Now showing items 1-16 of 16

    • Caviedes Codelia, Raúl; Liberona Leppe, José; Hidalgo Tapia, Jorge; Tascón, Soledad; Salas, Karime; Jaimovich Pérez, Enrique (Elsevier, 1992)
      A cell line (RCMH) in permanent culture was established from surgically removed adult normal human skeletal muscle by exposure to conditioned media obtained from thyroid cells. Cells proliferated indefinitely but displayed ...
    • Caviedes Codelia, Raúl; Jaimovich Pérez, Enrique; Cury, M.; Liberona Leppe, José; Doggenweiler, C. (1978-10)
    • Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Rapoport, Stanley I. (SOCIEDAD BIOLGIA CHILE, 2006)
      Down syndrome is determined by the presence of an extra copy of autosome 21 and is expressed by multiple abnormalities, with mental retardation being the most striking feature. The condition results in altered electrical ...
    • Arriagada Abarzúa, Christian; Bustamante, Miguel; Atwater Ransom, Illani; Rojas, Eduardo; Caviedes Codelia, Raúl; Caviedes Fernández, Pablo (ELSEVIER, 2010)
      Human Down syndrome (DS) represents the most frequent cause of mental retardation associated to a genetic condition. DS also exhibits a characteristic early onset of neuropathology indistinguishable from that observed ...
    • Allen, David D.; Caviedes Codelia, Raúl; Cárdenas, Ana María; Shimahara, Takeshi; Segura Aguilar, Juan; Caviedes Fernández, Pablo (DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2005)
      Cell culture is highly desirable, as it provides systems for ready, direct access and evaluation of tissues. The use of tissue culture is a valuable tool to study problems of clinical relevance, especially those related ...
    • Paris Pizarro, Irmgard; Dagnino Subiabre, Alexies; Marcelain Cubillos, Katherine; Bennett, L. B.; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Olea Azar, Claudio; Segura Aguilar, Juan (BLACKWELL SCIENCE LTD, 2001-04)
      The mechanism of copper (Cu) neurotoxicity was studied in the RCSN-3 neuronal dopaminergic cell line, derived from substantia nigra of an adult rat. The formation of a Cu-dopamine complex was accompanied by oxidation of ...
    • Liberona Leppe, José; Powell, Jeanne A.; Shenoi, Sheela; Petherbridge, Lee; Caviedes Codelia, Raúl; Jaimovich Pérez, Enrique (John Wiley and Sons, 1998)
      Human normal (RCMH) and Duchenne muscular dystrophy (RCDMD) cell lines, as well as newly developed normal and dystrophic murine cell lines, were used for the study of both changes in inositol 1,4,5-trisphosphate (IP3) mass ...
    • Caviedes Codelia, Raúl; Caviedes Fernández, Pablo; Liberona Leppe, José; Jaimovich Pérez, Enrique (John Wiley and Sons, 1994)
      A cell line (RCDMD), derived from a muscle biopsy taken from a 7-year-old patient with Duchenne muscular dystrophy (DMD), was established in vitro using conditioned media from the UCHT1 thyroid cell line as described ...
    • Opazo, Patricia; Saud, Katherine; Saint Pierre, Michelle de; Cárdenas, Ana María; Allen, David D.; Segura Aguilar, Juan; Caviedes Codelia, Raúl; Caviedes Fernández, Pablo (WILEY-LISS, 2006-11-01)
      We have generated immortal neuronal cell lines from normal and trisomy 16 (Ts16) mice, a model for Down syndrome (DS). Ts16 lines overexpress DS-related genes (App, amyloid precursor protein; Sod1, Cu/Zn superoxide dismutase) ...
    • Cárdenas, Ana María; Fernández Olivares, Paola; Díaz Franulic, Ignacio; González Jamett, Arlek M.; Shimahara, Takeshi; Segura Aguilar, Juan; Caviedes Codelia, Raúl; Caviedes Fernández, Pablo (Springer, 2017)
      The Na+/myo-inositol cotransporter (SMIT1) is overexpressed in human Down syndrome (DS) and in trisomy 16 fetal mice (Ts16), an animal model of the human condition. SMIT1 overexpression determines increased levels of ...
    • Saud, Katherine; Arriagada Abarzúa, Christian; Cárdenas, Ana María; Shimahara, Takeshi; Allen, David D.; Caviedes Codelia, Raúl; Caviedes Fernández, Pablo (ELSEVIER, 2006-05)
      Down syndrome (DS) in humans, or trisomy of autosome 21, represents the hyperdiploidy that most frequently survives gestation, reaching an incidence of I in 700 live births. The condition is associated with multisystemic ...
    • Hurtado Guzmán, C.; Martínez Alvarado, P.; Dagnino Subiabre, A.; Paris Pizarro, Irmgard; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Cassels Niven, Bruce; Segura Aguilar, Juan (Taylor & Francis Ltd, 2001-05-04)
      Monoamine oxidase-A (MAO-A) (amiflamine (AMF) and 4-methylthioamphetamine (MTA)) and MAO-B (Ldeprenyl) inhibitors were found to be cytotoxic in a concentration-dependent manner for RCHTcells derived from adult rat ...
    • Cabané Toledo, Patricio; Díaz Jeraldo, Juan; Rojas C., Jorge; Maluenda G., Fernando; Rencoret, Guillermo; Saud, Katherine; Godoy V., M. Loreto; Ibacache A., Daniela; Ledezma S., Alejandra; Caviedes Codelia, Raúl; Caviedes Fernández, Pablo (2007-04)
      Los cultivos de hepatocitos entregan un valioso acercamiento al estudio de las funciones metabólicas específicas del hígado, evaluación de citotoxicidad. No existen líneas humanas inmortales con función normal. La ...
    • Martínez Alvarado, P.; Dagnino Subiabre, Alexies; Paris Pizarro, Irmgard; Metodiewa, D.; Welch, C. J.; Olea Azar, Claudio; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Segura Aguilar, Juan (ACADEMIC PRESS INC, 2001-05-25)
      The endogenous dopamine-derived neurotoxin salsolinol was found to decrease survival in the dopaminergic neuronal cell line RCSN-3, derived from adult rat substantia nigra in a concentration-dependent manner (208 muM ...
    • Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Segura Aguilar, Juan (Springer Science+Business Media New York, 2013)
      Dopaminergic toxicity represents a potential mechanism underlying Parkinson’s disease (PD) neuropathology. Nevertheless, the study of such a mechanism is hampered by the lack of permanent and stable in vitro models that ...
    • Paula Lima, Andrea; Arriagada Abarzúa, Christian; Toro Sánchez, Rodrigo; Cárdenas, Ana María; Caviedes Codelia, Raúl; Ferreira, Sergio T.; Caviedes Fernández, Pablo (SOC BIOLGIA CHILE, 2008)
      We have previously characterized a number of small molecule organic compounds that prevent the aggregation of the β-amyloid peptide and its neurotoxicity in hippocampal neuronal cultures. We have now evaluated the effects ...