Synthesis, Docking, 3-D-Qsar, and Biological Assays of Novel Indole Derivatives Targeting Serotonin Transporter, Dopamine D2 Receptor, and Mao-A Enzyme: In the Pursuit for Potential Multitarget Directed Ligands
Author
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Cerda Cavieres, Christopher David
Author
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Quiroz, Gabriel
Author
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Iturriaga-Vásquez, Patricio
Author
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Rodríguez Lavado, Julio
Author
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Alarcón Espósito, Jazmín
Author
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Saitz Barría, Claudio
Author
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Pessoa Mahana, Carlos D.
Author
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Chung, Hery
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Araya Maturana, Ramiro
Author
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Mella Raipán, Jaime A.
Author
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Cabezas, David
Author
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Ojeda Gómez, Claudia
Author
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Reyes Parada, Miguel
Author
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Pessoa Mahana, Hernán
Admission date
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2021-04-06T21:46:22Z
Available date
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2021-04-06T21:46:22Z
Publication date
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2020
Cita de ítem
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Molecules 2020, 25, 4614
es_ES
Identifier
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10.3390/molecules25204614
Identifier
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https://repositorio.uchile.cl/handle/2250/178967
Abstract
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A series of 27 compounds of general structure 2,3-dihydro-benzo[1,4]oxazin-4-yl)-2-{4-[3-(1H-3indolyl)-propyl]-1-piperazinyl}-ethanamides, Series I: 7(a-o) and (2-{4-[3-(1H-3-indolyl)-propyl]-1-piperazinyl}-acetylamine)-N-(2-morfolin-4-yl-ethyl)-fluorinated benzamides Series II: 13(a-l) were synthesized and evaluated as novel multitarget ligands towards dopamine D-2 receptor, serotonin transporter (SERT), and monoamine oxidase-A (MAO-A) directed to the management of major depressive disorder (MDD). All the assayed compounds showed affinity for SERT in the nanomolar range, with five of them displaying Ki values from 5 to 10 nM. Compounds 7k, Ki = 5.63 +/- 0.82 nM, and 13c, Ki = 6.85 +/- 0.19 nM, showed the highest potencies. The affinities for D-2 ranged from micro to nanomolar, while MAO-A inhibition was more discrete. Nevertheless, compounds 7m and 7n showed affinities for the D-2 receptor in the nanomolar range (7n: Ki = 307 +/- 6 nM and 7m: Ki = 593 +/- 62 nM). Compound 7n was the only derivative displaying comparable affinities for SERT and D-2 receptor (D-2/SERT ratio = 3.6) and could be considered as a multitarget lead for further optimization. In addition, docking studies aimed to rationalize the molecular interactions and binding modes of the designed compounds in the most relevant protein targets were carried out. Furthermore, in order to obtain information on the structure-activity relationship of the synthesized series, a 3-D-QSAR CoMFA and CoMSIA study was conducted and validated internally and externally (q(2) = 0.625, 0.523 for CoMFA and CoMSIA and r(ncv)(2) = 0.967, 0.959 for CoMFA and CoMSIA, respectively).
es_ES
Patrocinador
dc.description.sponsorship
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT
1170269
1170662
3180602
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
Synthesis, Docking, 3-D-Qsar, and Biological Assays of Novel Indole Derivatives Targeting Serotonin Transporter, Dopamine D2 Receptor, and Mao-A Enzyme: In the Pursuit for Potential Multitarget Directed Ligands