Chitosan-pluronic based Cu nanocomposite hydrogels for prototype antimicrobial applications
Author
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Jayaramudu, Tippabattini
Author
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Varaprasad, Kokkarachedu
Author
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Koteshwara Reddy, K.
Author
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Pyarasani, Radha D.
Author
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Akbari Fakhrabadi, Ali
Author
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Amalraj, John
Admission date
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2020-05-05T22:46:57Z
Available date
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2020-05-05T22:46:57Z
Publication date
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2020
Cita de ítem
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International Journal of Biological Macromolecules 143 (2020) 825–832
es_ES
Identifier
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10.1016/j.ijbiomac.2019.09.143
Identifier
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https://repositorio.uchile.cl/handle/2250/174411
Abstract
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Copper nanoparticles were synthesized via precipitation technique using the pseudonatural cationic chitosan biopolymer as a stabilizing agent. The nanoparticles developed were successfully incorporated into the 1:1 ratio of blended chitosan: pluronic F127 polymer solution and made their nanocomposite hydrogels by solution casting method. The formed copper-based nanocomposite hydrogels were characterized by using Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, scanning electron microscopy-energy dispersive spectroscopy and transmission electron microscopy studies. The antimicrobial activity of the fabricated nanocomposite hydrogels was tested via an inhibition zone process against both E. coli (gram-negative) and S. aureus (gram-positive) bacteria. The results conveyed that the copper-embedded chitosan-pluronic\ F127 nanocomposite hydrogels can be used effectively for antimicrobial applications as well as for wound care applications.
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Patrocinador
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Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT), CONICYT FONDECYT: 3170272, 11160073
Universidad de Talca, Talca, Chile
Proyecto de Investigacion enlace FONDECYT Universidad de Talca: 300061
CIPA, CONICYT Regional, GORE BIO-BIO: R17A10003