Browsing by Author "1a297a98-4876-4a1f-8921-c55a9d1cad9e"

Now showing items 61-74 of 74

    • Sjögren’s syndrome and the epithelial target: A comprehensive review 
      Barrera, M. J.; Bahamondes Cornejo, Valeria Cristina; Sepúlveda, D.; Quest, Andrew F. G.; Castro, I.; Cortés, J.; Aguilera, S.; Urzúa Tobar, Ulises; Molina, C.; Pérez, P.; Ewert, P.; Alliende, C.; Hermoso Ramello, Marcela; González, S.; Leyton Blanca, Cristina; González, M. J. (Elsevier, 2013)
      The most difficult component in our understanding of human autoimmunity remains a rigorous dissection of etiological events. Indeed, the vast literature on autoimmune diseases focuses on the inflammatory response, with ...
    • Src-family kinase inhibitors block early steps of caveolin-1-enhanced lung metastasis by melanoma cells 
      Ortiz, Rina; Díaz, Jorge; Díaz Valdivia, Natalia; Martínez Meza, Samuel; Simón, Layla; Contreras Orellana, Pamela; Lobos González, Lorena; Guerrero, Simón; Leyton Campos, Lisette; Quest, Andrew F. G. (Elsevier, 2020)
      In advanced stages of cancer disease, caveolin-1 (CAV1) expression increases and correlates with increased migratory and invasive capacity of the respective tumor cells. Previous findings from our laboratory revealed that ...
    • Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014-2024 
      Ferreccio, Catterina; Roa, Juan Carlos; Bambs, Claudia; Vives, Alejandra; Corvalán, Alejandro H.; Cortés, Sandra; Foerster, Claudia; Acevedo, Johanna; Huidobro, Andrea; Passi, Alvaro; Toro, Pablo; Covacevich, Yerko; Cruz, Rolando de la; Koshiol, Jill; Olivares, Mauricio; Miquel, Juan Francisco; Cruz, Francisco; Silva, Raúl; Quest, Andrew F. G.; Kogan Bocian, Marcelo; Castro, Pablo F.; Lavandero González, Sergio (BioMed Central, 2016)
      Background: Maule Cohort (MAUCO), a Chilean cohort study, seeks to analyze the natural history of chronic diseases in the agricultural county of Molina (40,000 inhabitants) in the Maule Region, Chile. Molina's population ...
    • Sub cytotoxic doses of anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis ... 
      Díaz, N.; Leyton Campos, Lisette; Quest, Andrew F. G. (Wiley, 2017)
    • Syndecan-4 strengthens the effect of integrin on CD90 induced cellular contraction 
      Burgos Bravo, F.; Wilson Moya, Christian; Quest, Andrew F. G.; Leyton Campos, Lisette (Wiley, 2017)
    • Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells 
      Valdivia Hepp, Juan; Cárdenas, Areli; Brenet, Marianne; Maldonado, Horacio; Kong, Milene; Díaz Jara, Jorge; Burridge, Keith; Schneider, Pascal; San Martín, Alejandra; García Mata, Rafael; Quest, Andrew F. G.; Leyton, Lisette (BMC, 2020)
      Background: Syndecans regulate cell migration thus having key roles in scarring and wound healing processes. Our previous results have shown that Thy-1/CD90 can engage both alpha v beta 3 integrin and Syndecan-4 expressed ...
    • The 5’ untranslated region of the anti-apoptotic protein Survivin contains an inhibitory upstream AUG codon 
      Palavecino, Christian E.; Carrasco Véliz, Nicolás; Quest, Andrew F.G.; Garrido Palma, Maritza P.; Valenzuela Valderrama, Manuel (Elsevier, 2020)
      Survivin (BIRC5) is an anti-apoptotic protein that is important in cancer. Mechanisms responsible for controlling Survivin levels in cells include transcriptional regulation and modulation of protein stability via ...
    • The non-receptor tyrosine phosphatase type 14 blocks caveolin-1- enhanced cancer cell metastasis 
      Díaz Valdivia, Natalia; Díaz, Jorge; Contreras, Pamela; Campos, América; Rojas Celis, Victoria; Burgos Ravanal, Renato; Lobos González, Lorena; Torres Gómez, Vicente; Pérez, Viviana I.; Frei, Balz; Leyton Campos, Lisette; Quest, Andrew F. G. (Nature, 2020)
      Caveolin-1 (CAV1) enhanced migration, invasion, and metastasis of cancer cells is inhibited by co-expression of the glycoprotein E-cadherin. Although the two proteins form a multiprotein complex that includes beta-catenin, ...
    • The Porphyromonas gingivalis O antigen is required for inhibition of apoptosis in gingival epithelial cells ... 
      Soto, Cristopher; Bugueño Valdebenito, Isaac; Hoare Teuche, Anilei; González, S.; Vengas Díaz, Darna; Melgar Rodríguez, Samanta; Vernal Astudillo, Rolando; Gamonal Aravena, Jorge Antonio; Quest, Andrew F. G.; Pérez Donoso, José; Bravo Rodríguez, Denisse (Wiley Blackwell, 2016)
      Background and ObjectivePorphyromonas gingivalis infection induces apoptosis inhibition in gingival epithelial cells; however, it is not fully understood which bacterial effectors are involved in this process. The aim of ...
    • The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells 
      Rivas, Solange; Silva, Patricio; Reyes Rojas, Montserrat; Sepúlveda, Hugo; Solano, Luis; Acuña, Juan; Guerrero, Marisol; Varas Godoy, Manuel; Quest, Andrew F. G.; Montecino, Martín; Torres Gómez, Vicente (Nature, 2020)
      Tumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and ...
    • The urease virulence factor of Helicobacter pylori is required to induce HIF-1alpha activity in gastric cells 
      Valenzuela, M.; Cerda, P.; Bravo Rodríguez, Denisse; Quest, Andrew F. G. (Wiley, 2017)
    • Therapeutic targeting of autophagy in myocardial infarction and heart failure 
      Riquelme, Jaime A.; Chávez, Myra N.; Mondaca Ruff, David; Bustamante, Mario; Vicencio, José M.; Quest, Andrew F. G.; Lavandero González, Sergio (Taylor & Francis, 2016)
      Introduction: Myocardial infarction (MI) is the leading cause of death. When MI is not lethal, heart failure (HF) is a major consequence with high prevalence and poor prognosis. The targeting of autophagy represents a ...
    • Thy-1-mediated cell–cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4 
      Kong, Milene; Muñoz, Nicolás; Valdivia, Alejandra; Álvarez, Ávaro; Herrera Molina, Rodrigo; Cárdenas, Areli; Schneider, Pascal; Burridge, Keith; Quest, Andrew F. G.; Leyton Campos, Lisette (Elsevier, 2013)
      Cell adhesion to the extracellular matrix proteins occurs through interactions with integrins that bind to Arg-Gly-Asp (RGD) tripeptides, and syndecan-4, which recognizes the heparin-binding domain of other proteins. ...
    • Thy-1/CD90 induces metastatic breast cancer cell migration 
      Brenet, M.; Martinez, S.; Quest, Andrew F. G.; Leyton, L. (American Society Cell Biology, 2017)