Now showing items 1-20 of 23

    • Urra, Hery; Hetz Flores, Claudio (Cell Press, 2014)
      Tumors rely on the unfolded protein response (UPR) and angiogenesis to survive the metabolic stress of hypoxia. Karali et al. (2014) revealed that VEGF signaling engages UPR sensors in an unconventional manner that is ...
    • Rodriguez, Diego A.; Zamorano, Sebastian; Lisbona, Fernanda; Rojas Rivera, Diego; Urra, Hery; Cubillos-Ruiz, Juan R.; Armisen Yáñez, Ricardo; Henriquez, Daniel R.; Cheng, Emily; Letek, Michal; Vaisar, Tomas; Irrazabal, Thergiory; González Billault, Christian; Letai, Antho (2012)
      Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the unfolded protein response (UPR) stress sensor inositol-requiring enzyme 1α(IRE1α), which functions as an endoribonuclease that splices the ...
    • Díaz, María I.; Díaz, Paula; Castillo Bennett, Jimena; Urra, Hery; Ortiz, Rina; Contreras Orellana, Pamela; Hetz Flores, Claudio; Quest, Andrew F. G. (Springer Nature, 2020)
      Caveolin-1 (CAV1), is a broadly expressed, membrane-associated scaffolding protein that acts both, as a tumor suppressor and a promoter of metastasis, depending on the type of cancer and stage. CAV1 is downregulated in ...
    • Groenendyk, Jody; Paskevicius, Tautvydas; Urra, Hery; Viricel, Clement; Wang, Kui; Barakat, Khaled; Hetz Flores, Claudio; Kurgan, Lukasz; Agellon, Luis B.; Michalak, Marek (Nature Publishing Group, 2018)
      © 2018, The Author(s). Cyclosporine, a widely used immunosuppressant in organ transplantation and in treatment of various autoimmune diseases, activates the unfolded protein response (UPR), an ER stress coping response. ...
    • Lobos González, Lorena; Aguilar, Lorena; Díaz Jara, Jorge; Díaz, Natalia; Urra, Hery; Torres Gómez, Vicente; Silva, Verónica; Fitzpatrick, Christopher; Lladser, Álvaro; Hoek, Keith S.; Leyton Campos, Lisette; Quest, Andrew F. G. (2013)
      Theroleofcaveolin-1(CAV1)incancerishighlycontroversial.CAV1suppressesgenesthatfavortumordevelopment, yet also promotes focal adhesion turnover and migration of metastatic cells. How these contrasting observations relate ...
    • Limia, Celia Maria; Sauzay, Chloé; Urra, Hery; Hetz Flores, Claudio; Chevet, Eric; Avril, Tony (MDPI AG, 2019)
      Endoplasmic reticulum (ER) proteostasis is often altered in tumor cells due to intrinsic (oncogene expression, aneuploidy) and extrinsic (environmental) challenges. ER stress triggers the activation of an adaptive response ...
    • Obacz, Joanna; Avril, Tony; Le Reste, Pierre Jean; Urra, Hery; Quillien, Véronique; Hetz Flores, Claudio; Chevet, Eric (American Association for the Advancement of Science, 2017)
      © 2017 The Authors, some rights reserved.Cellular stress induced by the accumulation of misfolded proteins at the endoplasmic reticulum (ER) is a central feature of secretory cells and is observed in many tissues in various ...
    • Urra, Hery; Dufey, Estefanie; Avril, Tony; Chevet, Eric; Hetz Flores, Claudio (Cell Press, 2016)
      © 2016 Elsevier Inc. Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis, thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an adaptive mechanism ...
    • Dufey, Estefanie; Urra, Hery; Hetz Flores, Claudio (Academic Press, 2015)
      © 2015 Elsevier Ltd. Endoplasmic reticulum (ER) stress is generated by various physiological and pathological conditions that induce an accumulation of misfolded proteins in its lumen. ER stress activates the unfolded ...
    • Urra, Hery; Henríquez, Daniel R.; Cánovas, José; Villarroel Campos, David Leonardo; Carreras Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Álvarez Rojas, Sebastián; Figueroa, Ricardo; Vidal, Rene L.; Rodriguez, Diego A.; Rivera, Claudia (Nature Publishing Group, 2018)
      © 2018, The Publisher.In the version of this Article originally published, the competing interests statement was missing. The authors declare no competing interests; this statement has now been added in all online versions ...
    • Urra, Hery; Hetz Flores, Claudio (Nature Publishing Group, 2017)
      PERK is a major sensor of the unfolded protein response controlling cell fate under endoplasmic reticulum (ER) stress. A new study reveals an additional step for optimal PERK signaling, involving the binding of CNPY2 to ...
    • Urra, Hery; Hetz Flores, Claudio (Nature Publishing Group, 2017)
      PERK is a major sensor of the unfolded protein response controlling cell fate under endoplasmic reticulum (ER) stress. A new study reveals an additional step for optimal PERK signaling, involving the binding of CNPY2 to ...
    • Valenzuela, Manuel; Pérez Pérez, Guillermo; Corvalán, Alejandro H.; Carrasco, Gonzalo; Urra, Hery; Bravo, Denisse; Toledo, Héctor; Quest, Andrew F. G. (2010)
      Helicobacter pylori infects the human stomach and modifies signaling pathways that affect gastric epithelial cell proliferation and viability. Chronic exposure to this pathogen contributes to the onset of gastric atrophy, ...
    • González Quiroz, Matias; Urra, Hery; Limia, Celia María; Hetz Flores, Claudio (Elsevier, 2018-06)
      Cancer cells are exposed to adverse conditions within the tumor microenvironment that challenge cells to adapt and survive. Several of these homeostatic perturbations insults alter the normal function of the endoplasmic ...
    • Sepúlveda, Denisse; Rojas Rivera, Diego; Rodríguez, Diego; Kohler, Andrés; Urra, Hery; Carreras Sureda, Amado; Hazari, Younis; Sierralta, Jimena; Hetz Flores, Claudio (Cell Press, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a dynamic signaling network known as the unfolded protein response (UPR). IRE1a is a major UPR transducer, determining cell fate under ER stress. We ...
    • Sepulveda, Denisse; Rojas Rivera, Diego; Rodríguez, Diego A.; Groenendyk, Jody; Köhler, Andres; Lebeaupin, Cynthia; Ito, Shinya; Urra, Hery; Carreras-Sureda, Amado; Hazari, Younis; Vasseur-Cognet, Mireille; Ali, Maruf M.U.; Chevet, Eric; Campos, Gisela; Godoy, Patricio (Cell Press, 2018)
      © 2018 Elsevier Inc. Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a dynamic signaling network known as the unfolded protein response (UPR). IRE1α is a major UPR transducer, determining cell fate ...
    • Groenendyk, Jody; Peng, Zhenling; Dudek, Elzbieta; Fan, Xiao; Mizianty, Marcin J.; Dufey, Estefanie; Urra, Hery; Sepulveda, Denisse; Rojas-Rivera, Diego; Lim, Yunki; Kim, Do Han; Baretta, Kayla; Srikanth, Sonal; Gwack, Yousang; Ahnn, Joohong; Kaufman, Randal J.; Lee, Sun (American Association for the Advancement of Science, 2014)
      The disruption of the energy or nutrient balance triggers endoplasmic reticulum (ER) stress, a process that mobilizes various strategies, collectively called the unfolded protein response (UPR), which reestablish homeostasis ...
    • Urra, Hery; Henríquez, Daniel R.; Cánovas, José; Villarroel Campos, David; Carreras Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Álvarez Rojas, Sebastián; Figueroa, Ricardo; Vidal, René L.; Rodríguez, Diego A.; Rivera, Claudia A.; Court, Felipe A.; Couve Correa, Andrés; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic Maurer, Álvaro; González Billault, Christian; Hetz Flores, Claudio (Nature, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
    • Urra, Hery; Henríquez, Daniel R.; Cánovas, José; Villarroel Campos, David Leonardo; Carreras Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Álvarez Rojas, Sebastián; Figueroa, Ricardo; Vidal, Rene L.; Rodriguez, Diego A.; Rivera, Claudia (Nature Publishing Group, 2018)
      © 2018, The Author(s). Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of ...
    • Carreras-Sureda, Amado; Jaña, Fabián; Urra, Hery; Durand, Sylvere; Mortenson, David E.; Sagredo, Alfredo; Bustos, Galdo; Hazari, Younis; Ramos-Fernández, Eva; Sassano, Maria L.; Pihán, Philippe; van Vliet, Alexander R.; González-Quiroz, Matías; Torres, Angie K.; Tapia- (Nature Publishing Group, 2019)
      Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the mitochondrial matrix. Here, we report an unexpected ...