Further mulinane diterpenoids from Azorella compacta

Abstract

The chemical study of a dichloromethane extract from Azorella compacta was directed to the isolation of characteristic mulinane and azorellane diterpenoids in order to determine their gastroprotective activity. Methods Usual chromatographic techniques on the extract led to the isolation of 12 compounds, which were identified by their spectroscopic properties. The HCl/ ethanol-induced gastric lesions model in mice was used to determine the gastroprotective activity.