Ultra-high-performance liquid chromatography-Time-of-flight high resolution mass spectrometry to quantify acidic drugs in wastewater
Author
dc.contributor.author
Becerra Herrera, Mercedes
Author
dc.contributor.author
Honda, Luis
Author
dc.contributor.author
Richter Duk, Pablo
Admission date
dc.date.accessioned
2016-01-12T15:15:58Z
Available date
dc.date.available
2016-01-12T15:15:58Z
Publication date
dc.date.issued
2015
Cita de ítem
dc.identifier.citation
Journal of Chromatography A, 1423 (2015) 96–103
en_US
Identifier
dc.identifier.other
DOI: 10.1016/j.chroma.2015.10.071
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/136401
General note
dc.description
Artículo de publicación ISI
en_US
Abstract
dc.description.abstract
A novel analytical approach involving an improved rotating-disk sorptive extraction (ROSE) procedure and ultra-high-performance liquid chromatography (UHPLC) coupled to an ultraspray electrospray ionization source (UESI) and time-of-flight mass spectrometry (TOF/MS), in trap mode, was developed to identify and quantify four non-steroidal anti-inflammatory drugs (NSAIDs) (naproxen, ibuprofen, ketoprofen and diclofenac) and two anti-cholesterol drugs (ACDs) (clofibric acid and gemfibrozil) that are widely used and typically found in water samples. The method reduced the amount of both sample and reagents used and also the time required for the whole analysis, resulting in a reliable and green analytical strategy. The analytical eco-scale was calculated, showing that this methodology is an excellent green analysis, increasing its ecological worth. The detection limits (LOD) and precision (%RSD) were lower than 90 ng/L and 10%, respectively. Matrix effects and recoveries were studied using samples from the influent of a wastewater treatment plant (WWTP). All the compounds exhibited suppression of their signals due to matrix effects, and the recoveries were approximately 100%. The applicability and reliability of this methodology were confirmed through the analysis of influent and effluent samples from a WWTP in Santiago, Chile, obtaining concentrations ranging from 1.1 to 20.5 mu g/L and from 0.5 to 8.6 mu g/L, respectively.