Browsing by Author "201-0283984"

Now showing items 1-20 of 34

    • A Multi-Serotype Approach Clarifies the Catabolite Control Protein A Regulon in the Major Human Pathogen ... 
      DebRoy, Sruti; Saldaña, Miguel; Travisany, Dante; Montano, Andrew; Galloway Peña, Jessica; Horstmann, Nicola; Yao, Hui; González Canales, Mauricio; Maass Sepúlveda, Alejandro; Latorre Mora, Mauricio; Shelburne, Samuel (Nature Publishing Group, 2016)
      Catabolite control protein A (CcpA) is a highly conserved, master regulator of carbon source utilization in gram-positive bacteria, but the CcpA regulon remains ill-defined. In this study we aimed to clarify the CcpA regulon ...
    • Administration of High Doses of Copper to Capuchin Monkeys Does Not Cause Liver Damage but Induces ... 
      Araya, Magdalena; Núñez, Héctor; Pavez, Leonardo; Arredondo Olguín, Miguel Armando; Méndez, Marco; Cisternas, Felipe; Pizarro Aguirre, Fernando; Sierralta, Walter; Uauy Dagach-Imbarack, Ricardo; González Canales, Mauricio (American Society for Nutrition, 2012)
      Liver cells respond to copper loading upregulating protective mechanisms. However, to date, except for liver content, there are no good indicators that identify individuals with excess liver copper. We hypothesized that ...
    • CCS and SOD1 mRNA are reduced after copper supplementation in peripheral mononuclear cells of individuals ... 
      Suazo Romo, Miriam; Olivares, Felipe; Méndez, Marco; Pulgar Tejo, Rodrigo; Prohaska, Joseph R.; Arredondo Olguín, Miguel Armando; Pizarro Aguirre, Fernando; Ordóñez Pizarro, Fernando; Araya, Magdalena; González Canales, Mauricio (ELSEVIER SCIENCE INC, 2008-04)
      The limits of copper homeostatic regulation in humans are not known, making it difficult to define the milder effects of early copper excess. Furthermore, a robust assay to facilitate the detection of early stages of ...
    • Cop-like operon: Structure and organization in species of the Lactobacillale order 
      Reyes, Angélica; Leiva, Andrea; Cambiazo Ayala, Liliana; Méndez, Marco; González Canales, Mauricio (2006)
      Copper is an essential and toxic trace metal for bacteria and, therefore, must be tightly regulated in the cell. Enterococcus hirae is a broadly studied model for copper homeostasis. The intracellular copper levels in ...
    • CutC is induced late during copper exposure and can modify intracellular copper content in Enterococcus faecalis 
      Latorre, Mauricio; Olivares, Felipe; Reyes Jara, Angélica; López, Guadalupe; González Canales, Mauricio (Elsevier, 2011)
      Copper is a micronutrient that is required for proper metabolic functioning of most prokaryotic and eukaryotic organisms. To sustain an adequate supply of copper, a cell requires molecular mechanisms that control the ...
    • Different Transcriptional Responses from Slow and Fast Growth Rate Strains of Listeria monocytogenes Adapted ... 
      Cordero Mattos, Ninoska; Maza, Felipe; Navea Pérez, Helen; Aravena, Andrés; Márquez Fontt, Bárbara; Navarrete Wallace, Paola; Figueroa Gronemeyer, Guillermo; González Canales, Mauricio; Latorre Mora, Mauricio; Reyes Jara, Angélica (Frontiers Media, 2016)
      Listeria monocytogenes has become one of the principal foodborne pathogens worldwide. The capacity of this bacterium to grow at low temperatures has opened an interesting field of study in terms of the identification and ...
    • Effects of postharvest treatments on gene expression in Prunus persica fruit: Normal and altered ripening 
      Pavez, Leonardo; Hödar Quiroga, Christian Eduardo; Olivares, Felipe; González Canales, Mauricio; Cambiazo Ayala, Liliana (Elsevier B.V., 2013)
      Peach (Prunus persica) fruit have a short shelf-life, and the most common method employed to delay ripening and increase their postharvest life is cold storage. However, after extended storage at low temperature some ...
    • Epidemiological, clinical and biochemical characterization of the p.(Ala359Asp) SMPD1 variant causing ... 
      Acuna, Mariana; Martinez, Pablo; Moraga, Carol; He, Xingxuan; Moraga Vergara, Mauricio; Hunter, Bessie; Nuernberg, Peter; Gutierrez, Rodrigo; González Canales, Mauricio; Schuchman, Edward; Luis Santos, Jose; Francisco Miquel, Juan; Mabe, Paulina; Zanlungo, Silvana (NATURE PUBLISHING GROUP, 2016)
      Niemann-Pick disease type B (NPDB) is a rare, inherited lysosomal storage disorder that occurs due to variants in the sphingomyelin phosphodiesterase 1 (SMPD1) gene and the resultant deficiency of acid sphingomyelinase ...
    • Estudio, Modelamiento y Desarrollo de Métodos de Control para Sistemas de Regulación Biológica Intracelular 
      Espinoza Armijo, Guillermo Octavio (Universidad de Chile, 2010)
      Esta tesis se centra en el marco de los sistemas dinámicos biológicos. Su objetivo central radica en el hecho de que a partir de un estudio matemático formal es posible inferir y responder interesantes preguntas ...
    • Expression of copper-related genes in response to copper load 
      González Canales, Mauricio; Reyes Jara, Angélica; Suazo Romo, Miriam; Jo, William J.; Vulpe, Chris (AMER SOC CLINICAL NUTRITION, 2008-09-01)
      Copper is an essential micronutrient for all biological systems. Multiple proteins require one or more atoms of copper for proper structure and function, but excess of copper is toxic. To prevent the consequences of copper ...
    • Fungal diversity analysis of grape musts from Central Valley-Chile and characterization of potential new ... 
      Mandakovic Seyler, Dinka; Pulgar Tejo, Rodrigo; Maldonado Soto, Jonathan; Mardones, Wladimir; González Canales, Mauricio; Cubillos, Francisco A.; Cambiazo Ayala, Liliana (MDPI, 2020)
      Autochthonous microorganisms are an important source of the distinctive metabolites that influence the chemical profile of wine. However, little is known about the diversity of fungal communities associated with grape ...
    • Gene expression profiling analysis of copper homeostasis in Arabidopsis thaliana 
      Pozo, Talía del; Cambiazo Ayala, Liliana; González Canales, Mauricio (ELSEVIER, 2010)
      As a result of copper essentiality for life, plants and most other organisms have developed a conserved and complex network of proteins to handling Cu in order to prevent its deficit and to avoid its potentially toxic ...
    • Gene expression profiling in wild-type and metallothionein mutant fibroblast cell lines 
      Armendáriz, Angela D.; Olivares, Felipe; Pulgar Tejo, Rodrigo; Loguinov, Alex; Cambiazo Ayala, Liliana; Vulpe, Christopher D.; González Canales, Mauricio (2006)
      The role of metallothioneins (MT) in copper homeostasis is of great interest, as it appears to be partially responsible for the regulation of intracellular copper levels during adaptation to extracellular excess of ...
    • Genome wide identification of Acidithiobacillus ferrooxidans (ATCC 23270) transcription factors and comparative ... 
      Hödar Quiroga, Christian; Moreno, Pablo; Genova, Alex di; Latorre, Mauricio; Reyes Jara, Angélica; Maass Sepúlveda, Alejandro; González Canales, Mauricio; Cambiazo Ayala, Liliana (Springer, 2012)
      Acidithiobacillus ferrooxidans is a chemolithoautotrophic acidophilic bacterium that obtains its energy from the oxidation of ferrous iron, elemental sulfur, or reduced sulfur minerals. This capability makes it of great ...
    • Genome-scale metabolic models of Microbacterium species isolated from a high altitude desert environment 
      Mandakovic, Dinka; Cintolesi, Ángela; Maldonado, Jonathan; Mendoza, Sebastián; Aite, Meziane; Gaete, Alexis; Saitua, Francisco; Allende, Miguel; Cambiazo Ayala, Liliana; Siegel, Anne; Maass Sepúlveda, Alejandro; González Canales, Mauricio; Latorre Mora, Mauricio (Nature, 2020)
      The Atacama Desert is the most arid desert on Earth, focus of important research activities related to microbial biodiversity studies. In this context, metabolic characterization of arid soil bacteria is crucial to understand ...
    • Identification of woolliness response genes in peach fruit after post-harvest treatments 
      González Agüero, Mauricio; Pávez, Leonardo; Ibáñez, Freddy; Pacheco Blanco, Igor; Campos Vargas, Reinaldo; Meisel, Lee; Orellana López, Ariel; Retamales Aranda, Julio; Silva Ascencio, Herman; González Canales, Mauricio; Cambiazo Ayala, Liliana (2008)
      Woolliness is a physiological disorder of peaches and nectarines that becomes apparent when fruit are ripened after prolonged periods of cold storage. This disorder is of commercial importance since shipping of peaches ...
    • A mathematical model for copper homeostasis in Enterococcus hirae 
      Pécou, Elisabeth; Maass Sepúlveda, Alejandro; Remenik Zisis, Daniel; Briche, Julien; González Canales, Mauricio (ELSEVIER, 2006-10)
      Copper is an essential micronutrient for life. It is required by a wide range of species, from bacteria to yeast, plants and mammals including humans. To prevent the consequences of the excess or deficit of copper, living ...
    • PCR-RFLP Detection and Genogroup Identification of Piscirickettsia salmonis in Field Samples 
      Aravena, Pamela; Pulgar Tejo, Rodrigo; Ortiz Severín, Javiera; Maza, Felipe; Gaete, Alexis; Martínez, Sebastián; Seron, Ervin; González Canales, Mauricio; Cambiazo Ayala, Liliana (MDPI, 2020)
      Piscirickettsia salmons, the causative agent of piscirickettsiosis, is genetically divided into two genomic groups, named after the reference strains as LF-89-like or EM-90-like. Phenotypic differences have been detected ...
    • Physiological copper exposure in Jurkat cells induces changes in the expression of genes encoding cholesterol ... 
      Gutiérrez García, Ricardo; Pozo, Talía del; Suazo Romo, Miriam; Cambiazo Ayala, Liliana; González Canales, Mauricio (Springer, 2013)
      Copper is an essential micronutrient that functions as an enzymatic cofactor in a wide range of cellular processes. Although adequate Cu levels are essential for normal metabolism, excess Cu can be toxic to cells. ...
    • Predicción computacional de genes de ARN no codificante pequeño en genomas bacterianos 
      Rogers Ahumada, Andrés Eduardo (Universidad de Chile, 2012)
      El objetivo de este estudio es desarrollar un método computacional capaz de predecir con alta especificidad y sensibilidad los genes pequeños de ARN no codificante en genomas bacterianos, identificando las variables ...