Azorellane diterpenoids from laretia acaulis, and its toxoplasmacidal activity

Abstract

In addition to azorellanol a new diterpenoid 7-deacetylazorellanol, has been isolated from the aerial parts oiLaretia acaulis (Cav.) Gill et Hook (Umbelliferae). Its structure was based on spectroscopic comparison with azorellanol and chemical grounds. Azorellanol and 7-deacetylazorellanol showed marked inhibitor activity against trophozoites of protozoan parasite Toxoplasma gondii. The 50 % inhibitory dose for azorellanol was calculated in 54 nM and for 7-deacetylazorellanol was 42 nM.