Polarographic study of nifurtimox

Author	dc.contributor.author	Squella Serrano, Juan
Author	dc.contributor.author	Muñoz, W.	es_CL
Author	dc.contributor.author	Núñez Vergara, Luis	es_CL
Author	dc.contributor.author	Paulos, Claudio	es_CL
Admission date	dc.date.accessioned	2011-06-01T19:52:01Z
Available date	dc.date.available	2011-06-01T19:52:01Z
Publication date	dc.date.issued	1990
Cita de ítem	dc.identifier.citation	JOURNAL OF PHARMACEUTICAL SCIENCES 79 (9): 837-839	es_CL
Identifier	dc.identifier.issn	0022-3549
Identifier	dc.identifier.uri	https://repositorio.uchile.cl/handle/2250/121220
General note	dc.description	Artículo de publicación ISI.	es_CL
Abstract	dc.description.abstract	Nifurtimox is polarographically reducible over the whole pH range, the nitro group being reduced to the hydroxylamine group in a 4ē process and subsequently the amine being formed in a 2ē process at a pH value below 4. The C=N-N linkage is reduced by a mechanism involving reductive fission of the N-N bond. The differential pulse polarographic peaks for the reduction of the nitro group to the hydroxylamine group at pH 6 were used in developing a new polarographic method for the determination of nifurtimox in pharmaceutical forms.	es_CL
Lenguage	dc.language.iso	en	es_CL
Publisher	dc.publisher	AMER PHARMACEUTICAL ASSN	es_CL
Keywords	dc.subject	NIFURTIMOX	es_CL
Título	dc.title	Polarographic study of nifurtimox	es_CL
Document type	dc.type	Artículo de revista