Now showing items 1-13 of 13

    • Segura Aguilar, Juan; Muñoz, Patricia; Paris Pizarro, Irmgard (Bentham Science, 2016)
      The pharmacological treatment of Parkinson's disease (PD) is limited to dopamine agonists and anti-cholinergic drugs that do not stop the progress of disease. L-Dopa was introduced to the treatment in 1967; this drug is ...
    • Segura Aguilar, Juan; Muñoz, Patricia; Paris Pizarro, Irmgard (Bentham Science Publishers B.V., 2016)
      © 2016 Bentham Science Publishers.The pharmacological treatment of Parkinsońs disease (PD) is limited to dopamine agonists and anti-cholinergic drugs that do not stop the progress of disease. LDopa was introduced to the ...
    • Herrera, Andrea; Muñoz Tapia, Patricia; Paris Pizarro, Irmgard; Díaz Véliz, Gabriela; Mora Gutiérrez, Sergio; Inzunza, José; Hultenby, Kjell; Cárdenas Matus, Julio; Jaña Prado, Fabián; Raisman Vozari, Rita; Gysling, Katia; Abarca, Jorge; Steinbusch, Harry; Segura Aguilar, Juan (Springer, 2016)
      L-Dopa continues to be the gold drug in Parkinson's disease ( PD) treatment from 1967. The failure to translate successful results from preclinical to clinical studies can be explained by the use of preclinical models which ...
    • Dagnino Subiabre, Alexies; Marcelain Cubillos, Katherine; Arriagada, Christian; Paris Pizarro, Irmgard; Caviedes Fernández, Pablo; Caviedes, R.; Segura Aguilar, Juan (2000)
      Angiotensin receptor II mRNA was found to be expressed in dopaminergic neuronal cell line RCSN3 of rat substantia nigra using RT-PCR reaction. Aminochrome (150 μM), a metabolite of the dopamine oxidative pathway, was found ...
    • Muñoz, Patricia; Paris Pizarro, Irmgard; Segura Aguilar, Juan (Frontiers Media, 2016-04)
    • Muñoz, Patricia; Cárdenas, Sergio; Huenchuguala, Sandro; Briceño, Andrea; Couve, Eduardo; Paris Pizarro, Irmgard; Segura Aguilar, Juan (Oxford University Press, 2015)
      It was reported that aminochrome induces the formation of alpha synuclein (SNCA) oligomers during dopamine oxidation. We found that DT-diaphorase (NQO1) prevents the formation of SNCA oligomers in the presence of ...
    • Huenchuguala, Sandro; Muñoz, Patricia; Graumann, Rebecca; Paris Pizarro, Irmgard; Segura Aguilar, Juan (Elsevier, 2016)
      Astrocytes are exposed to aminochrome via the oxidation of dopamine that is taken up from the synaptic cleft after its release from dopaminergic neurons. Glutathione transferase M2-2 (GSTM2) has been shown to protect ...
    • Urriola Cuevas, Carlos; Huenchuguala, Sandro; Muñoz, Patricia; Villa, Monica; Paris Pizarro, Irmgard; Mannervik, Bengt; Segura Aguilar, Juan (Springer New York LLC, 2015)
      © 2014, Springer Science+Business Media New York.U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 µM aminochrome increases ...
    • Costa, Silvia Lima; Silva, Victor Diogenes Amaral; dos Santos Souza, Cleide; Santos, Cleonice Creusa; Paris Pizarro, Irmgard; Muñoz, Patricia; Segura Aguilar, Juan (Springer New York LLC, 2016)
      © 2016, Springer Science+Business Media New York.Neurodegenerative disorders have a common characteristic that is the involvement of different cell types, typically the reactivity of astrocytes and microglia, characterizing ...
    • Zucca, Fabio A.; Segura Aguilar, Juan; Ferrari, Emanuele; Muñoz, Patricia; Paris Pizarro, Irmgard; Sulzer, David; Sarna, Tadeusz; Casella, Luigi; Zecca, Luigi (Elsevier, 2017)
      There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in neurons. Neuromelanin accumulates during aging and is the catecholamine-derived pigment of the dopamine neurons of the substantia ...
    • Zucca, Fabio A.; Segura Aguilar, Juan; Ferrari, Emanuele; Muñoz Tapia, Patricia; Paris Pizarro, Irmgard; Sulzer, David; Sarna, Tadeusz; Casella, Luigi; Zecca, Luigi (Elsevier, 2017-08)
      There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in neurons. Neuromelanin accumulates during aging and is the catecholamine-derived pigment of the dopamine neurons of the substantia ...
    • Segura Aguilar, Juan; Paris Pizarro, Irmgard; Muñoz, Patricia (Springer, 2016)
    • Arriagada, C.; Paris Pizarro, Irmgard; Matas, M. J. S. de las; Martínez Alvarado, P.; Cárdenas, S.; Castañeda, P.; Graumann, Rebecca; Pérez Pastene, C.; Olea Azar, Claudio; Couve, E.; Herrero, M. T.; Caviedes Fernández, Pablo; Segura Aguilar, Juan (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004-07)
      Leukoaminochrome o-semiquinone radical is generated during one-electron reduction of dopamine oxidation product aminochrome when DT-diaphorase is inhibited. Incubation of 100 muM aminochrome with 100 muM dicoumarol, an ...