| Author | dc.contributor.author | Cabedo, Nuria | |
| Author | dc.contributor.author | Protais, Philippe | es_CL |
| Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
| Author | dc.contributor.author | Cortes, Diego | es_CL |
| Admission date | dc.date.accessioned | 2012-05-18T19:21:59Z | |
| Available date | dc.date.available | 2012-05-18T19:21:59Z | |
| Publication date | dc.date.issued | 1998-01-15 | |
| Cita de ítem | dc.identifier.citation | Journal of Natural Products, Vol. 61, No. 6, 1998. | es_CL |
| Identifier | dc.identifier.issn | 0163-3864 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119408 | |
| Abstract | dc.description.abstract | (R)-(+)-nor-Roefractine (1) was synthesized
by the Bischler-Napieralski route, using asymmetric
reduction of the 1,2-didehydro precursor imine with
sodium (S)-N-CBZ-prolinyloxyborohydride. Compound
1 was able to displace [3H]-raclopride (a D2 dopamine
receptor-selective ligand) from its specific binding sites
in rat striatum with selectivity vs [3H]-SCH23390 (D1
dopamine receptor-selective ligand). | es_CL |
| Patrocinador | dc.description.sponsorship | This research was supported by
the Spanish DGICYT under Grant No. SAF 97-0013,
by an ECOS (France)/CONICYT (Chile) exchange program,
and by the Presidential Chair in Science (Chile,
1996). | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | American Chemical Society and American Society of Pharmacognosy | es_CL |
| Título | dc.title | Synthesis and Dopamine Receptor Selectivity of the Benzyltetrahydroisoquinoline, (R)-(+)-nor-Roefractine | es_CL |
| Document type | dc.type | Artículo de revista | |
