| Author | dc.contributor.author | Ortíz Yáñez, María Eugenia | |
| Author | dc.contributor.author | Núñez Vergara, Luis | es_CL |
| Author | dc.contributor.author | Camargo Grandón, Rodrigo | es_CL |
| Author | dc.contributor.author | Squella Serrano, Juan | es_CL |
| Admission date | dc.date.accessioned | 2008-09-01T16:26:37Z | |
| Available date | dc.date.available | 2008-09-01T16:26:37Z | |
| Publication date | dc.date.issued | 2004-03 | |
| Cita de ítem | dc.identifier.citation | PHARMACEUTICAL RESEARCH 21(3):428-435 | en |
| Identifier | dc.identifier.issn | 0724-8741 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/120487 | |
| Abstract | dc.description.abstract | The final pyridine derivatives were separated and identified by gas chromatography/ mass spectrometry (GC-MS). The intermediates, anion dihydropyridine and the HO2./HO2- species, were observed from voltammetric studies and controlled potential electrolysis was used to electrogenerate O-2(radial anion).
Results. The current work reveals that electrogenerated superoxide can quantitatively oxidize Hantzsch dihydropyridines to produce the corresponding aromatized pyridine derivatives.
Conclusions. Our results indicate that the aromatization of Hantzsch dihydropyridines by superoxide is initiated by proton transfer from the N1-position on the 1,4-dihydropyridine ring to give the corresponding anion dihydropyridine, which readily undergoes further homogeneous oxidations to provide the final aromatized products. The oxidation of the anionic species of the dihydropyridine is more easily oxidized than the parent compound. | en |
| Lenguage | dc.language.iso | en | en |
| Publisher | dc.publisher | KLUWER ACADEMIC/PLENUM PUBL | en |
| Keywords | dc.subject | Hantzsch dihydropyridines | en |
| Título | dc.title | Oxidation of Hantzsch 1,4-dihydropyridines of pharmacological significance by electrogenerated superoxide | en |
| Document type | dc.type | Artículo de revista | |
