Browsing by Author "201-0300879"
Now showing items 1-20 of 65
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Caviedes Codelia, Raúl; Liberona Leppe, José; Hidalgo Tapia, Jorge; Tascón, Soledad; Salas, Karime; Jaimovich Pérez, Enrique (Elsevier, 1992)A cell line (RCMH) in permanent culture was established from surgically removed adult normal human skeletal muscle by exposure to conditioned media obtained from thyroid cells. Cells proliferated indefinitely but displayed ...
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Caviedes Codelia, Raúl; Jaimovich Pérez, Enrique; Cury, M.; Liberona Leppe, José; Doggenweiler, C. (1978-10)
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Paredes Díaz, Felipe Ignacio (Universidad de Chile, 2015)Herp es una proteína residente de la membrana del retículo endoplásmico que regula la degradación de proteínas a través del proteosoma. Este efecto lo ejerce principalmente regulando la formación del complejo de degradación ...
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Estrada Hormazábal, Manuel; Liberona Leppe, José; Miranda, Manuel; Jaimovich Pérez, Enrique (Amer Physiological Soc, 2000)Fast nongenomic steroid actions in several cell types seem to be mediated by second messengers such as intracellular calcium ([Ca2+](i)) and inositol 1,4,5-trisphosphate (IP3). We have shown the presence of both slow calcium ...
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Dünner Moreno, Natalia Hilda (Universidad de Chile, 2011)La insuficiencia renal crónica (IRC) induce una serie de alteraciones metabólicas en el músculo esquelético, debilidad muscular y disminución de la resistencia al ejercicio. Interleuquina-6 (IL-6) es una citoquina que se ...
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Campo, Andrea del; Contreras, Ignacio; Utreras Mendoza, Yildy; Jaimovich Pérez, Enrique (Federation Amer Soc Exp Biol, 2015)
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Henríquez Olguín, Carlos; Altamirano, Francisco; Valladares, Denisse; López, José; Allen, Paul; Jaimovich Pérez, Enrique (Elsevier, 2015)Duchenne muscular dystrophy is a fatal X-linked genetic disease, caused by mutations in the dystrophin gene, which cause functional loss of this protein. This pathology is associated with an increased production of reactive ...
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Vicencio Bustamante, José Manuel; Estrada, M.; Galvis, D.; Bravo, R.; Contreras Ferrat, Ariel Eduardo; Rotter, D.; Szabadkai, G.; Hill, Joseph A.; Rothermel, B. A.; Jaimovich Pérez, Enrique; Lavandero González, Sergio (BENTHAM SCIENCE PUBL LTD, 2011-05)Increasing evidence suggests that nongenomic effects of testosterone and anabolic androgenic steroids (AAS) operate concertedly with genomic effects. Classically, these responses have been viewed as separate and independent ...
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Casas Atala, Mariana; Buvinic Radic, Sonja; Jaimovich Pérez, Enrique (2014)Tetanic electrical stimulation releases adenosine triphosphate (ATP) from muscle fibers through pannexin-1 channels in a frequency-dependent manner; extracellular ATP activates signals that ultimately regulate gene ...
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Estrada Hormazábal, Manuel; Cárdenas Matus, Julio; Liberona Leppe, José; Carrasco, María Angélica; Mignery, Gregory A.; Allen, Paul D.; Jaimovich Pérez, Enrique (Amer Soc Biochemistry Molecular Biology, 2001)Potassium depolarization of skeletal myotubes evokes slow calcium waves that are unrelated to contraction and involve the cell nucleus (Jaimovich, E., Reyes, R., Liberona, J. L., and Powell, J. A. (2000) Am. J. Physiol. ...
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Estrada Hormazábal, Manuel; Espinosa, Alejandra; Gibson, C. J.; Uhlen, P.; Jaimovich Pérez, Enrique (SOC ENDOCRINOLOGY, 2005-02)Ca2+ oscillations are one of the most important signals within the cell. The mechanism for generation of Ca2+ oscillations is still not yet fully elucidated. We studied the role of capacitative Ca2+ entry (CCE) on intracellular ...
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Jorquera, Gonzalo; Altamirano, Francisco; Contreras Ferrat, Ariel Eduardo; Almarza, Gonzalo; Buvinic Radic, Sonja; Jacquemond, Vincent; Jaimovich Pérez, Enrique; Casas Atala, Mariana (The Company of Biologists, 2013)An important pending question in neuromuscular biology is how skeletal muscle cells decipher the stimulation pattern coming from motoneurons to define their phenotype as slow or fast twitch muscle fibers. We have previously ...
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Quezada Cornejo, Esteban; Díaz Vegas, Alexis; Jaimovich Pérez, Enrique; Casas Atala, Mariana (Frontiers Media, 2021)The slow calcium transient triggered by low-frequency electrical stimulation (ES) in adult muscle fibers and regulated by the extracellular ATP/IP3/IP3R pathway has been related to muscle plasticity. A regulation of muscular ...
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Parra Ortíz, María Valentina; Eisner, Verónica; Chiong Lay, Mario; Criollo Céspedes, Alfredo; Moraga, Francisco; García, Alejandra; Haertel, Steffen; Jaimovich Pérez, Enrique; Zorzano, Antonio; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ELSEVIER SCIENCE BV, 2008-01-15)Aims In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events (mitochondrial dynamics). This process is associated with cell death. We investigated ...
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Arias Calderón, Manuel; Almarza, Gonzalo; Díaz Vegas, Alexis; Contreras Ferrat, Ariel Eduardo; Valladares Ide, Denisse; Casas Atala, Mariana; Toledo Araya, Héctor; Jaimovich Pérez, Enrique; Buvinic Radic, Sonja (Biomed Central, 2016)Background: Electrical activity regulates the expression of skeletal muscle genes by a process known as “ excitation-transcription” (E-T) coupling. We have demonstrated that release of adenosine 5′-triphosphate (ATP) ...
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Svirin, Mikhail; Georgiev, Tihomir; Jaimovich Pérez, Enrique; Fink, Rainer H.A. (Cell Press, 2017-02-03)
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Cárdenas, César; Müller, Marioly; Jaimovich Pérez, Enrique; Pérez Bravo, Francisco; Buchuk, Diego; Quest, Andrew F. G.; Carrasco Friz, María Angélica (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2004-09-10)Membrane depolarization of skeletal muscle cells induces slow inositol trisphosphate-mediated calcium signals that regulate the activity of transcription factors such as the cAMP-response element-binding protein (CREB), ...
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Vásquez Cabrera, Vanessa del Carmen; Vega Reinoso, Carolina Elena (Universidad de Chile, 2007)
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Araya, Roberto; Liberona Leppe, José; Cárdenas Matus, Julio; Riveros Keller, Nora; Estrada Hormazábal, Manuel; Powell, Jeanne A.; Carrasco, María Angélica; Jaimovich Pérez, Enrique (Rockefeller University Press, 2003)The dihydropyridine receptor (DHPR), normally a voltage-dependent calcium channel, functions in skeletal muscle essentially as a voltage sensor, triggering intracellular calcium release for excitation-contraction coupling. ...
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Bustamante, Mario; Fernández Verdejo, Rodrigo; Jaimovich Pérez, Enrique; Buvinic Radic, Sonja (American Physiological Society, 2014)S. Electrical stimulation induces IL-6 in skeletal muscle through extracellular ATP by activating Ca2 signals and an IL-6 autocrine loop. Am J Physiol Endocrinol Metab 306: E869 –E882, 2014. First published February ...