Baveno VI and Expanded Baveno VI criteria successfully predicts the absence of high-risk gastro-oesophageal varices in a chilean cohort
Author
dc.contributor.author
Gaete, María I.
Author
dc.contributor.author
Díaz, Luis
Author
dc.contributor.author
Arenas, Alex
Author
dc.contributor.author
González Lagos, Katherine
Author
dc.contributor.author
Cattaneo Buteler, Máximo
Admission date
dc.date.accessioned
2020-04-22T16:14:07Z
Available date
dc.date.available
2020-04-22T16:14:07Z
Publication date
dc.date.issued
2020
Cita de ítem
dc.identifier.citation
Liver International. 2020;00:1–8.
es_ES
Identifier
dc.identifier.issn
1478-3223
Identifier
dc.identifier.other
10.1111/liv.14373
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/174017
Abstract
dc.description.abstract
Background: Baveno VI and expanded Baveno VI criteria have been recommended to
circumvent the need for endoscopy screening in patients with a very low probability
of varices needing treatment (VNT).
Aim: To validate these criteria in a Latin American population.
Methods: The ability of Baveno VI criteria (liver stiffness measurement (LSM) <20 kPa
and platelet count >150 × 103/μL) and expanded Baveno VI criteria (LSM < 25kPa and
platelet count >110 × 103/μL) to exclude the presence of VNT was tested in a prospectively recruited cohort of patients with Child-Pugh A liver cirrhosis and with no previous
variceal haemorrhage who attended the liver clinics of three major hospitals in Chile.
Results: Three hundred patients were included. The median (IQR) age was 61 [18-86]
years, median MELD was 8.0 (6-17), median LSM was 17.2 (10.2-77) kPa and median
platelet count was 137 (23-464) × 103
/μL. The main aetiology was non-alcoholic fatty
liver disease (67.3%). VNT were present in 18% of patients. The Baveno VI criteria
had a sensitivity of 98.1% and a specificity of 38.2%, potentially sparing 31.3% of
upper endoscopies with a very low risk of missing VNT (1.1%). The expanded Baveno
VI criteria had a sensitivity of 90.7% and a specificity of 61%, potentially sparing
51.3% of upper endoscopies with a risk of missing VNT of 3.6%. Both criteria were
independently associated with the absence of VNT.
Conclusion: We validated the Baveno VI and expanded Baveno VI criteria in Chilean
population, potentially sparing 31.3% and 51.3% of endoscopies, respectively, with a
very low risk of missing VNT. Fondecyt 1191183
es_ES
Patrocinador
dc.description.sponsorship
Chilean government through Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
1119145
1200227
1191183
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT PIA/BASAL
CONICYT PIA/Basal PFB12