| Author | dc.contributor.author | Maza Cave, María Pía de la | es_CL |
| Author | dc.contributor.author | Uribarri, Jaime | es_CL |
| Author | dc.contributor.author | Olivares, Daniela | es_CL |
| Author | dc.contributor.author | Hirsch Birn, Sandra | es_CL |
| Author | dc.contributor.author | Leiva Balich, Laura | es_CL |
| Author | dc.contributor.author | Barrera Acevedo, María Gladys | |
| Author | dc.contributor.author | Bunout Barnett, Daniel | es_CL |
| Admission date | dc.date.accessioned | 2010-01-27T20:37:16Z | |
| Available date | dc.date.available | 2010-01-27T20:37:16Z | |
| Publication date | dc.date.issued | 2008-12 | |
| Cita de ítem | dc.identifier.citation | REJUVENATION RESEARCH, Volume: 11, Issue: 6, Pages: 1041-1048, 2008 | en_US |
| Identifier | dc.identifier.issn | 1549-1684 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/123950 | |
| Abstract | dc.description.abstract | Background: Tissue accumulation of advanced glycation end products (AGEs) is associated with ageing, both
in diabetics and nondiabetic subjects.
Aim: The purpose of this study was to assess immunostaining for AGEs, specifically carboxymethyl-lysine
(CML) and receptor for AGEs (RAGE), in muscle tissue of healthy male subjects differing in age and weight
stability.
Methodology: Muscle tissue was obtained during hernia surgery in middle-aged men reporting weight maintenance
(WM, n 10) or weight gain (WG, n 7), and also in 4 elderly men. Tissue inmunostaining for CML
and RAGE was performed.
Results: Intensity of CML and RAGE staining were highly correlated (r 0.84) and also significantly associated
with weight change and age. Muscle AGEs accretion was statistically associated with muscle expression
of oxidative injury (8–hydroxy-deoxyguanosine and 4-hydroxy-2-nonenal) and inflammatory markers (tumor
necrosis factor- ).
Discussion: The increase of skeletal muscle AGEs/RAGE and markers of inflammation and oxidative injury in
association with weight gain and old age suggest a pathogenic role of AGEs in weight gain and in sarcopenia
of aging. | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | MARY ANN LIEBERT INC | en_US |
| Keywords | dc.subject | CALORIE RESTRICTION | en_US |
| Título | dc.title | Weight Increase Is Associated with Skeletal Muscle Immunostaining for Advanced Glycation End Products, Receptor for Advanced Glycation End Products, and Oxidation Injury | en_US |
| Document type | dc.type | Artículo de revista | |
