| Author | dc.contributor.author | Díaz Vegas, Alexis | |
| Author | dc.contributor.author | Sánchez Aguilera, Pablo | |
| Author | dc.contributor.author | Krycer, James R | |
| Author | dc.contributor.author | Morales, Pablo E. | |
| Author | dc.contributor.author | Monsalves Álvarez, Matías | |
| Author | dc.contributor.author | Cifuentes Koster, Mariana | |
| Author | dc.contributor.author | Rothermel, Beverly A. | |
| Author | dc.contributor.author | Lavandero González, Sergio | |
| Admission date | dc.date.accessioned | 2020-08-13T23:24:35Z | |
| Available date | dc.date.available | 2020-08-13T23:24:35Z | |
| Publication date | dc.date.issued | 2020 | |
| Cita de ítem | dc.identifier.citation | Endocrine Reviews 41(3):491-517 (2020) | es_ES |
| Identifier | dc.identifier.other | 10.1210/endrev/bnaa005 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/176420 | |
| Abstract | dc.description.abstract | Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. Here, we discuss the role of mitochondria in maintaining cellular and whole-organism homeostasis, the mechanisms that promote mitochondrial dysfunction, and the role of this phenomenon in noncommunicable chronic diseases. We also review the state of the art regarding the preclinical evidence associated with the regulation of mitochondrial function and the development of current mitochondria-targeted therapeutics to treat noncommunicable chronic diseases. Finally, we give an integrated vision of how mitochondrial damage is implicated in these metabolic diseases. | es_ES |
| Patrocinador | dc.description.sponsorship | Agencia Nacional de Investigación y Desarrollo (ANID), Chile
FONDECYT 1161156
FONDECYT 1200490
FONDAP 15130011
Comisión Nacional de Investigación Científica y Tecnológica (CONICYT)
American Heart Association
19TPA34920001
United States Department of Health & Human Services
National Institutes of Health (NIH) - USA
RO1HD101006
National Health and Medical Research Council of Australia
APP1142403
VID, Universidad de Chile
ENL 18/19
Australian Research Council
DP180103482 | es_ES |
| Lenguage | dc.language.iso | en | es_ES |
| Publisher | dc.publisher | Endocrine Society | es_ES |
| Source | dc.source | Endocrine Reviews | es_ES |
| Keywords | dc.subject | Mitochondria | es_ES |
| Keywords | dc.subject | Obesity | es_ES |
| Keywords | dc.subject | Insulin resistance | es_ES |
| Keywords | dc.subject | Cancer | es_ES |
| Keywords | dc.subject | Cardiovascular diseases | es_ES |
| Título | dc.title | Is mitochondrial dysfunction a common root of noncommunicable chronic diseases? | es_ES |
| Document type | dc.type | Artículo de revista | es_ES |
| dcterms.accessRights | dcterms.accessRights | Acceso a solo metadatos | es_ES |
| Cataloguer | uchile.catalogador | ctc | es_ES |
| Indexation | uchile.index | Artículo de publicación ISI | |
| Indexation | uchile.index | Artículo de publicación SCOPUS | |
