Browsing by Author "XX584907"

Now showing items 1-20 of 39

    • Adrenergic and vasopressinergic contributions to the cardiovascular response to acute hypoxaemia in the llama fetus 
      Giussani, Dino A.; Riquelme González, Raquel; Sanhueza, E. M.; Hanson, M. A.; Blanco, C. E.; Llanos Mansilla, Jorge (CAMBRIDGE UNIV PRESS, 1999-02-15)
      1. The effects of ft tal intravenous treatment with phentolamine or a vasopressinergic V-1-receptor antagonist on the fetal cardiovascular responses to acute hypoxaemia in the llama were investigated. 2. Six llama fetuses ...
    • Cardiorespiratory functions in the fetal llama 
      Benavides, Claudio E.; Pérez, Rubén; Cerda Espinoza, Mauricio Alexis; Cabello, Gertrudis; Riquelme, Raquel; Parer, Julian T.; Llanos Mansilla, Jorge (1989)
      Factors which allow the adaptation of adult llamas to oxygen limitation include principally: low P50, small elliptical red cells with high hemoglobin concentration, high muscle myoglobin concentration, high capillary density ...
    • Cardiovascular responses to alpha-melanocyte stimulating hormone during the perinatal period in sheep 
      Llanos Mansilla, Jorge; Serón Ferré, María; Ramachandran, Janakiraman; Creasy, Robert K.; Heymann, Michael A.; Rudolph, Abraham M. (1983)
      To determine the effects of alpha-melanocyte stimulating hormone (αMSH) on the circulation of undisturbed fetal sheep and young lambs and to explore possible mechanisms of actions, we examined the responses of ascending ...
    • Carotid blood flow changes with behavioral states in the late gestation llama fetus in utero 
      Blanco, C. E.; Giussani, D. A.; Riquelme, R. A.; Hanson, M. A.; Llanos Mansilla, Jorge (1997)
      This study tested the hypothesis that in the llama fetus changes in cerebral blood flow are closely associated with changes in cerebral oxidative metabolism such as occur during transitions between electrocortical states. ...
    • Chemoreflex and endocrine components of cardiovascular responses to acute hypoxemia in the llama fetus 
      Giussani, Dino A.; Riquelme, Raquel A.; Moraga, Fernando A.; McGarrigle, Hugh H.G.; Gaete, Cristián R.; Sanhueza, Emilia M.; Hanson, Mark A.; Llanos Mansilla, Jorge (1996)
      We tested the hypothesis that the llama fetus has a blunted cardiovascular chemoreflex response to hypoxemia by investigating the effects of acute hypoxemia on perfusion pressure, heart rate, and the distribution of the ...
    • Cinaciguat Reduces Prolyl Hydroxylase 2 (PHD2) protein expression in chronically hypoxic and pulmonary ... 
      Beñaldo Fuentes, Felipe; Araya Quijada, Claudio; Serón Ferre, María; Herrera Videla, Emilio; Ebensperger Darrouy, Germán; Reyes Catalán, Víctor; Llanos Mansilla, Jorge (Wiley, 2020)
    • Circadian rhythms in the fetus 
      Serón Ferré, María; Méndez, Natalia; Abarzúa Catalán, Lorena; Vilches, Nelson; Valenzuela, Francisco J.; Reynolds, Henry E.; Llanos Mansilla, Jorge; Rojas, Auristela; Valenzuela, Guillermo J.; Torres Farfán, Claudia (Elsevier, 2012)
      Throughout gestation, the close relationship between mothers and their progeny ensures adequate development and a successful transition to postnatal life. By living inside the maternal compartment, the fetus is inevitably ...
    • Deciphering the function of the blunt circadian rhythm of melatonin in the newborn lamb: impact on adrenal ... 
      Serón Ferré, María; Torres Farfán, Claudia; Valenzuela, Francisco J.; Castillo Galán, Sebastián; Rojas, Auristela; Mendez, Natalia; Reynolds, Henry; Valenzuela, Guillermo; Llanos Mansilla, Jorge (Oxford University Press, 2017)
      Neonatal lambs, as with human and other neonates, have low arrhythmic endogenous levels of melatonin for several weeks until they start their own pineal rhythm of melatonin production at approximately 2 weeks of life. ...
    • Evidence of a role for melatonin in fetal sheep physiology: direct actions of melatonin on fetal cerebral ... 
      Torres Farfán, Claudia; Valenzuela, Francisco J.; Mondaca, Mauricio; Valenzuela, Guillermo J.; Krause, Bernardo; Herrera Videla, Emilio; Riquelme González, Raquel; Llanos Mansilla, Jorge; Serón Ferré, María (BLACKWELL PUBLISHING, 2008-08-15)
      Although the fetal pineal gland does not secrete melatonin, the fetus is exposed to melatonin of maternal origin. In the non-human primate fetus, melatonin acts as a trophic hormone for the adrenal gland, stimulating ...
    • Evolving in thin air-Lessons from the llama fetus in the altiplano 
      Llanos Mansilla, Jorge; Riquelme, Raquel A.; Herrera, Emilio A.; Ebensperger Darrouy, Germán; Krause, Bernardo; Reyes, Roberto V.; Sanhueza, Emilia M.; Pulgar, Víctor M.; Behn, Claus; Cabello, Gertrudis; Parer, Julian T.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A. (2007)
      Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the low fetal arterial PO2 of all species, but also the likely ...
    • Evolving in thin air—Lessons from the llama fetus in the altiplano 
      Llanos Mansilla, Jorge; Riquelme González, Raquel; Herrera Videla, Emilio; Ebensperger Darrouy, Germán; Krause, Bernardo; Reyes, Roberto V.; Sanhueza Reinoso, Emilia; Pulgar, Víctor M.; Behn Thiele, Claus; Cabello, Gertrudis; Parer, Julian T.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A. (ELSEVIER, 2007)
      Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the lowfetal arterial PO2 of all species, but also the likely ...
    • Fetal brain hypometabolism during prolonged hypoxaemia in the llama 
      Ebensperger Darrouy, Germán; Ebensperger, Renato; Herrera Videla, Emilio; Riquelme González, Raquel; Sanhueza Reinoso, Emilia; Lesage, Florian; Marengo, Juan José; Tejo, Rodrigo; Llanos Mansilla, Jorge; Reyes, Roberto (BLACKWELL PUBLISHING, 2005-09-15)
      In this study we looked for additional evidence to support the hypothesis that fetal llama reacts to hypoxaemia with adaptive brain hypometabolism. We determined fetal llama brain temperature, Na+ and K+ channel density ...
    • Fetal cardiorespiratory changes during spontaneous prelabor uterine contractions in sheep 
      Llanos Mansilla, Jorge; Court, Denys J.; Block, Barry S.; Germain, Alfredo M.; Parer, Julian T. (1986)
      Fetal card iorespiratory changes during spontaneous prelabor uterine contractions (called contractures) were studied in 12 chronically catheterized fetal sheep at 120 to 143 days' gestation. During contractures the carcass ...
    • Hypoxia-related lipid peroxidation: Evidences, implications and approaches 
      Behn, Claus; Araneda, Oscar F.; Llanos Mansilla, Jorge; Celedón, Gloria; González González, Gustavo Ignacio (2007)
      Hypoxia may be intensified by concurrent oxidative stress. Lack of oxygen in relation to aerobic ATP requirements, as hypoxia has been defined, goes along with an increased generation of reactive oxygen species (ROS). ...
    • Impact of maternal melatonin suppression on amount and functionality of brown adipose tissue (BAT) in the ... 
      Serón Ferré, María; Reynolds, H.; Mendez, N.; Mondaca, M.; Valenzuela, F. J.; Ebensperger, R.; Valenzuela, G. J.; Herrera, E. A.; Llanos Mansilla, Jorge; Torres Farfán, Claudia (Frontiers Media S.A., 2014)
      © 2014 Seron-ferre, Reynolds, Mendez, Mondaca, Ebensperger, Valenzuela, Valenzuela, Herrera, Llanos and Torres-farfan. In human and sheep newborns, brown adipose tissue (BAT) accrued during fetal development is used for ...
    • Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension ... 
      Herrera, Emilio A.; Riquelme, Raquel A.; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Ulloa, César E.; Cabello, Gertrudis; Krause, Bernardo J.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (2010)
      We determined whether postnatal pulmonary hypertension induced by 70% of pregnancy at high altitude (HA) persists once the offspring return to sea level and investigated pulmonary vascular mechanisms operating under these ...
    • Maternal administration of glucocorticoid and thyrotropin-releasing hormone enhances fetal lung maturation ... 
      Moraga, Fernando A.; Riquelme, Raquel A.; López, Aura A.; Moya, Fernando R.; Llanos Mansilla, Jorge (1994)
    • Melatonin decreases pulmonary vascular remodeling and oxygen sensitivity in pulmonary hypertensive newborn lambs 
      Astorga, Cristian R.; González Candia, Alejandro; Figueroa, Esteban G.; Cañas, Daniel; Ebensperger Darrouy, Germán; Reyes Catalán, Víctor; Llanos Mansilla, Jorge; Herrera Videla, Emilio; Candia, Alejandro A. (Frontiers media SA, 2018)
      Background: Chronic hypoxia and oxidative stress during gestation lead to pulmonary hypertension of the neonate (PHN), a condition characterized by abnormal pulmonary arterial reactivity and remodeling. Melatonin has strong ...
    • Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs 
      Herrera Videla, Emilio; Macchiavello, Roberto; Montt, Camilo; Ebensperger Darrouy, Germán; Díaz Navarrete, Marcela; Ramírez, Santiago; Parer, Julian T.; Serrón Ferré, María; Reyes, Roberto V.; Llanos Mansilla, Jorge (John Wiley & Sons Ltd,, 2014)
      Chronic hypoxia during gestation and delivery results in oxidative stress and cerebrovascular dysfunction in the neonate. We assessed whether melatonin, a potent antioxidant and potential vasodilator, improves the cerebral ...
    • Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep 
      Torres, Flavio; González Candia, Alejandro; Montt, Camilo; Ebensperger Darrouy, Germán; Chubretovic, Magdalena; Serón Ferré, María; Reyes Catalán, Víctor; Llanos Mansilla, Jorge; Herrera Videla, Emilio (Wiley, 2015)
      Pulmonary hypertension of the newborn (PHN) constitutes a critical condition with severe cardiovascular and neurological consequences. One of its main causes is hypoxia during gestation, and thus, it is a public health ...