A Novel ER Stress-Independent Function of the UPR in Angiogenesis
A-Novel-ER.pdf (581.1Kb)Abstract
Tumors rely on the unfolded protein response (UPR) and angiogenesis to survive the metabolic stress of hypoxia. Karali et al. (2014) revealed that VEGF signaling engages UPR sensors in an unconventional manner that is independent of endoplasmic reticulum (ER) stress, mediated by mTOR signaling to promote endothelial cell survival and angiogenesis.
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Artículo de publicación SCOPUS
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URI: https://repositorio.uchile.cl/handle/2250/160660
DOI: 10.1016/j.molcel.2014.05.013
ISSN: 10974164
10972765
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Molecular Cell 54, May 22, 2014
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