Reproducibility of global LV function and dyssynchrony parameters derived from phase analysis of gated myocardial perfusion SPECT: A multicenter comparison with core laboratory setting
Author
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De Amorím Fernández, Fernando
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Peix, Amalia
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Giubbini, Raffaele
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Karthikeyan, Ganesan
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Massardo Vega, Teresa
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Patel, Chetan
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Pabón, Luz M.
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Jiménez Heffernan, Amelia
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Alexanderson, Erick
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Butt, Sadaf
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Kumar, Alka
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Marín, Víctor
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Morozova, Olga
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Páez, Diana
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Mesquita, Claudio T.
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García, Ernest
Admission date
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2021-04-20T19:41:55Z
Available date
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2021-04-20T19:41:55Z
Publication date
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2020
Cita de ítem
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Journal of Nuclear Cardiology (2020)
es_ES
Identifier
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10.1007/s12350-020-02397-6
Identifier
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https://repositorio.uchile.cl/handle/2250/179191
Abstract
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Background Gated myocardial perfusion scintigraphy (GMPS) phase analysis is an important tool to investigate the physiology of left ventricular (LV) dyssynchrony. We aimed to test the performance of GMPS LV function and phase analysis in different clinical settings and on a diverse population. Methods This is a post hoc analysis of a prospective, non-randomized, multinational, multicenter cohort study. Clinical evaluation and GMPS prior to cardiac resynchronization therapy (CRT)(baseline) and 6-month post CRT (follow-up) were done. LV end-systolic volume (LVESV), LV end-diastolic volume (LVEDV), LV ejection fraction (LVEF), LV phase standard deviation (LVPSD), and percentage of left ventricle non-viable (PLVNV) were obtained by 10 centers and compared to the core lab. Results 276 GMPS studies had all data available from individual sites and from core lab. There were no statistically significant differences between all variables except for LVPSD. When subjects with no mechanical dyssynchrony were excluded, LVPSD difference became non-significant. LVESV, LVEF, LVPSD and PLVNV had strong correlation in site against core lab comparison. Bland-Altman plots demonstrated good agreement. Conclusions The presented correlation and agreement of LV function and dyssynchrony analysis over different sites with a diverse sample corroborate the strength of GMPS in the management of heart failure in clinical practice.
Reproducibility of global LV function and dyssynchrony parameters derived from phase analysis of gated myocardial perfusion SPECT: A multicenter comparison with core laboratory setting