β-Adrenoceptor blockade depresses molecular and functional plasticities in the rat neocortex
Author
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Flores, Osvaldo
Author
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Núñez, Héctor
Author
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Pérez, Hernán
Author
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Morgan, Carlos
Author
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Soto Moyano, Rubén
Author
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Valladares Boasi, Luis
Author
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Burgos, Héctor
Author
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Olivares, Ricardo
Author
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Hernández, Alejandro
Admission date
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2018-12-20T14:12:44Z
Available date
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2018-12-20T14:12:44Z
Publication date
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2010
Cita de ítem
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Brain Research Bulletin, Volumen 82, Issue 5-6, 2018, Pages 284-288
Identifier
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03619230
Identifier
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10.1016/j.brainresbull.2010.05.010
Identifier
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https://repositorio.uchile.cl/handle/2250/154787
Abstract
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β-Adrenergic receptor stimulation can significantly facilitate synaptic potentiation in the hippocampus and enhance memory processes, but its effect on neocortical plastic mechanisms is less conclusive. In the present study we determined the effect of propranolol, a β-adrenoceptor antagonist, on long-term potentiation (LTP) induced in vivo in rat occipital cortex by tetanizing stimulation of corpus callosum and observed a dose-dependent inhibition of LTP. We further administered propranolol through mini-osmotic pumps during 3 days, and observed the performance of rats in a complex operant conditioning learning paradigm and assessed the expression of brain-derived neurotrophic factor (BDNF) in the occipital cortex. Propranolol exposure depressed both the number of reinforced responses in the operant conditioning task and BDNF expression in occipital cortex. Taken together, our results suggest that propranolol impairs memory formation by inhibiting cortical LTP induction and associated B