Now showing items 1-20 of 55

    • Kurte, Mónica; López, Mercedes; Aguirre, Adam; Escobar, Alejandro; Aguillón Gutiérrez, Juan Carlos; Charo, Jehad; Larsen, Christian G.; Kiessling, Rolf; Salazar Onfray, Flavio (American Association of Immunologists, 2004)
      Tumor cells treated with IL-10 were shown to have decreased, but peptide-inducible expression of MHC class I, decreased sensitivity to MHC class I-restricted CTL, and increased NK sensitivity. These findings could be ...
    • López, Mercedes N.; Pesce Reyes, Bárbara; Kurte, Mónica; Pérez Núñez, Claudio; Segal, Gabriela; Roa, Johanna; Aguillón Gutiérrez, Juan Carlos; Mendoza Naranjo, Ariadna; Gesser, Borbala; Larsen, Christian; Villablanca, Andrea; Choudhury, Aniruddha; Kiessling, Rolf; Salazar Onfray, Flavio (2011)
      We have previously demonstrated that IT9302, a nonameric peptide homologous to the C-terminal domain of human IL-10, mimics several effects of the cytokine including down-regulation of the antigen presentation machinery ...
    • Castro Santos, Patricia; Aguilera Parraguez, Jacqueline; Gutiérrez, Miguel; Aguillón Gutiérrez, Juan Carlos; Suazo, José; Contreras, Stephania; Pinochet, Carmen; Quiñones Sepúlveda, Luis; Pinochet, Carmen; Diaz Peña, Roberto (Lippicott Williams & Wilkins, 2016-04)
    • Aravena, Octavio; Pesce Reyes, Bárbara; Soto, Lilian; Orrego, Natalia; Sabugo, Francisca; Wurmann, Pamela; Molina, María Carmen; Alfaro, Jorge; Cuchacovich Turteltaub, Miguel; Aguillón Gutiérrez, Juan Carlos; Catalán Martina, Diego (2011)
      The aim of this work was to study the effect of anti-TNF treatment on CD4+ Th1, Th17 and regulatory T cells (Tregs), together with CD8+ T cells and NK cells from rheumatoid arthritis (RA) patients. For this purpose, 18 RA ...
    • Mavropoulos, John C.; Cuchacovich Turteltaub, Miguel; Llanos, Carolina; Aguillón Gutiérrez, Juan Carlos; Gatica, Hector; Pizzo, Salvatore V.; González Gronow, Mario (2005)
      Objective. To assess the enzymatic activity and biochemical status of dipeptidyl peptidase IV (DPP IV), an enzyme that participates in the degradation of proinflammatory molecules, in sera from a group of patients with ...
    • Castro Santos, P.; Verdugo Salgado, Ricardo; Alonso-Arias, R.; Gutiérrez, M. A.; Suazo Sanhueza, José; Aguillón Gutiérrez, Juan; Olloquequi, J.; Pinochet, C.; Lucía, A.; Quiñones, L. A.; Díaz Peña, R. (Nature, 2020)
      Large genome-wide association studies (GWAS) have increased our knowledge of the genetic risk factors of rheumatoid arthritis (RA). However, little is known about genetic susceptibility in populations with a large admixture ...
    • Catalán Martina, Diego; Aravena, Octavio; Sabugo, Francisca; Wurmann, Pamela; Soto, Lilian; Kalergis, Alexis M.; Cuchacovich Turteltaub, Miguel; Aguillón Gutiérrez, Juan Carlos (2010)
      Introduction: Several molecules help preserve peripheral B cell tolerance, but when altered, they may predispose to autoimmunity. This work studied the expression of the costimulatory molecule CD86 and the inhibitory ...
    • Gárate, David; Rojas Colonelli, Nicole; Peña, Corina; Salazar, Lorena; Abello Cáceres, Paula; Pesce Reyes, Bárbara; Aravena, Octavio; García González, Paulina; Ribeiro, Carolina Hager; Molina Sampayo, María Carmen; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (American College of Rheumatology, 2013)
      Objective. Dendritic cells (DCs) modulated with lipopolysaccharide (LPS) are able to reduce inflammation when therapeutically administered into mice with collagen-induced arthritis (CIA). The aim of this study was to ...
    • Gárate, David; Rojas Colonelli, Nicole; Peña, Corina; Salazar, Lorena; Abello, Paula; Pesce Reyes, Bárbara; Aravena, Octavio; García González, Paulina; Hager Ribeiro, Carolina; Molina, María C.; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (2013)
      Objective Dendritic cells (DCs) modulated with lipopolysaccharide (LPS) are able to reduce inflammation when therapeutically administered into mice with collagen-induced arthritis (CIA). The aim of this study was to uncover ...
    • Aravena Madariaga, Octavio Alexis (Universidad de ChilePrograma Cybertesis, 2006)
      Las células dendríticas (DC) son células presentadoras de antígeno (APC) profesionales que juegan un papel principal en la iniciación de la respuesta inmune primaria y secundaria. Se encuentran en distintos estados ...
    • Silva Steffens, Nora; Dutzan Muñoz, Nicolás; Hernández Ríos, Emma; Dezerega Piwonka, Andrea; Rivera Escobar, Oriana; Aguillón Gutiérrez, Juan Carlos; Aravena, Octavio; Lastres, Pedro; Pozo, Patricia; Vernal Astudillo, Rolando; Gamonal Aravena, Jorge Antonio (Blackwell, 2008)
      Background and aims: Periodontitis is an infection with an episodic nature of tissue support destruction. The aim of this work was to determine the levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal ...
    • Cuchacovich Turteltaub, Miguel; Bueno, Daniel; Carvajal Gavilán, Rodrigo; Bravo, Nicolás; Aguillón Gutiérrez, Juan Carlos; Catalán Martina, Diego; Soto Sáez, Lilian (International League of Associations for Rheumatology (ILAR), 2014)
      Tumor necrosis factor (TNF) plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA). This finding has led to the development of TNF blockers for RA treatment. However, response to these therapies is ...
    • Aguillón Gutiérrez, Juan Carlos; Cruzat, Andrea; Aravena, Octavio; Salazar, Lorena; Llanos, Carolina; Cuchacovich Turteltaub, Miguel (ELSEVIER, 2006)
      Tumour necrosis factor (TNF), a cytokine mainly produced by macrophages, is associated with a broad spectrum of biological effects, mainly associated with the host defense against microbes. The TNF gene Is located on ...
    • Peña Álvarez, Jaime Enrique (Universidad de Chile, 2011)
      La biotecnología ha adquirido un rol fundamental en la industria de producción de biofármacos, la cual ofrece nuevas alternativas para el tratamiento de diversas enfermedades. Entre los más utilizados están los anticuerpos ...
    • García González, Paulina; Schinnerling, Katina; Sepúlveda Gutierrez, Alejandro; Maggi, Jaxaira; Mehdi, Ahmed M.; Nel, Hendrik J.; Pesce Reyes, Bárbara; Larrondo Lillo, Milton; Aravena, Octavio; Molina Sampayo, María Carmen; Catalán Martina, Diego; Thomas, Ranjeny; Verdugo Salgado, Ricardo; Aguillón Gutiérrez, Juan Carlos (Frontiers Media SA, 2017)
      There is growing interest in the use of tolerogenic dendritic cells (tolDCs) as a potential target for immunotherapy. However, the molecular bases that drive the differentiation of monocyte-derived DCs (moDCs) toward a ...
    • Maggi, Jaxaira; Schinnerling, Katina; Pesce Reyes, Bárbara; Hilkens, Catharien M.; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (Frontiers Media, 2016)
      Tolerogenic dendritic cells (DCs) are a promising tool to control T cell-mediated autoimmunity. Here, we evaluate the ability of dexamethasone-modulated and monophosphoryl lipid A (MPLA)-activated DCs [MPLA-tolerogenic DCs ...
    • Maggi, Jaxaira; Schinnerling, Katina; Pesce Reyes, Bárbara; Hilkens, Catharien M.; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (Frontiers Media S.A., 2016)
      © 2016 Maggi, Schinnerling, Pesce, Hilkens, Catalán and Aguillón. Tolerogenic dendritic cells (DCs) are a promising tool to control T cell-mediated autoimmunity. Here, we evaluate the ability of dexamethasone-modulated and ...
    • García González, P. A.; Schinnerling, Katina; Sepúlveda A., Jocelyne; Ubilla Olguín, Gabriela; Soto, L.; Neira Quiroga, Oscar; Medhi, A. M.; Nel, H. J.; Catalán Martina, Diego; Thomas, R. C.; Verdugo Salgado, Ricardo; Aguillón Gutiérrez, Juan Carlos (2016)
    • Peña, Corina; Gárate, David; Contreras Levicoy, Juan; Aravena, Octavio; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (2013)
      Background. Pharmacologically modulated dendritic cells (DCs) have been shown to restore tolerance in type II collagen- (CII-) induced arthritis (CIA). We examined the effect of dexamethasone (DXM) administration as a ...
    • Pesce Reyes, Bárbara; Soto Sáez, Lilian; Sabugo Siraqyan, María Francisca; Wurmann Kiblisky, Pamela; Cuchacovich Turteltaub, Miguel; López Nitsche, Mercedes; Sotelo, P. H.; Molina Sampayo, María Carmen; Aguillón Gutiérrez, Juan Carlos; Catalán Martina, Diego (2013)
      A new paradigm has emerged relating the pathogenesis of rheumatoid arthritis (RA), focused on the balance between T helper type 17 cells and regulatory T cells (Tregs). In humans, both subpopulations depend on ...