Now showing items 1-20 of 27

    • Ruiz, Lina María; Jensen, Erik L.; Bustos, Rodrigo I.; Argüelloa, Graciela; Gutierrez-Garcia, Ricardo; González, Mauricio; Hernández, Claudia; Paredes, Rodolfo; Simon, Felipe; Riedel, Claudia; Ferrick, David; Elorza, Alvaro A. (Wiley-Liss Inc., 2014)
      Copper is an essential cofactor of complex IV of the electron transfer chain, and it is directly involved in the generation of mitochondrial membrane potential. Its deficiency induces the formation of ROS, large mitochondria ...
    • Moreno, Cristian; Hermosilla, Tamara; Morales, Danna; Encina, Matías; Torres-Díaz, Leandro; Díaz, Pablo; Sarmiento, Daniela; Simon, Felipe; Varela, Diego (Springer Verlag, 2015)
      © 2015, Springer-Verlag Berlin Heidelberg.In the heart, the main pathway for calcium influx is mediated by L-type calcium channels, a multi-subunit complex composed of the pore-forming subunit CaV1.2 and the auxiliary ...
    • Ramirez-Tagle, Rodrigo; Escobar, Carlos A.; Romero, Valentina; Montorfano, Ignacio; Armisén, Ricardo; Borgna, Vincenzo; Jeldes, Emanuel; Pizarro, Luis; Simon, Felipe; Echeverria, Cesar (MDPI AG, 2016)
      © 2016 by the authors; licensee MDPI, Basel, Switzerland. Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers worldwide. Chemoprevention of HCC can be achieved through the use of natural or synthetic ...
    • Sarmiento, Daniela; Montorfano, Ignacio; Cáceres, Mónica; Echeverría, César; Fernández, Ricardo; Cabello-Verrugio, Claudio; Cerda, Oscar; Tapia, Pablo; Simon, Felipe (Elsevier Ltd, 2014)
      Endothelial dysfunction is decisive and leads to the development of several inflammatory diseases. Endotoxemia-derived sepsis syndrome exhibits a broad inflammation-induced endothelial dysfunction. We reported previously ...
    • Gatica, Sebastian; Eltit, Felipe; Santibanez, Juan F.; Varela, Diego; Cabello-Verrugio, Claudio; Simon, Felipe (NLM (Medline), 2019)
      Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND: Main pathological features detected during sepsis and endotoxemia include over-secretion of pro-inflammatory ...
    • Simon, Felipe; Tapia, Pablo; Armisen, Ricardo; Echeverria, Cesar; Gatica, Sebastian; Vallejos, Alejandro; Pacheco, Alejandro; Sanhueza, Maria E.; Alvo Abodovsky, Miriam; Segovia, Erico; Torres, Rubén (Frontiers Media S.A., 2017)
      © 2017 Simon, Tapia, Armisen, Echeverria, Gatica, Vallejos, Pacheco, Sanhueza, Alvo, Segovia and Torres. Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort ...
    • Simon, Felipe; Tapia, Pablo; Armisen Yáñez, Ricardo; Echeverría, César; Gatica, Sebastian; Vallejos, Alejandro; Pacheco Durán, Alejandro; Sanhueza Villanueva, María Eugenia; Alvo Abodovsky, Miriam; Segovia, Erico; Torres, Rubén (Frontiers Media SA, 2017)
      Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD, ...
    • Simon, Felipe; Leiva Salcedo, Elías; Armisen Yáñez, Ricardo; Riveros, Ana; Cerda, Oscar; Varela, Diego; Eguiguren, Ana Luisa; Olivero, Pablo; Stutzin Schottlander, Andrés (2010)
      Necrosis is associated with an increase in plasma membrane permeability, cell swelling, and loss of membrane integrity with subsequent release of cytoplasmic constituents. Severe redox imbalance by overproduction of reactive ...
    • Simon, Felipe; Varela, Diego; Eguiguren, Ana Luisa; Díaz, Laín F.; Sala, Francisco; Stutzin Schottlander, Andrés (2004)
      In a previous work the involvement of a fenamate-sensitive Ca 2+-activated nonselective cation channel (NSCC) in free radical-induced rat liver cell necrosis was demonstrated (5). Therefore, we studied the effect of radical ...
    • Núñez-Villena, Felipe; Becerra, Alvaro; Echeverría, Cesar; Briceño, Nicolás; Porras Espinoza, Omar; Armisen Yáñez, Ricardo; Varela, Diego; Montorfano, Ignacio; Sarmiento, Daniela; Simon, Felipe (2011)
      Aims: To assess the mechanisms involved in lipopolysaccharide (LPS)-induced neuronal cell death, we examined the cellular consequences of LPS exposure in differentiated PC12 neurons and primary hippocampal neurons. Results: ...
    • Tapia, Pablo; Lillo, Felipe; Soto, Dagoberto; Escobar Oregón, Leslie Dominique; Simon, Felipe; Hernández, Karina; Alegría, Leyla; Bruhn, Alejandro (e-Century Publishing Corporation, 2016)
      A promising approach to facilitate protective mechanical ventilation is the use of extracorporeal CO2 removal techniques. Several strategies based on membrane gas exchangers have been developed. However, these techniques ...
    • Simon, Felipe; Varela, Diego; Riveros, Ana; Eguiguren, Ana Luisa; Stutzin Schottlander, Andrés (Society of Biology of Chile, 2002)
      Necrosis is considered as a non-specific form of cell death that induces tissue inflammation and is preceded by cell swelling. This increase in cell volume has been ascribed mainly to defective outward pumping of Na+ caused ...
    • Pérez, Lorena; Vallejos, Alejandro; Echeverria, Cesar; Varela, Diego; Cabello-Verrugio, Claudio; Simon, Felipe (Nature Publishing Group, 2019)
      © 2019, United States & Canadian Academy of Pathology.Systemic inflammatory diseases enhance circulating oxidative stress levels, which results in the oxidation of circulating high-density lipoprotein (oxHDL). Endothelial ...
    • Hermosilla, Tamara; Encina, Matías; Morales, Danna; Moreno, Cristian; Conejeros, Carolina; Alfaro Valdés, Hilda M.; Lagos Meza, Felipe; Simon, Felipe; Altier, Christophe; Varela, Diego (Nature Publishing Group, 2017)
      The cardiac L-type calcium channel is a multi-subunit complex that requires co-assembling of the pore-forming subunit Ca(V)1.2 with auxiliary subunits Ca-V alpha 2 delta and Ca-V beta. Its traffic has been shown to be ...
    • Aguirre, Francisco; Abrigo, Johanna; Altimiras González, Francisco; González, Andrea; Simon, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)
      Sarcopenia associated with chronic liver disease (CLD) is one of the more common extrahepatic features in patients with these pathologies. Among the cellular alterations observed in the muscle tissue under CLD is the decline ...
    • Abrigo, Johanna; Campos, Fabián; González, Francisco; Aguirre, Francisco; González, Andrea; Huerta Salgado, Camila; Conejeros, Sabrina; Simon, Felipe; Arrese, Marco; Cabrera, Daniel; Elorza, Alvaro A.; Cabello Verrugio, Claudio (MDPI, 2020)
      Sarcopenia is a condition of muscle dysfunction, commonly associated with chronic liver disease (CLD), characterized by a decline in muscle strength, the activation of the ubiquitin-proteasome system (UPS), and oxidative ...
    • González, Andrea; Orozco Aguilar, Josué; Achiardi, Óscar; Simon, Felipe; Cabello Verrugio, Claudio (MDPI, 2020)
      Severe acute respiratory syndrome coronavirus (SARS-CoV-2) has produced significant health emergencies worldwide, resulting in the declaration by the World Health Organization of the coronavirus disease 2019 (COVID-19) ...
    • Echeverría, Cesar; Montorfano, Ignacio; Cabello Verrugio, Claudio; Armisén, Ricardo; Varela, Diego; Simon, Felipe (Lippincott Williams and Wilkins, 2015)
      © 2015 Wolters Kluwer Health | Lippincott Williams & Wilkins.Objective: To study whether transient receptor potential melastatin 4 (TRPM4) participates in endothelial fibrosis and to investigate the underlying mechanism. ...
    • Echeverría, César; Romero, Valentina; Arancibia, Rodrigo; Klahn, Hugo; Montorfano, Ignacio; Armisen Yáñez, Ricardo; Borgna, Vincenzo; Simon, Felipe; Ramírez Tagle, Rodrigo (Springer, 2016)
      Trypanosoma cruzi (T. cruzi) is the parasite that causes Chagas disease. Nifurtimox is the most used drug against the T. cruzi, this drug increases intermediaries nitro group, being mainly responsible for the high toxicity ...
    • Echeverría, César; Romero, Valentina; Arancibia, Rodrigo; Klahn, Hugo; Montorfano, Ignacio; Armisen, Ricardo; Borgna, Vincenzo; Simon, Felipe; Ramirez-Tagle, Rodrigo (Springer Netherlands, 2016)
      © 2016, Springer Science+Business Media New York.Trypanosoma cruzi (T. cruzi) is the parasite that causes Chagas disease. Nifurtimox is the most used drug against the T. cruzi, this drug increases intermediaries nitro ...