Nitro radical anion formation from nitrofuryl substituted 1,4-dihydropyridine derivatives in mixed and non-aqueous media

Abstract

Three new nitrofuryl substituted 1,4-dihydropyridine derivatives were electrochemically tested in the scope of newly found compounds useful as chemotherapeutic alternative to the Chagas' disease. All the compounds were capable to produce nitro radical anions sufficiently stabilized in the time window of the cyclic voltammetric experiment. In order to quantify the stability of the nitro radical anion we have calculated the decay constant, k(2). Furthermore, from the voltammetric results, some parameters of biological significance as E-7(1) (indicative of in vivo nitro radical anion formation) and K-O2 (thermodynamic indicator of oxygen redox cycling) have been calculated. From the comparison of E-7(1), K-O2 and k(2), values between the studied nitrofuryl 1,4-DHP derivatives and well-known current drugs an auspicious activity for one of the studied compounds i.e. FDHP2, can be expected.