| Author | dc.contributor.author | Letelier Muñoz, María Eugenia | |
| Author | dc.contributor.author | Aracena Parks, Paula | es_CL |
| Author | dc.contributor.author | Peredo Silva, Liliana | es_CL |
| Admission date | dc.date.accessioned | 2010-06-22T12:51:18Z | |
| Available date | dc.date.available | 2010-06-22T12:51:18Z | |
| Publication date | dc.date.issued | 2010 | |
| Cita de ítem | dc.identifier.citation | Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas Vol.9 (1) 2010, pp. 69-79 | en_US |
| Identifier | dc.identifier.issn | 0717-7917 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/121011 | |
| Abstract | dc.description.abstract | Herbal extracts must be evaluated for their efficacy and safety. In vivo acute toxicity studies must consider the different mechanisms by which active compounds may elicit toxicological outcomes. Thus, a methodology to test general parameters related to acute toxicity responses in a murine model was developed, using a Saw Palmetto extract (HiPower®): adult male Sprague-Dawley rats were treated orally with two doses of HiPower® (the recommended dose for humans and a dose 10-fold higher) for 10 days, to examine general homeostatic parameters (hemogram and clinical chemistry) as well as morphological features of tissues involved in the response to xenobiotics (liver, kidney, spleen, and lymphatic ganglia). None of the parameters analyzed underwent significant changes during treatment, suggesting that HiPower® displays a good safety profile for the period tested. This method may be adopted for testing the in vivo acute toxicity of herbal extracts. | en_US |
| Patrocinador | dc.description.sponsorship | This work was supported by Madreselva Producción y Desarrollo Ltda. (Santiago, Chile). | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Keywords | dc.subject | Saw Palmetto | en_US |
| Título | dc.title | A protocol for evaluating the safety of herbal preparations in a rat model: the case of a supercritical fluid extract of Saw Palmetto | en_US |
| Title in another language | dc.title.alternative | Un protocolo para evaluar la seguridad de preparaciones herbales en un modelo de ratas: el caso de un extracto fluido supercrítico de Saw Palmetto | en_US |
| Document type | dc.type | Artículo de revista | |
