Now showing items 1-20 of 37

    • Soto Covasich, J.; Reyes Farías, Marjorie; Torres, R. F.; Vásquez, Karla; Duarte Silva, Lissette; Quezada, J.; Jiménez Patiño, Paula; Pino, M. T.; García Nannig, Lorena; Mercado, L.; García Díaz, Diego (Elsevier, 2020)
      The establishment of a chronic inflammatory state in the adipose tissue contributes to obesity-associated insulin resistance. Hence, disrupting the inflammatory response elicited by obesity remains a relevant target to ...
    • González, Leticia; Novoa, Ulises; Moya, Jackeline; Gabrielli, Luigi; Jalil Milad, Jorge; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio; Ocaranza, María Paz (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Hypertension-induced cardiovascular and renal damage can be mediated by activation of the renin-angiotensin-aldosterone system. There are different factors beyond renin-angiotensin-aldosterone system ...
    • Ocaranza, Maria Paz; Moya, Jackeline; Barrientos, Victor; Alzamora, Rodrigo; Hevia, Daniel; Morales, Cristobal; Pinto, Melissa; Escudero, Nicolás; García Nannig, Lorena; Novoa, Ulises; Ayala, Pedro; Díaz Araya, Guillermo; Godoy, Ivan; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (Lippincott Williams and Wilkins, 2014)
      BACKGROUND:: Little is known about the biological effects of angiotensin-(1-9), but available evidence shows that angiotensin-(1-9) has beneficial effects in preventing/ameliorating cardiovascular remodeling. OBJECTIVE:: ...
    • Sotomayor Flores, Cristian; Rivera Mejías, Pablo; Vásquez Trincado, César; López Crisosto, Camila; Morales, Pablo E.; Pennanen, Christian; Polakovicova, Iva; Aliaga Tobar, Víctor; García Nannig, Lorena; Roa, Juan Carlos; Rothermel, Beverly A.; Maracaja Coutinho, Vinicius; Ho-Xuan, Hung; Meister, Gunter; Chiong, Mario; Ocaranza, María Paz; Corvalán, Alejandro H.; Parra Ortiz, Valentina; Lavandero González, Sergio (2020)
      Angiotensin-(1-9) is a peptide from the noncanonical renin-angiotensin system with anti-hypertrophic effects in cardiomyocytes via an unknown mechanism. In the present study we aimed to elucidate it, basing us initially ...
    • Jiménez, Paula; García Nannig, Lorena; Adarmes, H.; González, E.; Valenzuela, M. A. (2002)
      ATPase and ADPase activities capable of hydrolyzing nucleoside di- and triphosphates in the presence of Ca2+ are present in synovial membrane of metacarpophalangeal joint mainly associated to membrane fractions. These ...
    • Peña Oyarzún, Daniel; Bravo Sagua, Roberto; Díaz Vega, Alexis; Aleman, Larissa; Chiong Lay, Mario; García Nannig, Lorena; Bambs, Claudia; Troncoso, Rodrigo; Cifuentes, Mariana; Morselli, Eugenia; Ferreccio, Catterina; Quest, Andrew F. G.; Criollo Céspedes, Alfredo; Lavandero González, Sergio (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; ...
    • Humeres, Claudio; Vivar, Raúl; Boza Fuentes, Pía; Muñoz, Claudia; Bolivar, Samir; Anfossi, Renatto; Osorio, Jose Miguel; Olivares Silva, Francisco Javier; García Nannig, Lorena; Díaz Araya, Guillermo (Academic Press, 2016)
      © 2016 Elsevier Ltd Macrophage polarization plays an essential role in cardiac remodeling after injury, evolving from an initial accumulation of proinflammatory M1 macrophages to a greater balance of anti-inflammatory M2 ...
    • Alberti, Carolina; Gonzalez, Juan; Maldonado, Horacio; Medina, Fernando; Barriga, Andrés; García Nannig, Lorena; Kettlun, Ana; Collados, Lucía; Puente, Javier; Cartier Rovirosa, Luis; Valenzuela, Maria (2009)
      HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive CNS disease leading to corticospinal tract degeneration. Various degenerative diseases have increased neurofilament subunit concentration ...
    • Martínez Aguayo, Alejandro; Campino, Carmen; Baudrand, René; Carvajal, Cristian; Garcia, Hernán; Aglony, Marlene; Bancalari, Rodrigo; García Nannig, Lorena; Loureiro, Carolina; Vecchiola, Andrea; Tapia Castillo, Alejandra; Valdivia, Carolina; Sanhueza, Sebastián; Fuentes, Cristóbal; Lagos, Carlos F.; Solari, Sandra; Allende, Fidel; Kalergis, Alexis; Fardella, Carlos E. (Lippincott Williams & Wilkins, 2016)
      Objective: To identify novel biomarkers associated with pediatric primary hypertension. Methods: We recruited 350 participants (4-16 years). Anthropometric parameters and aldosterone, plasma renin activity, cortisol, ...
    • Ocaranza, María Paz; Riquelme Meléndez, Jaime; García Nannig, Lorena; Jalil, Jorge; Chiong Lay, Mario; Santos, Robson; Lavandero González, Sergio (Nature, 2020)
      The renin–angiotensin system is an important component of the cardiovascular system. Mounting evidence suggests that the metabolic products of angiotensin I and II — initially thought to be biologically inactive — have ...
    • Boza Fuentes, Pía; Ayala, Pedro; Vivar Sánchez, Raúl; Humeres Martínez, Claudio; Tapia Cáceres, Felipe; Muñoz, Claudia; García Nannig, Lorena; Hermoso Ramello, Marcela; Díaz Araya, Guillermo (Elsevier, 2016)
      Cardiac inflammation can be produced by pathogen-associated molecular patterns (PAMPs), from parasitic, bacterial or viral origin; or by danger-associated molecular patterns (DAMPs), released from dead cells after cardiac ...
    • Boza Fuentes, Pía; Ayala, Pedro; Vivar, Raúl; Humeres, Claudio; Cáceres, Felipe Tapia; Muñoz, Claudia; García Nannig, Lorena; Hermoso, Marcela A.; Díaz-Araya, Guillermo (Elsevier Ltd, 2016)
      © 2016 Elsevier Ltd. Cardiac inflammation can be produced by pathogen-associated molecular patterns (PAMPs), from parasitic, bacterial or viral origin; or by danger-associated molecular patterns (DAMPs), released from dead ...
    • Marambio, Paola; Toro, Barbra; Sanhueza, Carlos; Troncoso, Rodrigo; Parra, Valentina; Verdejo, Hugo; García Nannig, Lorena; Quiroga, Clara; Munafo, Daniela; Díaz Elizondo, Jessica; Bravo Sagua, Roberto; González Burgos, María Julieta; Díaz Araya, Guillermo; Pedrozo Cibils, Zully; Chiong Lay, Mario; Co (2010)
      Aggresomes are dynamic structures formed when the ubiquitin-proteasome system is overwhelmed with aggregation-prone proteins. In this process, small protein aggregates are actively transported towards the microtubule-organizing ...
    • Castro, Pablo; Gabrielli, Luigi; Verdejo, Hugo; Greig, Douglas; Mellado, Rosemarie; Concepción, Roberto; Sepulveda, Luis; Vukasovic, José Luis; García Nannig, Lorena; Pizarro, Marcela; Pivet, Deisy; Carrillo, Constanza; Tapia, Fabiola; Navarro, Mario; Troncoso, Rodrigo; Baraon (2010)
      It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the ...
    • Navarro Márquez, Mario F.; Torrealba, Natalia; Troncoso, Rodrigo; Vásquez Trincado, César Alonso; Rodríguez, Marcelo; Morales, Pablo E.; Villalobos, Elisa; Eura, Yuka; García Nannig, Lorena; Chiong Lay, Mario; Klip, Amira; Jaimovich Pérez, Enrique; Kokame, Koichi; Lavandero González, Sergio (Elsevier B.V., 2018)
      © 2018 Elsevier B.V. Skeletal muscle plays a central role in insulin-controlled glucose homeostasis. The molecular mechanisms related to insulin resistance in this tissue are incompletely understood. Herpud1 is an endoplasmic ...
    • Navarro Márquez, Mario F.; Torrealba, Natalia; Troncoso, Rodrigo; Vásquez Trincado, César; Rodríguez, Marcelo; Morales, Pablo E.; Villalobos, Elisa; Eura, Yuka; García Nannig, Lorena; Chiong Lay, Mario; Klip, Amira; Jaimovich Pérez, Enrique; Kokame, Koichi; Lavandero González, Sergio (Elsevier, 2018)
      Skeletal muscle plays a central role in insulin-controlled glucose homeostasis. The molecular mechanisms related to insulin resistance in this tissue are incompletely understood. Herpud1 is an endoplasmic reticulum membrane ...
    • García Nannig, Lorena; Verdejo, Hugo; Kuzmicic, Jovan; Zalaquett Sepúlveda, Ricardo; Gonzalez, Sergio; Lavandero González, Sergio; Corbalán, Ramón (Mosby Inc., 2012)
      Objectives: Postoperative atrial fibrillation (POAF) is a common complication after on-pump heart surgery. Several histologic abnormalities, such as interstitial fibrosis and vacuolization, have been described in atrial ...
    • Gabrielli, Luigi; Herrera, Sebastián; Contreras Briceño, Felipe; Vega, Julián; Ocaranza, María Paz; Yáñez, Fernando; Fernández, Rodrigo; Saavedra, Rodrigo; Sitges, Marta; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio; Castro, Pablo F. (Springer Verlag, 2018)
      © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Left atrial (LA) contraction is essential for left ventricular (LV) filling during exertion. We sought to evaluate the relationship of LA contraction ...
    • Campo, Andrea del; Roldán, Juan; Verdejo, Hugo E.; Zalaquett Sepúlveda, Ricardo; Becerra, Elia; Navarro Márquez, Mario; Mellado, Rosemarie; Lavandero González, Sergio; Corbalán, Ramón; García Nannig, Lorena; Chiong Lay, Mario (Elsevier, 2017)
      Background: Increased inflammation biomarkers plasma levels, including C-reactive protein (CRP), have been associated with the initiation and perpetuation of atrial fibrillation (AF). However, it is not known whether an ...
    • Stehr, Carlos B.; Mellado, Rosemarie; Ocaranza, Maria P.; Carvajal, Cristian A.; Mosso, Lorena; Becerra, Elia; Solis, Margarita; García Nannig, Lorena; Lavandero González, Sergio; Jalil Milad, Jorge; Fardella, Carlos E. (2010)
      Background: Patients with primary aldosteronism experience greater left ventricular hypertrophy and a higher frequency of cardiovascular events than do essential hypertensive patients with comparable blood pressure levels. ...