Descripción de los hallazgos en el perfil lipídico y proteico de pacientes dependientes a cocaína, en abstinencia reciente
Author
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Massardo Vega, Lucía
Author
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Araya, A. Verónica
Author
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Ibáñez, Carlos
Author
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Véliz Uribe, Jonathan
Author
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Fernández, René
Author
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Jaimovich, Rodrigo
Author
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Pallavicini, Julio
Author
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Chandía, Rolando
Author
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Pereira, Karla
Author
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Pereira, Jaime
Admission date
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2015-10-19T20:14:33Z
Available date
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2015-10-19T20:14:33Z
Publication date
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2015
Cita de ítem
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Rev Med Chile 2015; 143: 697-706
en_US
Identifier
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0034-9887
Identifier
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https://repositorio.uchile.cl/handle/2250/134483
General note
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Artículo de publicación ISI
en_US
Abstract
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Background: Chronic cocaine users develop multiple potentially lethal ischemic
vascular complications associated with accelerated atherosclerosis. Aim: To
assess biochemical and lipid profiles among cocaine dependent subjects in recent
abstinence. Material and Methods: A blood sample to measure blood count,
biochemical and lipid profiles was obtained from 78 patients aged 19 to 53 years
(78% males) who complied with DSM-IV criteria for cocaine dependency. Laboratory
results were compared with a group of normal subjects. Results: All cases
had positive urinary cocaine, with a mean consumption lapse of 7.6 years. The
frequency of smoking was higher in cases. Dependent males had higher body mass
index than controls. Compared to controls, dependent females had significantly
higher triglyceride (TG) levels and lower HDL cholesterol. Therefore the relation
total/HDL cholesterol was higher (p = 0.0365). Dependent males had higher TG
levels than their normal counterparts. Dependent subjects consuming cocaine
base-paste had higher TG levels. Total proteins, albumin, urea and blood urea
nitrogen were lower in dependent subjects. Among males, serum creatinine was
lower and blood urea was positively correlated with the daily amount of cocaine
use (p = 0.03). After a month of strict abstinence, lipid profile was repeated in
27 patients and remained unchanged. Conclusions: Chronic cocaine use was
associated with higher TG in both genders and lower HDL cholesterol in women
when compared with a group of healthy counterparts.