Now showing items 1-20 of 26

    • Figueroa, Luis; Jiménez, Carlos; Rodríguez, Jaime; Areche Medina, Carlos; Chávez, Renato; Henríquez, Marlene; Cruz, Mercedes de la; Díaz, Caridad; Segade, Yuri; Vaca Cerezo, Inmaculada (Amer Chemical Soc, 2015)
      Four new nitroasterric acid derivatives, pseudogymnoascins A-C (1-3) and 3-nitroasterric acid (4), along with the two known compounds, questin and pyriculamide, were obtained from the cultures of a Pseudogymnoascus sp. ...
    • Areche Medina, Carlos; San Martín Barrientos, Aurelio; Rovirosa, Juana; Soto Delgado, Jorge; Contreras Ramos, Renato (Elsevier, 2009-08-19)
      Meroditerpenoids, 2-[20(E)-30,70,110,150-tetramethylhexadec-2-en-10-yl]-6-methyl-1,4-benzohydroquinone diacetate and 40-chlorostypotriol triacetate, along with eight known compounds isolated from the dichloromethane ...
    • Areche Medina, Carlos (MDPI AG, 2015)
      The antioxidant features, polyphenolic composition and chromatographic fingerprints of the aerial parts from three Chilean endemic plants from the Paposo Valley located on the cost of the Atacama Desert were investigated ...
    • Calla Quispe, Erika; Robles, Juana; Areche Medina, Carlos; Sepúlveda, Beatriz (Frontiers Media, 2020)
      We report a green strategy for the extraction of lichen substances fromStereocaulon glareosum. This sustainable alternative does not use volatile toxic organic solvents, but it is assisted by microwave and is checked by ...
    • Quesada, Luisa; Areche Medina, Carlos; Astudillo, Luis; Gutiérrez, Margarita; Sepúlveda, Beatriz; San Martín Barrientos, Aurelio (Natural Products, 2012)
      Four isoflavones, isolated from the whole plant of Azorella madreporica, were identified as angustone C (1), alpinumisoflavone (2), licoisoflavone A (3) and isolupalbigenin (4) by spectroscopic studies. The compounds were ...
    • Areche Medina, Carlos; Hernández, Marco; Cano, Teresa; Ticona, Juana; Cortes, Carmen; Simirgiotis, Mario; Cáceres, Fátima; Bórquez, Jorge; Echeverría, Javier; Sepúlveda, Beatriz (Frontiers Media, 2020)
      Corryocactus brevistylus (K. Schum. ex Vaupel) Britton & Rose (Cactaceae) is a shrubby or often arborescent cactus popularly known as "sancayo" and produce an edible fruit known as "Sanky" which is consumed in Arequipa-Peru. ...
    • Areche Medina, Carlos; Vaca Cerezo, Inmaculada; Loyola, Luis Alberto; Bórquez, Jorge; Rovirosa, Juana; San Martín Barrientos, Aurelio (GEORG THIEME VERLAG KG, 2010-10)
      Two new diterpenoids, mulin-12-en-16-al-20-oic acid and 13-alpha-hydroxy-mulin-11-en-14-one-20-oic acid, were isolated from Azorella madreporica. Their structures were identified on the basis of one-dimensional and ...
    • Simirgiotis, Mario J.; Quispe, Cristina; Borquez, Jorge; Areche Medina, Carlos; Sepúlveda, Beatriz (MDPI AG, POSTFACH, CH-4005 BASEL, SWITZERLAND, 2016)
      A small Chilean variety of pears growing in the town of Toconao, an oasis located at the northeastern edge of the Salar de Atacama, northern Chile, was studied by means of modern PDA and high resolution mass spectral data ...
    • Areche Medina, Carlos; Rojas-Álvarez, Francisca; Campos-Briones, Carolina; Lima, Carlos; Pérez, Edwin G.; Sepúlveda, Beatriz (Royal Pharmaceutical Society, 2013-04-11)
      The chemical study of a dichloromethane extract from Azorella compacta was directed to the isolation of characteristic mulinane and azorellane diterpenoids in order to determine their gastroprotective activity. Methods ...
    • Parra, Teresa; Benites, Julio; Ruiz, Lina M.; Sepúlveda, Beatriz; Simirgiotis, Mario; Areche Medina, Carlos (Elsevier, 2015)
      Seventeen compounds (2-18) synthetized from the diterpenoid ent-beyer-15-en-18-ol (1) isolated from aerial part of Baccharis tola were tested for their gastroprotective activity on the model of HCl/EtOH-induced gastric ...
    • Sepulveda, Beatriz; Quispe, Cristina; Simirgiotis, Mario; Torres Benítez, Alfredo; Reyes Ortíz, Johanna; Areche Medina, Carlos (Elsevier, 2016)
      Natural or synthetic coumarins showed gastroprotective and antiulcer activity in animal models. In this study, we have synthetized twenty coumarins using classic methods to evaluate their gastroprotective effects on the ...
    • Sepúlveda, Beatriz; Quispe, Cristina; Simirgiotis, Mario; García Beltrán, Olimpo; Areche Medina, Carlos (Pergamon-Elsevier Science, 2016)
      Mulinane diterpenoids isolated from Azorella species have displayed gastroprotective effects in animal models. In this study we have transformed the main constituent, mulin-11,13-dien-20 oic acid from this plant using the ...
    • Romero, Néstor; Areche Medina, Carlos; Cubides Cárdenas, Jaime; Escobar, Natalia; García Beltrán, Olimpo; Simirgiotis, Mario J.; Céspedes, Ángel (MDPI, 2020)
      In the present work, the anthelmintic activity (AA) of ethanolic extracts obtained fromGliricidia sepium,Leucaena leucocephala, andPithecellobium dulcewas evaluated using the third-stage-larval (L-3) exsheathment inhibition ...
    • Castro, Olivio N.; Benites, Julio; Rodilla, Jesús; Santiago, Julio C.; Simirgiotis, Mario J.; Sepúlveda, Beatriz; Areche Medina, Carlos (Springer, 2017-06)
      A new depside was identified in the methanolic extract from the lichen Everniopsis trulla based on the metabolomics UHPLC-DAD-MS analysis and HESI-MS-MS fragmentation patterns along with thirty-two known compounds for the ...
    • Areche Medina, Carlos; Loyola, Luis Alberto; Bórquez, Jorge; Rovirosa, Juana; San Martín Barrientos, Aurelio (JOHN WILEY, 2008-08)
      Two new mulinane-type derivatives: 16-hydroxy mulin-11,13-dien-20-oic (2) acid and 7 alpha,16-dihydroxy mulin-11,13-dien-20-oic (3) acid were obtained by microbial transformation of mulin-11,13-dien-20-oic acid (1), along ...
    • Simoneit, Bernd R.T.; Oros, Daniel R.; Jaffé, Rudolf; Didyk-Peña, Alexandra; Areche Medina, Carlos; Sepúlveda, Beatriz; Didyk, Borys M. (MDPI AG, 2019)
      Extracts of bled resin from Azorella compacta, of the Azorelloideae family from the Andes (>4000 m), were analyzed by gas chromatography-mass spectrometry. The mass spectra of the dominant compounds of the resin and its ...
    • Simirgiotis, Mario J.; Quispe, Cristina; Areche Medina, Carlos; Sepúlveda, Beatriz (MDPI, 2016)
      Mass spectrometry has become a method of choice to characterize bioactive compounds in biological samples because of its sensitivity and selectivity. Hybrid ultra-HPLC hyphenated with Orbitrap mass analyzer is an innovative ...
    • Cornejo, Alberto; Aguilar Sandoval, Felipe; Caballero, Leonardo; Machuca, Luis; Muñoz, Patricio; Caballero, Julio; Perry, George; Ardiles, Alejandro; Areche Medina, Carlos; Melo, Francisco (Taylor & Francis, 2017)
      Alzheimer’s disease is a common tauopathy where fibril formation and aggregates are the hallmark of the disease. Efforts targeting amyloid-b plaques have succeeded to remove plaques but failed in clinical trials to improve ...
    • Areche Medina, Carlos; Benites, Julio; Cornejo, Alberto; Ruiz, Lina M.; García Beltrán, Olimpo; Simirgiotis, Mario J.; Sepúlveda, Beatriz (2015)
      Ten known meroterpenoids and the new meroterpenoid 7 were isolated from the Chilean seaweed Stypopodium flabelliforme as their acetylated derivatives. Furthermore, the known metabolite taondiol has been isolated for the ...
    • Salgado, Francisco; Albornoz, Laura; Cortez, Carmen; Stashenko, Elena; Urrea Vallejo, Kelly; Nagles, Edgar; Galicia Virviescas, Cesar; Cornejo, Alberto; Ardiles, Alejandro; Simirgiotis, Mario J.; García Beltrán, Olimpo; Areche Medina, Carlos (MDPI, 2018)
      Lichens are symbiotic associations of fungi with microalgae and/or cyanobacteria, which are considered among the slowest growing organisms, with strong tolerance to adverse environmental conditions. There are about 400 ...