International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries
Author
dc.contributor.author
McCormack, Valerie
Author
dc.contributor.author
Burton, Anya
Author
dc.contributor.author
Santos Silva, Isabel dos
Author
dc.contributor.author
Hipwell, John
Author
dc.contributor.author
Dickens, Caroline
Author
dc.contributor.author
Salem, Dorria
Author
dc.contributor.author
Kama, Rasha
Author
dc.contributor.author
Hartman, Mikael
Author
dc.contributor.author
Lee, Charmaine Pei Ling
Author
dc.contributor.author
Chiah, Kee-Seng
Author
dc.contributor.author
Ozmen, Vahit
Author
dc.contributor.author
Aribal, Mustafa Erkin
Author
dc.contributor.author
Flugelman, Anath Arzee
Author
dc.contributor.author
Lajous, Martín
Author
dc.contributor.author
López Riduara, Ruy
Author
dc.contributor.author
Rice, Megan
Author
dc.contributor.author
Romieun, Isabelle
Author
dc.contributor.author
Ursin, Giske
Author
dc.contributor.author
Qureshi, Samera
Author
dc.contributor.author
Ma, Huiyan
Author
dc.contributor.author
Lee, Eunjung
Author
dc.contributor.author
van Gils, Carla
Author
dc.contributor.author
Wanders, Johanna
Author
dc.contributor.author
Vinayak, Sudhir
Author
dc.contributor.author
Ndumia, Rose
Author
dc.contributor.author
Allen, Steve
Author
dc.contributor.author
Vinnicombe, Sarah
Author
dc.contributor.author
Moss, Sue
Author
dc.contributor.author
Lee, Jong Won
Author
dc.contributor.author
Kim, Jisun
Author
dc.contributor.author
Pereira Scalabrino, Ana
Author
dc.contributor.author
Garmendia Miguel, María Luisa
Author
dc.contributor.author
Sirous, Reza
Author
dc.contributor.author
Sirous, Mehri
Author
dc.contributor.author
Peplonska, Beata
Author
dc.contributor.author
Bukowska, Agnieszka
Author
dc.contributor.author
Tamimi, Rulla
Author
dc.contributor.author
Bertrand, Kimberly
Author
dc.contributor.author
Nagata, Chisato
Author
dc.contributor.author
Kwong, Ava
Author
dc.contributor.author
Vachon, Celine
Author
dc.contributor.author
Scott, Christopher
Author
dc.contributor.author
Pérez Gómez, Beatriz
Author
dc.contributor.author
Pollan, Marina
Author
dc.contributor.author
Maskarinec, Gertraud
Author
dc.contributor.author
Giles, Graham
Author
dc.contributor.author
Hopper, John
Author
dc.contributor.author
Stone, Jennifer
Author
dc.contributor.author
Rajaram, Nadia
Author
dc.contributor.author
Teo, Soo Hwang
Author
dc.contributor.author
Mariapun, Shivaani
Author
dc.contributor.author
Yaffe, Martín
Author
dc.contributor.author
Schuez, Joachim
Author
dc.contributor.author
Chiarelli, Anna
Author
dc.contributor.author
Linton, Linda
Author
dc.contributor.author
Boyd, Norman
Admission date
dc.date.accessioned
2016-06-16T22:54:03Z
Available date
dc.date.available
2016-06-16T22:54:03Z
Publication date
dc.date.issued
2016
Cita de ítem
dc.identifier.citation
Cancer Epidemiology 40 (2016) 141–151
en_US
Identifier
dc.identifier.other
DOI: 10.1016/j.canep.2015.11.015
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/138935
General note
dc.description
Articulo de publicación ISI
en_US
Abstract
dc.description.abstract
Mammographic density (MD) is a quantitative trait, measurable in all women, and is among the strongest markers of breast cancer risk. The population-based epidemiology of MD has revealed genetic, lifestyle and societal/environmental determinants, but studies have largely been conducted in women with similar westernized lifestyles living in countries with high breast cancer incidence rates. To benefit from the heterogeneity in risk factors and their combinations worldwide, we created an International Consortium on Mammographic Density (ICMD) to pool individual-level epidemiological and MD data from general population studies worldwide. ICMD aims to characterize determinants of MD more precisely, and to evaluate whether they are consistent across populations worldwide. We included 11755 women, from 27 studies in 22 countries, on whom individual-level risk factor data were pooled and original mammographic images were re-read for ICMD to obtain standardized comparable MD data. In the present article, we present (i) the rationale for this consortium; (ii) characteristics of the studies and women included; and (iii) study methodology to obtain comparable MD data from original re-read films. We also highlight the risk factor heterogeneity captured by such an effort and, thus, the unique insight the pooled study promises to offer through wider exposure ranges, different confounding structures and enhanced power for sub-group analyses.
en_US
Patrocinador
dc.description.sponsorship
Israel-The Israel Cancer Association; Rep. of Korea - Asan Medical Center, Seoul 2010-0811; Malaysia - Sime Darby LPGA Tournament; Ministry of Education University Malaya High Impact Research UM.C/HIR/MOHE/06; National Council of Science and Technology (Mexico); American Institute for Cancer Research 10A035; Netherlands EPIC-NL-Europe against Cancer Programme of the European Commission (SANCO); Dutch Ministry of Health; Dutch Cancer Society; ZonMW the Netherlands Organisation for Health Research and Development; World Cancer Research Fund (WCRF); Poland - Polish-Norwegian Research Programme NRF-243-AI-1/07; Singapore - Clinician Scientist Award from National Medical Research Council; National University Cancer Institute Singapore (NCIS) Centre grant programme from National Medical Research Council; South Africa - Pink Drive; Spain - Spain's Health Research Fund (Fondo de Investigacion Santiaria) PI060386, PI09/0790; Spanish Federation of Breast Cancer Patients (FECMA) EPY1169-10; Turkey - Roche Mustahzarlari San. A.S., Istanbul, Turkey; UK: EPSRC EP/K020439/1; Breast Cancer Campaign 2007MayPR23; Cancer Research UK G186/11; Da Costa Foundation ; US - National Cancer Institute R01CA85265, R37CA54281, R01CA97396, P50CA116201, R01CA177150, R01CA140286; Cancer Center Support Grant CA15083, CA131332, CA124865, UM1CA186107, UM1CA176726; Susan G. Komen Foundation