| Author | dc.contributor.author | Acuña Castillo, Claudio | |
| Author | dc.contributor.author | Scorza, Cecilia | es_CL |
| Author | dc.contributor.author | Reyes Parada, Miguel | es_CL |
| Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
| Author | dc.contributor.author | Huidobro Toro, Juan Pablo | es_CL |
| Admission date | dc.date.accessioned | 2012-05-18T15:04:15Z | |
| Available date | dc.date.available | 2012-05-18T15:04:15Z | |
| Publication date | dc.date.issued | 2000-06-06 | |
| Cita de ítem | dc.identifier.citation | Life Sciences 67:3241–3247, 2000 . | es_CL |
| Identifier | dc.identifier.issn | 3241–3247 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119402 | |
| Abstract | dc.description.abstract | To assess the pharmacodynamic profile of ALEPH-2, a phenylisopropylamine derivative with alleged
anxiolytic and hallucinogenic properties, Xenopus laevis oocytes were microinjected with either
of the rat cRNA for the 5-HT2A or the 5-HT2C receptor. Concentration-response curves were obtained
following the exposure of the oocytes to varying concentrations of either ALEPH-2 or 5-hydroxytryptamine
(5-HT) for 10 s. ALEPH-2 is a partial agonist on the 5-HT2A receptor with a similar potency
to 5-HT. In contrast, ALEPH-2 is a full 5-HT2C receptor agonist and is about 15-fold less potent
than 5-HT. Pre-application of 1
mM ritanserin antagonized the responses induced by 5-HT and ALEPH-2
to the same extent; however, the 5-HT2A receptor is more sensitive to ritanserin blockade than the 5-HT2C
receptor. | es_CL |
| Patrocinador | dc.description.sponsorship | Support by DICYT Grant 029901 RP to MRP, FONDAP grant
13980001 and MIFAB (Millenium Institute for Fundamental and Applied Biology, funded
in part by Ministerio de Planificación y Cooperación, Chile) to JPHT and IASBB to BKC is
also acknowledged. | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | Elsevier Science Inc. | es_CL |
| Keywords | dc.subject | ALEPH-2; 5-hydroxytryptamine | es_CL |
| Título | dc.title | ALEPH-2, a suspected anxiolytic and putative hallucinogenic phenylisopropylamine derivative, is a 5-HT2a and 5-HT2c receptor agonist | es_CL |
| Document type | dc.type | Artículo de revista | |
