From Mulinum crassifolium Phil, collected on the western flank in northern Chile, was isolated mulin-11,13-dien-20-oic acid and a new diterpenoid, 17-acetoxymulin-11,13-dien-20-oic acid 2. Its structure was established by ...

Transcription factor NF-κB plays a key role in the inducible expression of genes mediating proinflammatory effects, and is thus an important target for the development of antiinflammatory drugs. Laretia acaulis (Cav.) Gill ...

A new diterpenoid, azorellanol (5), was isolated from the whole plant of Azorella compacta (Umbelliferae). The stricture was established by using mainly one- and two-dimensional NMR techniques, whereas the absolute ...

Diterpenoids with trichomonicidal activity were isolated from the aerial parts of Azorella yareta Hauman. One was 13β-hydroxyazorellane, together with the known constituents mulinolic acid, mulin-11,13-dien-20-oic acid, ...

Background: Obesity is a major health problem associated with increased comorbiditics, which are partially triggered by inflammation. Proinflaminatory macrophage infiltration in adipose tissue of individuals with obesity ...

Two mulinane-type diterpenoids were isolated from Azorella compacta; namely 20-hydroxymulin-11,13-dienyl acetate and 13,14-dihydroxymulin-11-en-20-oic acid. The structures were elucidated by analysis of their spectroscopic ...

Background: Obesity is strongly associated with insulin resistance (IR). IR at the molecular level may bedefined as a diminished activation of insulin signaling-related molecules (IRS-1/Akt/AS160) as well asreduced glucose ...