| Author | dc.contributor.author | Andreu, Inmaculada | |
| Author | dc.contributor.author | Cortes, Diego | es_CL |
| Author | dc.contributor.author | Protais, Philippe | es_CL |
| Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
| Author | dc.contributor.author | Chagraoui, Abdeslam | es_CL |
| Author | dc.contributor.author | Cabedo, Nuria | es_CL |
| Admission date | dc.date.accessioned | 2012-05-18T15:04:32Z | |
| Available date | dc.date.available | 2012-05-18T15:04:32Z | |
| Publication date | dc.date.issued | 1999-11-15 | |
| Cita de ítem | dc.identifier.citation | Bioorganic & Medicinal Chemistry 8: 889-895, 2000. | es_CL |
| Identifier | dc.identifier.issn | 0968-0896 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119404 | |
| Abstract | dc.description.abstract | AbstractÐThe preparation of N-methyl-BTHIQ (4) from N-phenylethyl-phenacetamide (1) by cyclization, reduction and N-alkyl-
ation in acid medium has been achieved in good yield in a `one-pot' procedure. Acylation of imine (2) intermediate a orded the
Z and E stereoselectivity in the enamide formation. 6-Hydroxy-BTHIQ (7) shows selectivity for D2 dopamine receptors, while
its N-methylated homologue (8) displays higher a nities for both D1 and D2 receptor types, with an unexpected increase in D1
dopamine receptor a nity. | es_CL |
| Patrocinador | dc.description.sponsorship | This research was supported by the Spanish DGICYT
under grant SAF 97-0013 and, in part, by the Presi-
dential Chair in Sciences (Chile, BKC). | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | Elsevier Science Ltd. | es_CL |
| Título | dc.title | Preparation of Dopaminergic N-Alkyl-benzyltetrahydro-isoquinolines Using a `One-Pot' Procedure in Acid Medium | es_CL |
| Document type | dc.type | Artículo de revista | |
