| Author | dc.contributor.author | Tapia, Cristián A. | |
| Author | dc.contributor.author | Ormazabal, Víctor | es_CL |
| Author | dc.contributor.author | Costa, Edda | es_CL |
| Author | dc.contributor.author | Yazdani-Pedram Zobeiri, Mehrdad | es_CL |
| Admission date | dc.date.accessioned | 2009-06-26T10:00:43Z | |
| Available date | dc.date.available | 2009-06-26T10:00:43Z | |
| Publication date | dc.date.issued | 2007-06 | |
| Cita de ítem | dc.identifier.citation | DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, v.: 33, issue: 6, p.: 585-593, JUN 2007. | en |
| Identifier | dc.identifier.issn | 1520-5762 electronic | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/120706 | |
| Abstract | dc.description.abstract | The aim of this work was to develop prolonged diltiazem
hydrochloride release matrices based on alginate-gelatin mixtures and establish
the drug release mechanism. The erosion, swelling, and dissolution behavior
of the tablets in different medium were evaluated. The different polyelectrolyte
behavior and gel strength between type A Gelatin and type B Gelatin
would explain the different swelling, erosion and dissolution behavior in the
media with sudden pH change. The similar dissolution behavior in the pH,
which simulates the physiological pH through the gastrointestinal tract,
should be explained because the same main species for gelatin A and Gelatin
B would be present in this media. | en |
| Patrocinador | dc.description.sponsorship | This work was partially funded by FONDECYT
grant N° 1981405. | en |
| Lenguage | dc.language.iso | en | en |
| Publisher | dc.publisher | TAYLOR & FRANCIS INC | |
| Keywords | dc.subject | Alginate | en |
| Título | dc.title | Study of Dissolution Behavior of Matrices Tablets Based on Alginate—Gelatin Mixtures as Prolonged Diltiazem Hydrochloride Release Systems | en |
| Document type | dc.type | Artículo de revista | |
