Browsing by Author "201-0010582"
Now showing items 41-60 of 62
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Bollo Dragnic, Soledad; Núñez Vergara, Luis; Barrientos Vargas, Claudia Marjorie; Squella Serrano, Juan (WILEY-V C H VERLAG GMBH, 2005-09)The electrochemical behavior of iodo nitroimidazole derivatives such as 1-methyl-4-iodo-5-nitroimidazole (M-I-NIm) and 1-methyl-2,4-diiodo-5-nitroimidazole (M-I-2-NIm) and the parent compound 1-methyl-5-nitroimidazole ...
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Núñez Vergara, Luis; Squella Serrano, Juan; Olea Azar, Claudio; Bollo Dragnic, Soledad; Navarrete Encina, Patricio; Sturm Schaub, Juan (PERGAMON-ELSEVIER SCIENCE, 2000)This paper reports both the electrochemical characterization and the reactivity of the nitroso radical anion from nitrosobenzene with glutathione. The reduction of nitrosobenzene to the corresponding nitroso radical anion ...
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Oyarzún Ampuero, Felipe; Guerrero Hernández, Ariel; Hassan López, Natalia; Morales Valenzuela, Javier; Bollo Dragnic, Soledad; Corvalán Rodríguez, Alejandro; Quest, Andrew F. G.; Kogan Bocian, Marcelo (Bentham, 2015)Organic and inorganic nanoparticles show great potential for cancer diagnosis and treatment. Because gastric cancer (GC) represents the second most deadly type of neoplasia worldwide, continued research efforts by scientists ...
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Fuente Salvat, Elizabeth de la (Universidad de Chile, 2012)La polimerización y agregación del péptido Aβ1-42 son procesos poco dilucidados hasta el momento, sin embargo, están fuertemente relacionados al desarrollo de la Enfermedad de Alzheimer, trastorno ...
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Bracamonte, María V.; Yáñez Soto, Claudia; Bollo Dragnic, Soledad; Rivas, Gustavo A.; Ferreyra, Nancy F. (Elsevier, 2014)In this work, we characterize the electrochemical behavior of a new ferrocenyl-modified, hyperbranched poly(ethylenimine) (HBPei-Fc). The effects of the ionic strength, pH and the nature of the anion of the supporting ...
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Bollo Dragnic, Soledad; Núñez Vergara, Luis; Bontá, M.; Chauviere, G.; Perie, J.; Squella Serrano, Juan (WILEY-V C H VERLAG GMBH, 2001-07)Megazol (2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazol, CAS 19622-55-0), a highly active compound used against several of Trypanosoma cruzi, the causative agent of Chagas disease, is electrochemically studied ...
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Bracamonte, María V.; Bollo Dragnic, Soledad; Labbé, Pierre; Rivas, Gustavo A.; Ferreyra, Nancy F. (ELSEVIER, 2011-01-01)We report for the first time the use of quaternized chitosan (QCHI) for the immobilization of gold nanopartides (NP) and glucose oxidase (GOD), the characterization of the resulting platform and its biocatalytic activity ...
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Muñoz Becerra, Karina; Báez, Daniela; Zagal, José H.; Bollo Dragnic, Soledad; Toro Labb, Alejandro; Venegas, Ricardo; Recio, F. Javier (Pergamon-Elsevier Science, 2020)Following previous studies where the metal-centered redox potentials of MN4 complexes are proposed as a reactivity descriptor for different electrochemical reactions, in the present work we expand this idea to a series of ...
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Núñez Vergara, Luis; Bollo Dragnic, Soledad; Olea Azar, Claudio; Santander, Paola; Gunckel, Soledad; Squella Serrano, Juan (Sociedad Chilena de Química, 1998)This paper reports the scavenging of the nitro radical anion of nisoldipine by N-acetylcysteine assessed by cyclic volatammetry (CV) and EPR spectroscopic techniques. Studies by CV on the reactivity of the radical were ...
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Squella Serrano, Juan; Bollo Dragnic, Soledad; Núñez Vergara, Luis (BENTHAM SCIENCE PUBL, 2005-04)The redox chemistry of different nitro compounds of biological significance is focused to understand how the reduction of the nitro group can play an active role in several aspects as: electroanalytical determinations, ...
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Báez, Daniela F.; Pardo, Helena; Laborda, Ignacio; Marco, José F.; Yañez Soto, Claudia; Bollo Dragnic, Soledad (MDPI, 2017)For the first time a critical analysis of the influence that four different graphene oxide reduction methods have on the electrochemical properties of the resulting reduced graphene oxides (RGOs) is reported. Starting from ...
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Bollo Dragnic, Soledad; Jara Ulloa, Paola Andrea; Finger Caraccioli, Sebastián; Núñez Vergara, Luis; Squella Serrano, Juan (ELSEVIER SCIENCE SA, 2005-04-01)A scanning electrochemical microscope (SECM), in the tip generation substrate collection and feedback modes, was used in a method to characterize the electrode mechanism of the O-2/O-2*(-) couple in dimethylsulphoxide ...
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Briso Contreras, Pedro Antonio (Universidad de Chile, 2009)
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The effect of 5-substitution on the electrochemical behavior and antitubercular activity of PA-824 Bollo Dragnic, Soledad; Núñez Vergara, Luis; Kang, Sunhee; Zhang, Liang; Boshoff, Helena I.; Barry, Clifton; Squella Serrano, Juan; Dowd, Cynthia S. (PERGAMON-ELSEVIER SCIENCE LTD, 2011-01-15)Nitroimidazole PA-824 is part of an exciting new class of compounds currently undergoing clinical evaluation as novel TB therapeutics. The recently elucidated mechanism of action of PA-824 involves reduction of the ...
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Maya Arango, Juan; Bollo Dragnic, Soledad; Núñez Vergara, Luis; Squella Serrano, Juan; Repetto Scaramelli, Yolanda; Morello Casté, Antonio; Perie, J.; Chauviere, G. (PERGAMON-ELSEVIER SCIENCE, 2003-03-15)With the aim of determining the actual target(s) of nitro-group bearing compounds considered as possible leads for the development of drugs against Chagas' disease, we studied in parallel nitrofurans and nitroimidazoles. ...
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Voltammetric behavior of zaleplon and its differential pulse polarographic determination in capsules Larenas Gutiérrez, Gipsy; Bollo Dragnic, Soledad; Rodríguez, M.; Lemus Gutiérrez, Igor; Núñez Vergara, Luis; Squella Serrano, Juan; Álvarez Lueje, Alejandro (AOAC INTERNATIONAL, 2005-07)In this work both the electrochemical behavior and the analysis of the hypnotic pyrazolopyrimidine derivative zaleplon were studied. Zaleplon in ethanol-0.1 M Britton Robinson buffer solution (30-70) showed 2 irreversible, ...
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Turchán Labbé, Mariella Jéssica; Jara Ulloa, Paola Andrea; Bollo Dragnic, Soledad; Núñez Vergara, Luis; Squella Serrano, Juan; Álvarez Lueje, Alejandro (ELSEVIER SCIENCE BV, 2007-10-31)A complete electrochemical study and a novel electroanalytical procedure for brombexine quantitation are described. Bromhexine in methanol/0.1 mol L-1 Britton-Robinson buffer solution (2.5/97.5) shows an anodic response ...
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Yáñez Soto, Claudia; Bollo Dragnic, Soledad; Núñez Vergara, Luis; Squella Serrano, Juan (MARCEL DEKKER, 2001)PA-824 (2-nitro-6-(4-trifluoromethoxy-benzyloxy)-6,7-dihydro-5H-imidazo [2,1-b][1,3]oxazine) a nitroimidazopyran drug candidate for the treatment of tuberculosis was electrochemically studied with the aims of to propose a ...
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Argüello da Silva, Jacqueline; Núñez Vergara, Luis; Bollo Dragnic, Soledad; Squella Serrano, Juan (ELSEVIER SCIENCE SA, 2006-06-01)To investigate new chemotherapeutics alternatives to Chagas' disease, three 4-(5'-nitro-2'-furyl)-1,4-dihydropyridine derivatives were synthesized and electrochemically investigated in order to clarify their redox behavior. ...
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Jara Ulloa, Paola Andrea; Bollo Dragnic, Soledad; Núñez Vergara, Luis; Squella Serrano, Juan (WILEY-V C H VERLAG GMBH, 2008-06)We report the electrochemical behavior of a 4-nitroimidazole derivative, 1-methyl-4-nitro-2-hydroxymethylimidazole (4-NImMeOH), on glassy carbon electrode (GCE) modified with multiwalled carbon nanotubes (MWCNT). As ...