Browsing by Author "647a6824-828c-4848-b4ff-834f8718c3b5"
Now showing items 1-20 of 28
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Arancibia, Sergio; Espinoza, Cecilia; Salazar, Fabián; Del Campo, Miguel; Tampe, Ricardo; Zhong, Ta Ying; Ioannes, Pablo de; Moltedo, Bruno; Ferreira, Jorge; Lavelle, Ed C.; Manubens, Augusto; Ioannes, Alfredo de; Becker, María Inés (Public Library of Science, 2014)Hemocyanins, the huge oxygen-transporting glycoproteins of some mollusks, are used as immunomodulatory proteins with proven anti-cancer properties. The biodiversity of hemocyanins has promoted interest in identifying new ...
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Salazar, Inés; Pavani, Mario; Aranda, Waldo; Maya Arango, Juan; Morello Casté, Antonio; Ferreira, Jorge (2004)We report that oxidative phosphorylation and Ca2+ uptake processes are enhanced in liver mitochondria isolated from benzo[a]pyrene (B[a]P)-treated rats. The carcinogen did not affect either the respiratory control index ...
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Suárez Rozas, Cristian; Simpson, Sebastián; Fuentes Retamal, Sebastián; Catalán, Mabel; Ferreira, Jorge; Theoduloz, Cristina; Mella, Jaime; Cabezas, David; Cassels Niven, Bruce; Yáñez, Claudia; Castro Castillo, Vicente (Elsevier Ltd, 2019)© 2018 1,4-Naphthoquinone derivatives have been widely documented with regard to their biological properties, and particularly their anticancer activities. In the 9,10-anthraquinone family, aza-annulation involving one of ...
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Jara, José A.; Castro Castillo, Vicente; Saavedra-Olavarría, Jorge; Peredo, Liliana; Pavanni, Mario; Jaña, Fabián; Letelier, María Eugenia; Parra, Eduardo; Becker, María Inés; Morello Casté, Antonio; Kemmerling Weis, Ulrike; Maya Arango, Juan; Ferreira, Jorge (American Chemical Society, 2014)Tumor cells principally exhibit increased mitochondrial transmembrane potential (Δψm) and altered metabolic pathways. The therapeutic targeting and delivery of anticancer drugs to the mitochondria might improve treatment ...
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Parra, Eduardo; Gutiérrez, Luis; Ferreira, Jorge (Spandidos Publications, 2014)The present study examined the effect of the overexpression of early growth response gene (Egr-1) on transforming growth factor β-1 (TGF-β1) and p14ARFlevels, in PC-3 and LNCaP prostate carcinoma cell lines. Amplification ...
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Maya Arango, Juan; Orellana, Myriam; Ferreira, Jorge; Kemmerling Weis, Ulrike; López Muñoz, Rodrigo; Morello Casté, Antonio (Society of Biology of Chile, 2010)There are approximately 7.8 million people in Latin America, including Chile, who suffer from Chagas disease and another 28 million who are at risk of contracting it. Chagas is caused by the flagellate protozoan Trypanosoma ...
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Fuentes Retamal, Sebastián; Sandoval Acuña, Cristian; Peredo Silva, Liliana; Guzmán Rivera, Daniela; Pavani, Mario; Torrealba, Natalia; Truksa, Jaroslav; Castro Castillo, Vicente; Catalán Díaz, Mabel; Kemmerling Weis, Ulrike; Urra Faúndez, Félix; Ferreira, Jorge (MDPI, 2020)The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy. Previously, we described a natural compound, ...
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Ferreira, Jorge (1990)The effects of butylated hydroxyanisole (BHA), a commonly used food antioxidant, on oxygen consumption, ATPase activity, and the redox state of some electron carriers of rat liver mitochondria have been studied. It was ...
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Maya Arango, Juan; Rodríguez, Andrés; Pino, Laura; Pabón, Adriana; Ferreira, Jorge; Pavani, Mario; Repetto Scaramelli, Yolanda; Morello Casté, Antonio (Society of Biology of Chile, 2004)Proteins rich in sulfhydryl groups, such as metallothionein, are present in several strains of the parasite Trypanosoma cruzi, the etiological agent of Chagas' disease. Metallothionein-like protein concentrations ranged ...
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Ferreira, Jorge; Gil, Lionel; Stutzin Schottlander, Andrés; Orrego, Fernando (1985)Guanethidine at 5-25 mM concentrations was found to induce up to 79% inhibition of ADP-stimulated (state III) oxygen consumption in isolated rat heart, brain or liver mitochondria, when the added substrate was glutamate ...
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Ferreira, Jorge; Tapia Opazo, Gladys; Videla Cabrera, Luis (1998)The effect of gadolinium chloride (GdCl3) on the content of rat liver mitochondrial cytochromes was investigated in relation to the basal rate of O2 uptake and Kupffer cell functioning, assessed in liver perfusion studies. ...
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Campo, Miguel del; Arancibia, Sergio; Nova, Esteban; Salazar, Fabián; González, Andrea; Moltedo, Bruno; Ioannes, Pablo de; Ferreira, Jorge; Manubens, Augusto; Becker, María Inés (Sociedad Médica de Santiago, 2011-02)
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Hemocyanins as immunostimulants Hemocianinas, una herramienta inmunológica de la biomedicina actual del Campo, Miguel; Arancibia, Sergio; Nova, Esteban; Salazar, Fabián; González, Andrea; Moltedo, Bruno; Ioannes, Pablo de; Ferreira, Jorge; Manubens, Augusto; Becker, María Inés (2011)Hemocyanins, the giant oxygen transporter glycoproteins of diverse mollusks, are xenogenic to the mammalian immune system and they display a remarkable immunogenicity. Therefore they are ideal non-specific immunostimulants ...
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Becker, María Inés; Fuentes, Alejandra; Del Campo, Miguel; Manubens, Augusto; Nova, Esteban; Oliva, Harold; Faunes, Fernando; Valenzuela, María Antonieta; Campos Vallette, Marcelo; Aliaga, Alvaro E.; Ferreira, Jorge; Ioannes, Alfredo de; Ioannes, Pablo de; Moltedo, Br (2009)Hemocyanin, the oxygen transporter metallo-glycoprotein from mollusks, shows strong relationship between its notable structural features and intrinsic immunomodulatory effects. Here we investigated the individual contribution ...
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Román, Juan José Mora; Del Campo, Miguel; Villar, Javiera; Paolini, Francesca; Curzio, Gianfranca; Venuti, Aldo; Jara, Lilian; Ferreira, Jorge; Murgas, Paola; Lladser, Alvaro; Manubens, Augusto; Becker, María Inés (Hindawi Limited, 2019)Mollusk hemocyanins have been used for decades in immunological and clinical applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the treatment of superficial bladder cancer, as ...
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Parra, Eduardo; Gutiérrez, Luis; Ferreira, Jorge (2013)The p21Waf1/Cip1 protein (hereafter, p21) and the c‑Jun N-terminal kinase (JNK) are two well-characterized cell modulators that play a crucial role in cell differentiation, senescence and apoptosis. Here, we report that ...
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Parra, Eduardo; Gutiérrez, Luis; Ferreira, Jorge (Spandidos Publications, 2015)Inhibition of basal Jun kinase (JNK) activity by small interfering RNAs (siRNAs) enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells. Although the JNK pathway has been extensively studied in ...
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Parra, Eduardo; Ferreira, Jorge; Sáenz Iturriaga, Leonardo Enrique (2011)Previous studies suggest that the effects of Egr-1 on tumorigenesis are critically dependent on the levels of Egr-1 and the cellular context. For this reason, we examined the effects of blocking the Egr-1 activity by a ...
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Parra, Valentina; Verdejo, Hugo E.; Iglewski, Myriam; Del Campo, Andrea; Troncoso, Rodrigo; Jones, Deborah; Zhu, Yi; Kuzmicic Previtali, Jovan Paolo; Pennanen, Christian; López Crisosto, Camila; Jaña, Fabián; Ferreira, Jorge; Noguera, Eduard; Chiong Lay, Mario; Bernlohr, David A.; Klip, Amira (2014)Insulin regulates heart metabolism through the regulation of insulin-stimulated glucose uptake. Studies have indicated that insulin can also regulate mitochondrial function. Relevant to this idea, mitochondrial function ...
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Parra Villegas, Eduardo; Ferreira, Jorge (2010)We have examined the effect of two small interference RNA against Jnk-1 and Jnk-2 in the breast cancer cell line MCF-7. The expression of the JNK-1 and JNK-2 is frequently elevated in breast cancer and is a frequent genetic ...