09)
      Cadmium is a toxicant with known carcinogenic and endocrine disruptor effects. We have previously reported that prenatal exposure to cadmium may induce low birth weight which is associated to increased foetal exposure ...
    • Folates Induce Colorectal Carcinoma HT29 Cell Line Proliferation Through Notch1 Signaling 
      Rodríguez, Juan M.; Miranda, Dante; Bunout Barnett, Daniel; Ronco Macchiavello, Ana María; Maza Cave, María Pía de la; Hirsch Birn, Sandra (ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2015)
      Folic acid (FA) consumption at high levels has been associated with colon cancer risk. Several mechanisms have been proposed to explain this association. The Notch signal pathway has been implicated in the regulation of ...
    • Folic Acid Supplementation during Pregnancy Induces Sex-Specific Changes in Methylation and Expression of ... 
      Peñailillo, Reyna; Guajardo, Angélica; Llanos Silva, Miguel; Hirsch Birn, Sandra; Ronco Macchiavello, Ana María (Public Library Science, 2015)
      In the placenta, 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) limits fetal glucocorticoid exposure and its inhibition has been associated to low birth weight. Its expression, encoded by the HSD11B2 gene is ...
    • Increased levels of metallothionein in placenta of smokers 
      Ronco Macchiavello, Ana María; Argüello, Graciela; Suazo Romo, Miriam; Llanos Silva, Miguel (ELSEVIER SCI IRELAND LTD, 2005-03-01)
      Experiments were designed to evaluate and compare metallothionein (NIT), zinc and cadmium levels in human placentas of smoking and non-smoking women. Smoking was assessed by self-reported cigarette consumption and urine ...
    • Lack of effect of diet-induced hypomethylation on endothelium-dependent relaxation in rats 
      Hirsch Birn, Sandra; Ronco Macchiavello, Ana María; Pinardi Testa, Gianni; Montequin, María José; Leiva Balich, Laura; Maza Cave, María Pía de la; Llanos Silva, Miguel; Bunout Barnett, Daniel (CHURCHILL LIVINGSTONE, 2008-12)
      Background: Endothelial dysfunction is a key process in atherosclerosis. Hypomethylation is one of the postulated mechanisms involved in atherogenesis and is mainly secondary to a decrease in essential factors such as, ...
    • Methylation status in healthy subjects with normal and high serum folate concentration 
      Hirsch Birn, Sandra; Ronco Macchiavello, Ana María; Guerrero Bosagna, Carlos; Maza Cave, María Pía de la; Leiva Balich, Laura; Barrera Acevedo, María; Llanos Silva, Miguel; Alliende Rodríguez, María Angélica; Silva, Francisca; Bunout Barnett, Daniel (ELSEVIER, 2008-12)
      Objective: We assessed the impact of high serum folate concentration oil erythrocyte S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) concentrations, SAM/SAH ratio, CpG methylation levels across the promoter region ...
    • Natural killer cell cytotoxicity is not regulated by folic acid in vitro 
      Hirsch Birn, Sandra; Miranda, Dante; Muñoz, Estefanía; Montoya, Margarita; Ronco Macchiavello, Ana María; Maza Cave, María Pía de la; Bunout Barnett, Daniel (Elsevier, 2013)
      Objectives: Folate supplementation may be associated with an increased risk of developing several types of cancer and a derangement of immune function.Among the latter, Natural killer (NK) cells are involved in ...
    • Sistema endocanabinoide y desarrollo de esteatosis hepática 
      Valenzuela, Carina; Castillo, Valeska; Ronco Macchiavello, Ana María; Aguirre, Carolina; Hirsch Birn, Sandra; Llanos Silva, Miguel (2014)
      The endocannabinoid system (SEC) is an important modulator of several metabolic functions. This system is composed by cannabinoid receptors type 1 and 2 (RCB1 and RCB2), their endogenous ligands, known as endocannabinoids, and ...
    • Smoking specifically induces metallothionein-2 isoform in human placenta at term 
      Ronco Macchiavello, Ana María; Garrido, Fernando; Llanos Silva, Miguel (ELSEVIER, 2006-06-01)
      Recently, we reported the presence of higher levels of metallothionein (MT) in placentas of smokers compared to non-smokers. In the present study, we designed experiments to separate and evaluate two isoforms of NIT (MT-1 ...