Now showing items 1-20 of 41

    • Castillo Galán, Sebastián; Quezada, S.; Moraga F., Andrea; Ebensperger Darrouy, Germán; Herrera, E. A.; Beñaldo Fuentes, Felipe Augusto; Hernández, I.; Ebensperger, R.; Ramírez, S.; Llanos Mansilla, Jorge; Reyes, R. V. (American Physiological Society, 2016)
      © 2016 the American Physiological Society. Calcium signaling through store-operated channels (SOC) is involved in hypoxic pulmonary hypertension. We determined whether a treatment with 2-aminoethyldiphenylborinate (2-APB), ...
    • Castillo Galán, Sebastián; Quezada, S.; Moraga, F.; Ebensperger Darrouy, Germán; Herrera, E. A.; Beñaldo, F.; Hernández, I.; Ebensperger, R.; Ramírez, S.; Llanos Mansilla, Jorge; Reyes, R. V. (Amer Physiological Soc., 2016-10)
      Calcium signaling through store-operated channels (SOC) is involved in hypoxic pulmonary hypertension. We determined whether a treatment with 2-aminoethyldiphenylborinate (2-APB), a compound with SOC blocker activity, ...
    • Giussani, Dino A.; Riquelme González, Raquel; Sanhueza, E. M.; Hanson, M. A.; Blanco, C. E.; Llanos Mansilla, Jorge (CAMBRIDGE UNIV PRESS, 1999-02-15)
      1. The effects of ft tal intravenous treatment with phentolamine or a vasopressinergic V-1-receptor antagonist on the fetal cardiovascular responses to acute hypoxaemia in the llama were investigated. 2. Six llama fetuses ...
    • Benavides, Claudio E.; Pérez, Rubén; Cerda Espinoza, Mauricio Alexis; Cabello, Gertrudis; Riquelme, Raquel; Parer, Julian T.; Llanos Mansilla, Jorge (1989)
      Factors which allow the adaptation of adult llamas to oxygen limitation include principally: low P50, small elliptical red cells with high hemoglobin concentration, high muscle myoglobin concentration, high capillary density ...
    • Llanos Mansilla, Jorge; Serón Ferré, María; Ramachandran, Janakiraman; Creasy, Robert K.; Heymann, Michael A.; Rudolph, Abraham M. (1983)
      To determine the effects of alpha-melanocyte stimulating hormone (αMSH) on the circulation of undisturbed fetal sheep and young lambs and to explore possible mechanisms of actions, we examined the responses of ascending ...
    • Blanco, C. E.; Giussani, D. A.; Riquelme, R. A.; Hanson, M. A.; Llanos Mansilla, Jorge (1997)
      This study tested the hypothesis that in the llama fetus changes in cerebral blood flow are closely associated with changes in cerebral oxidative metabolism such as occur during transitions between electrocortical states. ...
    • Giussani, Dino A.; Riquelme, Raquel A.; Moraga, Fernando A.; McGarrigle, Hugh H.G.; Gaete, Cristián R.; Sanhueza, Emilia M.; Hanson, Mark A.; Llanos Mansilla, Jorge (1996)
      We tested the hypothesis that the llama fetus has a blunted cardiovascular chemoreflex response to hypoxemia by investigating the effects of acute hypoxemia on perfusion pressure, heart rate, and the distribution of the ...
    • Beñaldo Fuentes, Felipe; Araya Quijada, Claudio; Serón Ferre, María; Herrera Videla, Emilio; Ebensperger Darrouy, Germán; Reyes Catalán, Víctor; Llanos Mansilla, Jorge (Wiley, 2020)
    • Serón Ferré, María; Méndez, Natalia; Abarzúa Catalán, Lorena; Vilches, Nelson; Valenzuela, Francisco J.; Reynolds, Henry E.; Llanos Mansilla, Jorge; Rojas, Auristela; Valenzuela, Guillermo J.; Torres Farfán, Claudia (Elsevier, 2012)
      Throughout gestation, the close relationship between mothers and their progeny ensures adequate development and a successful transition to postnatal life. By living inside the maternal compartment, the fetus is inevitably ...
    • Serón Ferré, María; Torres Farfán, Claudia; Valenzuela, Francisco J.; Castillo Galán, Sebastián; Rojas, Auristela; Mendez, Natalia; Reynolds, Henry; Valenzuela, Guillermo; Llanos Mansilla, Jorge (Oxford University Press, 2017)
      Neonatal lambs, as with human and other neonates, have low arrhythmic endogenous levels of melatonin for several weeks until they start their own pineal rhythm of melatonin production at approximately 2 weeks of life. ...
    • Torres Farfán, Claudia; Valenzuela, Francisco J.; Mondaca, Mauricio; Valenzuela, Guillermo J.; Krause, Bernardo; Herrera Videla, Emilio; Riquelme González, Raquel; Llanos Mansilla, Jorge; Serón Ferré, María (BLACKWELL PUBLISHING, 2008-08-15)
      Although the fetal pineal gland does not secrete melatonin, the fetus is exposed to melatonin of maternal origin. In the non-human primate fetus, melatonin acts as a trophic hormone for the adrenal gland, stimulating ...
    • Llanos Mansilla, Jorge; Riquelme, Raquel A.; Herrera, Emilio A.; Ebensperger Darrouy, Germán; Krause, Bernardo; Reyes, Roberto V.; Sanhueza, Emilia M.; Pulgar, Víctor M.; Behn, Claus; Cabello, Gertrudis; Parer, Julian T.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A. (2007)
      Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the low fetal arterial PO2 of all species, but also the likely ...
    • Llanos Mansilla, Jorge; Riquelme González, Raquel; Herrera Videla, Emilio; Ebensperger Darrouy, Germán; Krause, Bernardo; Reyes, Roberto V.; Sanhueza Reinoso, Emilia; Pulgar, Víctor M.; Behn Thiele, Claus; Cabello, Gertrudis; Parer, Julian T.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A. (ELSEVIER, 2007)
      Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the lowfetal arterial PO2 of all species, but also the likely ...
    • Ebensperger Darrouy, Germán; Ebensperger, Renato; Herrera Videla, Emilio; Riquelme González, Raquel; Sanhueza Reinoso, Emilia; Lesage, Florian; Marengo, Juan José; Tejo, Rodrigo; Llanos Mansilla, Jorge; Reyes, Roberto (BLACKWELL PUBLISHING, 2005-09-15)
      In this study we looked for additional evidence to support the hypothesis that fetal llama reacts to hypoxaemia with adaptive brain hypometabolism. We determined fetal llama brain temperature, Na+ and K+ channel density ...
    • Llanos Mansilla, Jorge; Court, Denys J.; Block, Barry S.; Germain, Alfredo M.; Parer, Julian T. (1986)
      Fetal card iorespiratory changes during spontaneous prelabor uterine contractions (called contractures) were studied in 12 chronically catheterized fetal sheep at 120 to 143 days' gestation. During contractures the carcass ...
    • Behn, Claus; Araneda, Oscar F.; Llanos Mansilla, Jorge; Celedón, Gloria; González González, Gustavo Ignacio (2007)
      Hypoxia may be intensified by concurrent oxidative stress. Lack of oxygen in relation to aerobic ATP requirements, as hypoxia has been defined, goes along with an increased generation of reactive oxygen species (ROS). ...
    • Serón Ferré, María; Reynolds, H.; Mendez, N.; Mondaca, M.; Valenzuela, F. J.; Ebensperger, R.; Valenzuela, G. J.; Herrera, E. A.; Llanos Mansilla, Jorge; Torres Farfán, Claudia (Frontiers Media S.A., 2014)
      © 2014 Seron-ferre, Reynolds, Mendez, Mondaca, Ebensperger, Valenzuela, Valenzuela, Herrera, Llanos and Torres-farfan. In human and sheep newborns, brown adipose tissue (BAT) accrued during fetal development is used for ...
    • Herrera, Emilio A.; Riquelme, Raquel A.; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Ulloa, César E.; Cabello, Gertrudis; Krause, Bernardo J.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (2010)
      We determined whether postnatal pulmonary hypertension induced by 70% of pregnancy at high altitude (HA) persists once the offspring return to sea level and investigated pulmonary vascular mechanisms operating under these ...
    • Moraga, Fernando A.; Riquelme, Raquel A.; López, Aura A.; Moya, Fernando R.; Llanos Mansilla, Jorge (1994)
    • Astorga, Cristian R.; González Candia, Alejandro; Figueroa, Esteban G.; Cañas, Daniel; Ebensperger Darrouy, Germán; Reyes Catalán, Víctor; Llanos Mansilla, Jorge; Herrera Videla, Emilio; Candia, Alejandro A. (Frontiers media SA, 2018)
      Background: Chronic hypoxia and oxidative stress during gestation lead to pulmonary hypertension of the neonate (PHN), a condition characterized by abnormal pulmonary arterial reactivity and remodeling. Melatonin has strong ...