Browsing by Author "201-0427532"
Now showing items 1-20 of 27
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(ELSEVIER, 2006-02)Alzheimer's disease(AD) is a neurodegenerative disorder characterized by the presence of extracellular amyloid deposits, consisting largely of A beta peptide and the presence of intraneuronal aggregates of neurofibillary ...
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(ELSEVIER SCIENCE INC, 2005-09)Background. The presence of brain hyperphosphorylated tau constitutes a hallmark of neurodegenerative disorders of the Alzheimer's type. This report describes the relationships between tau markers in the cerebrospinal fluid ...
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(IOS Press, 2018)Alzheimer's disease (AD) is the most frequent type of dementia in the elderly, severely affecting functional and executive skills of subjects suffering from this disease. Moreover, the distress of caregivers as well as the ...
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(COMPANY OF BIOLOGISTS LTD, 2006-10-30)A number of psychiatric and neurodegenerative disorders, such as Alzheimer’s disease, are characterized by abnormalities in the neuronal cytoskeleton. Here, we find that the enhancement in actin polymerization induced ...
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(Universidad de Chile, 2011)La Enfermedad de Alzheimer (EA) es una enfermedad neurodegenerativa, de evolución lenta y que se caracteriza por ser la forma más común de demencia. En el transcurso de la EA, la proteína tau comienza a hiperfosforilarse ...
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(Elsevier Ltd., 2009-05-19)Several cytisine derivatives have been developed in the search for more selective drugs at nicotinic acetylcholine receptors (nAChR). Binding experiments in transfected cell lines showed that the iodination of cytisine ...
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(IOS Press, 2020)Several hypotheses have been postulated to explain how Alzheimer's disease is triggered, but none of them provide a unified view of its pathogenesis. The dominant hypothesis based on build-ups of the amyloid-beta peptide ...
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(1999)The key target of this study was the tau protein kinase II system (TPK II) involving the catalytic subunit cdk5 and the regulatory component p35. TPK II is one of the tau phosphorylating systems in neuronal cells, thus ...
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(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004-04-15)Inflammation is a process that has been actively related with the onset of several neurodegenerative disorders including Alzheimer disease (AD). However, the precise implications of inflammatory response for neurodegeneration ...
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(Sociedad de Neurología, Psiquiatría y Neurocirugía, 2010-03-03)El constante aumento en la expectativa de vida en la población mundial ha incrementado la preocupación hacia la búsqueda de la comprensión de la Enfermedad de Alzheimer (EA), así como de su diagnóstico temprano y tratamiento. ...
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(2007)Microtubule-associated protein 1B (MAP1B) is the first microtubule- associated protein to be expressed during nervous system development. MAP1B belongs to a large family of proteins that contribute to the stabilization ...
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Mild cognitive impairment and Alzheimer patients display different levels of redox-active CSF iron (IOS PRESS, 2008)Oxidative stress constitutes a hallmark of Alzheimer’s disease (AD). Recent studies also point to redox active metals such as iron, copper and zinc in mediating oxidative stress in AD pathogenesis. However, the reactivity ...
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(IOS Press, 2020)Background: Alzheimer's disease (AD) is a multifactorial disease, that involves neuroinflammatory processes in which microglial cells respond to "damage signals". The latter includes oligomeric tau, iron, oxidative free ...
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(MDPI, 2018-04)Progressive neurodegenerative pathologies in aged populations are an issue of major concern worldwide. The microtubule-associated protein tau is able to self-aggregate to form abnormal supramolecular structures that include ...
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(Sociedad Chilena de Neurolología, Psiquiatría y Neurocirugía, 2010-01)El constante aumento en la expectativa de vida en la población mundial ha incrementado la preocupación hacia la búsqueda de la comprensión de la Enfermedad de Alzheimer (EA), así como de su diagnóstico temprano y tratamiento. ...
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(PERGAMON-ELSEVIER SCIENCE LTD, 2004-06-01)Oxidative stress has been demonstrated to produce modifications in several intracellular proteins that lead to alterations in their activities. Alzheimer's disease is related to an increase of oxidative stress markers, ...
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(2004)Oxidative stress has been demonstrated to produce modifications in several intracellular proteins that lead to alterations in their activities. Alzheimer's disease is related to an increase of oxidative stress markers, ...
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(IOP Publishing, 2020)Background: A major drawback in Alzheimer's disease (AD) is the lack of validated biomarkers for routine clinical diagnostic. We have reported earlier a novel blood biomarker, named Alz-tau (R), based on variants of platelet ...
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(WILEY-LISS, 2006-10)Reactive astrocytes surround amyloid depositions and degenerating neurons in Alzheimer's disease (AD). It has been previously shown that P-amyloid peptide induces inflammatory-like responses in astrocytes, leading to ...
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(IOS Press, 2010)We describe the interactions of two benzimidazole derivatives, astemizole (AST) and lansoprazole (LNS), with anomalous aggregates of tau protein (neurofibrillary tangles). Interestingly, these compounds, with important ...
