Posteriorization by FGF, Wnt, and retinoic acid is required for neural crest induction
Artículo
Open/ Download
Access note
Acceso Abierto
Publication date
2002Metadata
Show full item record
Cómo citar
Villanueva, Sandra
Cómo citar
Posteriorization by FGF, Wnt, and retinoic acid is required for neural crest induction
Abstract
The neural crest is a unique cell population induced at the lateral border of the neural plate. Neural crest is not produced at the anterior border of the neural plate, which is fated to become forebrain. Here, the roles of BMPs, FGFs, Wnts, and retinoic acid signaling in neural crest induction were analyzed by using an assay developed for investigating the posteriorization of the neural plate. Using specific markers for the anterior neural plate border and the neural crest, the posterior end of early neurula embryos was shown to be able to transform the anterior neural plate border into neural crest cells. In addition, tissue expressing anterior neural plate markers, induced by an intermediate level of BMP activity, was transformed into neural crest by posteriorizing signals. This transformation was mimicked by bFGF, Wnt-8, or retinoic acid treatment and was also inhibited by expression of the dominant negative forms of the FGF receptor, the retinoic acid receptor, and Wnt signaling m
Indexation
Artículo de publicación SCOPUS
Identifier
URI: https://repositorio.uchile.cl/handle/2250/156016
DOI: 10.1006/dbio.2001.0485
ISSN: 00121606
Quote Item
Developmental Biology, Volumen 241, Issue 2, 2018, Pages 289-301
Collections